研究等業績 - その他 - 山田 武千代
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18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma
Suzuki S.
Journal of Otolaryngology - Head and Neck Surgery ( Journal of Otolaryngology - Head and Neck Surgery ) 51 ( 1 ) 2022年12月
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Galectin-10 as a Potential Biomarker for Eosinophilic Diseases
Tomizawa H.
Biomolecules ( Biomolecules ) 12 ( 10 ) 2022年10月
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Quantification of Aspergillus fumigatus antigen Asp f 1 in airway tissue and allergic inflammation
Miyabe Y.
Allergy: European Journal of Allergy and Clinical Immunology ( Allergy: European Journal of Allergy and Clinical Immunology ) 77 ( 10 ) 3154 - 3156 2022年10月
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山田 武千代, 椎名 和弘, 高橋 辰, 中澤 操
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 一般社団法人 日本聴覚医学会 ) 65 ( 5 ) 347 - 347 2022年09月
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Kawasaki Y.
Pathology and Oncology Research ( Pathology and Oncology Research ) 28 2022年08月
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Suzuki S.
PLoS ONE ( PLoS ONE ) 17 ( 1 January ) 2022年01月
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Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis
Imoto Y.
Frontiers in Pharmacology ( Frontiers in Pharmacology ) 12 2022年01月
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Allergic fungal diseases in the upper and lower airways
Ueki S.
ERS Monograph ( ERS Monograph ) 2022 119 - 140 2022年
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Suzuki S.
Cancer Management and Research ( Cancer Management and Research ) 14 3293 - 3302 2022年
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Executive summary: Japanese guidelines for allergic rhinitis 2020
Okano M.
Allergology International ( Allergology International ) 2022年
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A case of Bow hunter’s syndrome due to cervical rotation and vertebral artery dissection
Koizumi K.
Equilibrium Research ( Equilibrium Research ) 81 ( 4 ) 199 - 205 2022年
<p> Bow hunter's syndrome is a form of vertebrobasilar insufficiency in which cervical rotation causes mechanical occlusion or stenosis of the vertebrobasilar artery, resulting in various symptoms, including dizziness, vertigo, and/or syncope. We report a case of Bow hunter's syndrome in which cervical rotation caused dizziness and nystagmus.</p><p> A 45-year-old woman presented to our hospital complaining of experiencing vertigo and nausea when twisting her neck. Nystagmus testing using Frenzel goggles revealed nystagmus during right cervical rotation. There was no hearing loss. Magnetic resonance imaging (MRI) showed no evidence of cerebral infarction; however, basi-parallel anatomical scanning MRI revealed arterial dissection in the left vertebral artery more peripherally than beyond the branching off of the posterior inferior cerebellar artery. Cervical ultrasonography and vertebral angiography confirmed that the patient experienced vertigo due to lack of blood flow in the proximal portion of the left vertebral artery when she rotated her neck 90 degrees to the right.</p><p> Neurosurgeons at our institution performed neurosurgical C1-C2 posterior fixation, which led to complete resolution of her symptoms.</p><p> The pathogenesis of Bow hunter's syndrome can take many distinct patterns, and the direction of cervical rotation does not always correspond to the side of the symptoms. To diagnose Bow hunter's syndrome, it is important to positively identify the onset of symptoms during cervical rotation and perform appropriate imaging studies.</p>
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Sato T.
Practica Oto-Rhino-Laryngologica ( Practica Oto-Rhino-Laryngologica ) 15 ( 9 ) 765 - 769 2022年
<p>The incidence of allergic rhinitis caused by Japanese cedar pollen has been increasing in recent years. Treatment of seasonal allergic rhinitis includes oral treatment centered on second-generation antihistamines, topical steroid sprays, sublingual immunotherapy, etc. In addition, omalizumab, an anti-IgE antibody preparation, was approved in December 2019 for use in patients with severe or very severe symptoms who show inadequate response to existing treatments. During the 2020 cedar pollinosis season, which was the first cedar pollen season in Japan after the approval of omalizumab, we treated some patients with cedar pollen-induced seasonal allergic rhinitis with omalizumab at our hospitals. We report the clinical effects of the drug administered during the pollen season in 2020 and the effects of re-administration of the drug again in 2021 in patients with Japanese cedar pollinosis.</p><p>In 2020, omalizumab was administered to 4 patients with severe symptoms and 1 patient with very severe symptoms. One of the patients received the drug for 2 weeks, while the remaining four patients received the drug for 4 weeks. All the patients showed improvement of symptoms after treatment, as compared to the symptom severity before the start of treatment. Of the 5 patients, 4 requested omalizumab treatment again in 2021, so that 80% were re-administered the drug in 2021. These patients received omalizumab statically significant earlier in 2021 as compared to 2020 (<i>p</i> = 0.014: Mann-Whitney U test). Only one of the patients also received sublingual immunotherapy. Even patients receiving sublingual immunotherapy could show severe allergic symptoms during the cedar pollinosis season, and omalizumab was effective even in the patient who showed symptoms while receiving sublingual immunotherapy at our hospital. Even when omalizumab treatment was started from the middle of the Japanese cedar pollen season, the intranasal findings improved after 2 weeks. Assessment of two patients with intranasal findings by the Japanese Rhinoconjunctivitis Quality of Life Questionnaire confirmed improvement of the nasal symptoms in patients who were treated with omalizumab. Omalizumab appears to be a useful drug for seasonal allergic rhinitis, but further studies are needed to confirm the findings.</p>
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Suzuki H.
Asian Pacific Journal of Cancer Prevention ( Asian Pacific Journal of Cancer Prevention ) 23 ( 4 ) 1271 - 1278 2022年
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鼻茸組織内アスペルギルス抗原の同定とアレルギー・好酸球性炎症
宮部 結, 山田 武千代
日本鼻科学会会誌 ( 日本鼻科学会 ) 61 ( 1 ) 240 - 241 2022年
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Investigation of Cry J1 and Cry J2 Concentrations in Japanese Cedar Pollen and Non-Pollen Seasons
Tomizawa H.
Iranian Journal of Public Health ( Iranian Journal of Public Health ) 51 ( 3 ) 705 - 707 2022年
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Suzuki S.
Medicina (Lithuania) ( Medicina (Lithuania) ) 57 ( 11 ) 2021年11月
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Cavity problem に対する浅側頭動脈筋膜弁を用いた軟組織再建術と聴力改善の意義
山田 武千代, 椎名 和弘, 高橋 辰, 中澤 操
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 一般社団法人 日本聴覚医学会 ) 64 ( 5 ) 437 - 437 2021年09月
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Eosinophil ETosis–Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis
Fukuchi M.
Arthritis and Rheumatology ( Arthritis and Rheumatology ) 73 ( 9 ) 1683 - 1693 2021年09月
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Imoto Y.
Allergology International ( Allergology International ) 70 ( 3 ) 373 - 375 2021年07月
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Trained innate lymphoid cells in allergic diseases
Ebihara T.
Allergology International ( Allergology International ) 70 ( 2 ) 174 - 180 2021年04月
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How to detect eosinophil ETosis (EETosis) and extracellular traps
Fukuchi M.
Allergology International ( Allergology International ) 70 ( 1 ) 19 - 29 2021年01月
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Suzuki S.
Advances in Clinical and Experimental Medicine ( Advances in Clinical and Experimental Medicine ) 30 ( 1 ) 41 - 48 2021年
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Sato T.
Acta Oto-Laryngologica ( Acta Oto-Laryngologica ) 141 ( 11 ) 1027 - 1032 2021年
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SDF-1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx
Toyoma S.
Oncology Letters ( Oncology Letters ) 20 ( 2 ) 1817 - 1823 2020年08月
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Suzuki S.
Auris Nasus Larynx ( Auris Nasus Larynx ) 47 ( 3 ) 485 - 488 2020年06月
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Epidemiological survey of allergic rhinitis in Japan 2019
Matsubara A.
Journal of Otolaryngology of Japan ( Journal of Otolaryngology of Japan ) 123 ( 6 ) 485 - 490 2020年06月
<p> 近年になり, スギ花粉症などのアレルギー性鼻炎の増加が指摘されている. 馬場らが中心となって1998年と2008年に全国の耳鼻咽喉科医師ならびにその家族を対象としたアンケートによる鼻アレルギー疫学調査が行われ, 有病率の推移が詳細に報告されている. 今回われわれは,前回の調査から11年後の2019年に同様の調査を行い, スギ花粉症, 通年性アレルギー性鼻炎ならびにスギ以外の花粉症の有病率を同定した. アレルギー性鼻炎全体の有病率は49.2%, スギ花粉症単独の有病率は38.8%と前回調査に比べ大きく増加していた. さらに10歳代でスギ花粉症が著明に増加していることも明らかとなった.</p>
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山田 武千代
Pharma Medica ( メディカルレビュー社 ) 38 ( 4 ) 51 - 55 2020年04月
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Outcomes of regional-based newborn hearing screening for 35,461 newborns for 5 years in Akita, Japan
Sato T.
International Journal of Pediatric Otorhinolaryngology ( International Journal of Pediatric Otorhinolaryngology ) 131 2020年04月
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山田 武千代, 椎名 和弘, 高橋 辰, 中澤 操, 佐藤 輝幸
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 一般社団法人 日本聴覚医学会 ) 63 ( 5 ) 2020年
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The investigation of salvage endoscopic laryngopharyngeal surgery after chemoradiotherapy
Kawasaki Y.
Wideochirurgia I Inne Techniki Maloinwazyjne ( Wideochirurgia I Inne Techniki Maloinwazyjne ) 15 ( 3 ) 511 - 518 2020年
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専門医を悩ませる高齢疾患への対応:―秋田県における老人性鼻漏のアンケート調査―
山田 武千代
日本耳鼻咽喉科学会会報 ( 一般社団法人 日本耳鼻咽喉科学会 ) 123 ( 6 ) 523 - 525 2020年
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鈴木 真輔, 登米 慧, 川嵜 洋平, 小泉 洸, 山田 武千代
喉頭 ( 日本喉頭科学会 ) 32 ( 2 ) 172 - 177 2020年
<p>Tracheoesophageal shunt utterance using a voice prosthesis as a substitute voice after laryngectomy is an excellent method and is widely used. However, in addition to temporary removal due to complications, the use of voice prostheses is occasionally discontinued for various reasons that lead to their permanent removal. We evaluated the voice acquisition rate, complications, and outcomes of 23 patients who underwent voice reconstruction using a voice prosthesis after total laryngectomy in our department from January 2007 to December 2018. The voice acquisition rate was 87%. Seven complications occurred in six cases, the most common of which was granulation, followed by leakage and infection in one case each, although all were eventually rescued. However, there were five cases where permanent voice prosthesis removal was necessary for reasons other than complications. Three of these patients had good voice acquisition but were unable to use the voice prosthesis due to the effects of other diseases. In the other two cases, a voice could not be obtained, and the patients expressed their desire to have the prosthesis removed. In the future, aging of voice prosthesis users and long-term use are expected, which will make it necessary not only to accurately determine the adaptation in consideration of the patient's intention, activity and living environment but also to consider how to proceed when voice prosthesis use becomes difficult due to other diseases.</p>
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アレルギーと自然免疫.
山田 武千代
Journal Otorhinolaryngology Head and Neck Surgery 36 289 - 293 2020年
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Comparison of CD16-negative selection vs. MACSxpress system for isolation of blood eosinophils
Fukuchi M.
Allergology International ( Allergology International ) 68 S11 - S13 2019年09月
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秋田大学における口腔癌 (舌以外) の治療成績
登米 慧, 宮部 結, 椎名 和弘, 飯川 延子, 齋藤 秀和, 小泉 洸, 川嵜 洋平, 鈴木 真輔, 山田 武千代
耳鼻咽喉科展望 ( 耳鼻咽喉科展望会 ) 62 ( Supplement1 ) s44 - s45 2019年06月
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秋田大学における下咽頭癌の治療成績
椎名 和弘, 宮部 結, 登米 慧, 齋藤 秀和, 辻 正博, 小泉 洸, 川嵜 洋平, 佐藤 輝幸, 鈴木 真輔, 山崎 一春, 本田 耕平, 山田 武千代
耳鼻咽喉科展望 ( 耳鼻咽喉科展望会 ) 62 ( Supplement1 ) s18 - s19 2019年06月
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登米 慧, 宮部 結, 椎名 和弘, 飯川 延子, 齋藤 秀和, 小泉 洸, 川嵜 洋平, 鈴木 真輔, 山田 武千代
耳鼻咽喉科展望 ( 耳鼻咽喉科展望会 ) 62 ( 1 ) s44 - s45 2019年
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椎名 和弘, 山崎 一春, 本田 耕平, 山田 武千代, 宮部 結, 登米 慧, 齋藤 秀和, 辻 正博, 小泉 洸, 川嵜 洋平, 佐藤 輝幸, 鈴木 真輔
耳鼻咽喉科展望 ( 耳鼻咽喉科展望会 ) 62 ( 1 ) s18 - s19 2019年
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新生児聴覚スクリーニングをパス後に発見された難聴児48例の検討:―秋田県16年間の経験から―
水野 知美, 中澤 操, 佐藤 輝幸, 高橋 辰, 山田 武千代
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 一般社団法人 日本聴覚医学会 ) 62 ( 1 ) 52 - 58 2019年
<p>要旨: 秋田県で新生児聴覚スクリーニング (Newborn hearing screening: 以下 NHS と略) が開始されてから17年が経過し, 2012年からは受検率が94%を超えている。 NHS システムを構築する中で, NHS 後も聴こえに関心を持ち続けるための啓発や, 関係機関との連携ができ, NHS 後に難聴児が発見された場合の対応も確立されたと考えられる。 今回の調査で, 聴力型により NHS では発見できない難聴児がいること。 遅発性や進行性の難聴児がかなりの数存在することが示唆され, NHS パス後も引き続き聴覚に気を配り, 関係機関との連携を強化していく必要性が示唆された。 今回画像診断が不完全な症例が含まれたことや, 今後遺伝子診断をする例の増加が予測されること, 先天性サイトメガロウィルス感染症のフォローアップ例が増えている事などから, 今後は遅発性及び進行性難聴の原因について明確にしていく必要性があると考えた。</p>
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Surgery for facial nerve schwanoma
Yamada T.
Oto-Rhino-Laryngology Tokyo ( Oto-Rhino-Laryngology Tokyo ) 61 ( 2 ) 78 - 84 2019年
<p> Since the management of facial nerve schwannoma (FNS) is extremely rare intratemporal FNS has the potential to be misdiagnosed as Bell's palsy or intraparotid FNS might be often misdiagnosed as pleomorphic adenoma or another parotid tumor which might lead to a delay in diagnosis. In this manuscript, we have reviewed the literature regarding the management of IFNS and reported the authors' experiences in the treatment of IFNS. In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. The correct diagnosis for extratemporal FNS depends mainly on intraoperative observation of the gross relation between the tumor and the FN or excision frozen biopsy examination. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. The integrity of the FN should be preserved for patients with IFNS using tripping method whenever possible. In cases where the facial nerve has been interrupted during surgery, the cable nerve interpositioning technique is a convenient and well-accepted procedure for immediate restitution of the nerve. In order to obtain a better facial outcome, facial nerve is reconstructed also along with facial-hypoglossal nerve anastomosis at the same time. The physical rehabilitation is very important to decrease facial contracture and synkinesis.</p>
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山田 武千代, 椎名 和弘, 佐藤 輝幸, 高橋 辰, 中澤 操, 水野 知美
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 一般社団法人 日本聴覚医学会 ) 62 ( 5 ) 2019年
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Eotaxin-3 as a plasma biomarker for mucosal eosinophil infiltration in chronic rhinosinusitis
Yamada T.
Frontiers in Immunology ( Frontiers in Immunology ) 10 ( FEB ) 2019年
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Review Article アレルギー性鼻炎の診療・臨床研究に関する現状と今後の展望
山田 武千代
耳鼻咽喉科・頭頸部外科 ( 株式会社医学書院 ) 90 ( 10 ) 862 - 866 2018年09月
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Sato T.
Auris Nasus Larynx ( Auris Nasus Larynx ) 45 ( 4 ) 673 - 679 2018年08月
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Iikawa N.
International Journal of Molecular Sciences ( International Journal of Molecular Sciences ) 19 ( 7 ) 2018年07月
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An investigation on endoscopic laryngopharyngeal surgery and related outcomes
Kawasaki Y.
Wideochirurgia I Inne Techniki Maloinwazyjne ( Wideochirurgia I Inne Techniki Maloinwazyjne ) 13 ( 3 ) 394 - 400 2018年
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Precision Medicine for Allergic Airway Diseases
Yamada T.
Practica Oto-Rhino-Laryngologica ( Practica Oto-Rhino-Laryngologica ) 111 ( 3 ) 151 - 156 2018年
<p>Access to genome and biomolecular information has enabled us to understand the causes and development pathophysiologic processes of various diseases in detail at the molecular level. Precision medicine refers to the appropriate medical treatment and personal medical care selected based on precise classification of the patient's condition. In relation to individualized medicine in patients with allergic diseases, attempts have been made to identify biomarkers, genetic factors, relationships with environmental factors, and phenotypes for the selection of appropriate individualized therapies. Evidence from large-scale biological databases, proteomics, metabolomics, genomics, and diverse cellular assays is needed to precisely characterize patients for selecting tailor-made treatments. Herein, we summarize the indications for treatments such as macrolide, antibiotics, mepolizumab, benralizumab, omalizumab, dupulimab, lebrikizumab, and tezepelumab. Also, we have indicated the phenotypes suitable for treatment with histamine H<sub>1</sub> receptor antagonists, leukotriene receptor antagonists, and intranasal corticosteroids among patients with allergic rhinitis, and discussed the phenotypes, endotypes, and the possibility of precision medicine for patients with allergic airway diseases, including bronchial asthma, allergic rhinitis and rhinosinusitis, often encountered in clinical practice, as "One airway, one disease".</p>
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鈴木 真輔, 辻 正博, 椎名 和弘, 小谷野博正, 小泉 洸, 川嵜 洋平, 佐藤 輝幸, 山田 武千代
頭頸部外科 ( 特定非営利活動法人 日本頭頸部外科学会 ) 28 ( 2 ) 183 - 190 2018年
クマ外傷は顔面を含む頭頸部に多いとされ，しばしば複雑で重篤な損傷を伴う。今回われわれが経験したクマ外傷13例について報告し，クマ外傷の特徴と治療における注意点を考察する。対象となる13症例はいずれも顔面に外傷を伴っていたが，10例では顔面骨の骨折が認められ，うち1例では頭蓋底骨折を伴っていた。頭頸部以外では上肢に損傷が多く，3例では上肢や体幹の骨折が認められた。また3例では出血性ショックを合併していた。顔面の皮膚欠損を伴った4例では皮弁や植皮による欠損部の再建術を要した。クマ外傷への対応ではその特徴を理解するとともに，それぞれの損傷部位に応じた適切で迅速な治療が重要である。
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川嵜 洋平, 辻 正博, 鈴木 真輔, 山田 武千代
頭頸部外科 ( 特定非営利活動法人 日本頭頸部外科学会 ) 27 ( 3 ) 269 - 275 2018年
内視鏡的咽喉頭手術（ELPS）は早期癌に対して非常に有効な治療法であり，手術時間も短く不要な放射線化学療法を避ける事が可能となった。一方で，ELPSが普及する前は早期癌であっても放射線化学療法に頼らざるを得なかった。内視鏡の画像精度が上がっている為，以前に放射線化学療法で加療した患者の中下咽頭癌を早期の段階で見つける事が可能となっている。しかし，こうした患者に対してELPSを施行する時，手術操作が困難であったり，腫瘍が予想外に進展していたり，切除範囲が明確に解らない場合がある。われわれが経験した症例を検討し，根治照射後のELPSの問題点を明らかにしていく。
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鼻科手術のための検査
山田 武千代
Journal of Otorhinolaryngology Head and Neck surgery 34 1075 - 1082 2018年
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小児難治性疾患-難治性アレルギー性鼻炎-.
山田 武千代
Journal of Otorhinolaryngology Head and Neck surgery 34 1549 - 1553 2018年
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Yamada T.
Auris Nasus Larynx ( Auris Nasus Larynx ) 44 ( 4 ) 398 - 403 2017年08月
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新生児聴覚スクリーニングをパスした難聴児50例の検討:―秋田県16年間の経験から―
水野 知美, 中澤 操, 佐藤 輝幸, 高橋 辰, 阿部 隆, 浅野 義一, 山田 武千代
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ ( 日本聴覚医学会 ) 60 ( 5 ) 364 - 364 2017年