OKAMOTO Yousuke

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Cell Physiology
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Research Interests 【 display / non-display 】

  • 不整脈

  • 特に心房細動の発生メカニズム

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Graduating School 【 display / non-display 】

  • 　
    -
    2006.03

    Akita University   Faculty of Medicine   Graduated

  • 　
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    2000.03

    Aoyama Gakuin University   Faculty of Humanities   Graduated

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Graduate School 【 display / non-display 】

  • 　
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    2012.09

    Akita University  Graduate School, Division of Medicine  Doctor's Course  Completed

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Studying abroad experiences 【 display / non-display 】

  • 2012.11
    -
    2015.03

    National Institute of Health   Visiting fellow (postdoc)

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Campus Career 【 display / non-display 】

  • 2020.06
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Lecturer  

  • 2017.11
    -
    2020.05

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Assistant Professor  

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Research Areas 【 display / non-display 】

  • Life Science / Clinical pharmacy

  • Life Science / Physiology

  • Life Science / Pharmacology

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Qualification acquired 【 display / non-display 】

  • Doctor

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Thesis for a degree 【 display / non-display 】

  • Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes.

    Okamoto Y, Takano M, Ohba T, Ono K. 

    Journal of Molecular Cellular Cardiology  52   988 - 997   2012.09  [Refereed]

    Domestic Co-author

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Research Achievements 【 display / non-display 】

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Books 【 display / non-display 】

  • Molecular Pathogenesis of Cardiac Arrhythmia

    Okamoto Y, Ono K.

    MDPI  2022.11 ISBN: 978-3-0365-5614-7

    PubMed

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2022.04  -  2025.03 

  • Grant-in-Aid for Early-Career Scientists

    Project Year： 2020.04  -  2023.03 

  • Grant-in-Aid for Young Scientists(B)

    Project Year： 2017.04  -  2020.03 

  • Cloning of the Cl- channel unique to pulmonary vein cardiomyocytes in rat

    Grant-in-Aid for Research Activity start-up

    Project Year： 2015.08  -  2017.03  Investigator(s): Yosuke Okamoto

  • Grant-in-Aid for Young Scientists (Start-up)

    Project Year： 2015.04  -  2017.03 

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Presentations 【 display / non-display 】

  • Comparative Study of Transcriptome in the Hearts Isolated from Mice, Rats, and Humans

    Okamoto Yosuke, Okada Daigo, Kobayashi Daiki, Ono Kyoichi, Ishii Kuniaki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society  2022  -  2022  Japanese Pharmacological Society

    <p>The heart is a critical organ for maintaining life in mammals and has long been one of the most important targets of scientific research, and the basic molecular mechanisms of heart beat appear to have already been established. However, few studies have focused on species differences, and challenges remain in studying genes that have universal functions across species and genes that determine species differences. Here, we analyzed transcriptome data from mouse, rat, and human atria, ventricles, and sinus node (SA) and calculated and compared specificity measure (SPM) values that account for species differences among the three cardiac regions. SA has the largest species differences and we searched for a gene, which by our criteria was SHOX2; the SPM value for SHOX2 was prominently high across species. Similarly, SPM values identified 3 atrial-specific markers, 11 ventricular-specific markers, and 17 SA-specific markers. Ontology analysis identified 70 cardiac region- and species-specific ontologies. These results suggest that reanalysis of existing data by calculating SPM values may identify novel tissue-specific and species-dependent gene expression. This study demonstrates that SHOX2 is an SA-specific transcription factor, a novel cardiac region marker, and that species-dependent ontology is important. No COI.</p>

    DOI

  • シンポジウム：不整脈発症のメカニズムに迫る - 基礎と臨床の立場から -

    岡本　洋介，永澤　悦伸，ナイン　イエイ　アウン，姫野　友紀子，野間　昭典，天野　晃，高木　大地，石井　邦明，尾野　恭一

    第97回　日本生理学会大会  2020.03  -  2020.03 

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Academic Activity 【 display / non-display 】

  • 2018.03
    -
    Now

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