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学会（学術団体）・委員会 【 表示 ／ 非表示 】
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2020年-継続中
日本国
日本小児麻酔学会
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2019年-継続中
日本国
日本産科麻酔学会
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2015年04月-継続中
日本国
日本心臓麻酔学会
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2013年04月-継続中
日本国
日本臨床麻酔学会
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2013年04月-継続中
日本国
日本蘇生学会
研究等業績 【 表示 ／ 非表示 】
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Horikoshi Y, Goyagi T, Kudo R, Kodama S, Horiguchi T, Nishikawa T.
Journal of Clinical Anesthesia ( Journal of Clinical Anesthesia ) 38 111 - 116 2017年05月 [査読有り]
研究論文（学術雑誌） 単著
STUDY OBJECTIVE: To determine whether perioperative landiolol administration suppresses postoperative atrial fibrillation (AF) and the plasma cytokines elevation in patients undergoing esophageal cancer surgery. DESIGN: A prospective, randomized controlled trial. SETTING: Akita University Hospital, Akita, Japan, from April 2012 to January 2015. PATIENTS: Forty American Society of Anesthesiologists grade I-II patients undergoing elective esophagectomy. INTERVENTIONS: Patients were randomly divided into two groups, landiolol group (landiolol: 5μg/kg/min) and control group (the same volume of covered saline). Landiolol or saline was infused continuously from the induction of anesthesia until next morning. MEASUREMENTS: We examined the new onset of AF and sinus tachycardia, and measured plasma concentrations of cytokines (IL-1β, IL-6, IL-8, IL-10, and TNF-α) just before surgery, at the end of surgery, the next day, and 2days after surgery. Data (mean±SD) were analyzed using two-way ANOVA followed by the Bonferroni"s test for post hoc comparison; a P<0.05 was considered statistically significant. MAIN RESULTS: Demographic data were similar between the landiolol and the control groups. The incidence of AF was significantly lower in the landiolol group (1/19=5.3%) compared with the control group (7/20=35%) as well as sinus tachycardia (landiolol group, 0/19=0% vs. control group, 5/20=25%). Plasma IL-6 level at the end of surgery was significantly lower in the landiolol group compared with the control group, but the other plasma cytokines levels were similar between the two groups during the entire study period. CONCLUSIONS: Perioperative landiolol administration suppressed the incidence of new-onset of AF as well as sinus tachycardia, and the plasma IL-6 elevation in patients undergoing esophageal cancer surgery.
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Neuroprotective effects of combination of dexmedetomdine and hypothermia after asphyxial cardiac arrest in rats.
Horikoshi Y, Kimura T, Horiguchi T, Nishikawa T.
蘇生 2015年04月 [査読有り]
研究論文（学術雑誌） 単著
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MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury
Kimura T.
Neural Regeneration Research ( Neural Regeneration Research ) 18 ( 2 ) 311 - 312 2023年02月
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Rho/rock pathway and noncoding rnas: Implications in ischemic stroke and spinal cord injury
Kimura T.
International Journal of Molecular Sciences ( International Journal of Molecular Sciences ) 22 ( 21 ) 2021年11月
Ischemic strokes (IS) and spinal cord injuries (SCI) are major causes of disability. RhoA is a small GTPase protein that activates a downstream effector, ROCK. The up-regulation of the RhoA/ROCK pathway contributes to neuronal apoptosis, neuroinflammation, blood-brain barrier dysfunction, astrogliosis, and axon growth inhibition in IS and SCI. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), were previously considered to be non-functional. However, they have attracted much attention because they play an essential role in regulating gene expression in physiological and pathological conditions. There is growing evidence that ROCK inhibitors, such as fasudil and VX-210, can reduce injury in IS and SCI in animal models and clinical trials. Recently, it has been reported that miRNAs are decreased in IS and SCI, while lncRNAs are increased. Inhibiting the Rho/ROCK pathway with miRNAs alleviates apoptosis, neuroinflammation, oxidative stress, and axon growth inhibition in IS and SCI. Further studies are required to explore the significance of ncRNAs in IS and SCI and to establish new strategies for preventing and treating these devastating diseases.
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Komatsu H.
Japanese Journal of Anesthesiology ( Japanese Journal of Anesthesiology ) 67 ( 6 ) 604 - 607 2018年06月
We report a case in which the severity of tricuspid valve regurgitation was higher by transesophageal echocardiography prior to cardiopulmonary bypass compared with that of preoperative transthoracic echocardiography. Consequently, tricuspid annuloplasty was additionally performed. Intraoperative examination indicated higher severity than that estimated by preoperative assessment probably due to differences in the assessment site. When an anesthesiologist assesses tricuspid valve regurgitation during surgery using transesophageal echocardiogram, the anesthesiologist must carefully detect the site with the most severe regurgitatioa.
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小松 博, 堀越 雄太, 太田 由里恵
麻酔 = The Japanese journal of anesthesiology : 日本麻酔科学会準機関誌 ( 克誠堂出版 ) 67 ( 6 ) 604 - 607 2018年06月
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小松 博, 堀越 雄太, 太田 由里恵
麻酔 = The Japanese journal of anesthesiology : 日本麻酔科学会準機関誌 ( 克誠堂出版 ) 66 ( 10 ) 1071 - 1075 2017年10月
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科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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脳由来神経栄養因子に関連した術後認知機能障害の新たな機序解明
若手研究
研究期間: 2019年04月 - 2022年03月 代表者: 堀越 雄太
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脳由来神経栄養因子に関連した術後認知機能障害の新たな機序解明
若手研究
研究期間: 2019年04月 - 2022年03月
学会等発表 【 表示 ／ 非表示 】
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周術期ランジオロール投与による食道手術後の抗炎症作用と抗不整脈作用
堀越 雄太
日本麻酔科学会 第61回学術集会 2014年05月 - 2014年05月
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The suppressive effects of landiolol administration on the plasma IL-6 elevations and occurrences of arrhythmias in patients undergoing esophageal surgery.
Yuta Horikoshi
American Society of Anesthesiologists (ASA) 2013 Annual Meeting 2013年10月 - 2013年10月
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高齢POCDモデルラットの海馬においてproBDNFはBDNFと同様に発現量が減少する
堀越 雄太
日本麻酔科学会 第68回学術集会 2021年07月 - 2021年07月
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はじめてのEXIT (ex utero intrapartum treatment)
堀越 雄太 [招待有り]
日本小児麻酔学会第26回大会 2021年10月 - 2021年10月
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人工心肺離脱直後に発症したくも膜下出血をBIS値と瞳孔径の変化から早期に発見できた１症例
堀越 雄太
日本心臓麻酔学会第26回学術集会 2021年10月 - 2021年10月