明石 英雄 (アカシ ヒデオ)

AKASHI Hideo

写真a

所属

大学院医学系研究科(医学専攻等)  医学専攻  病態制御医学系  形態解析学・器官構造学講座

研究分野・キーワード

分子生物学

出身大学 【 表示 / 非表示

  •  
    -
    1997年03月

    東京大学   工学部   卒業

出身大学院 【 表示 / 非表示

  •  
    -
    2002年03月

    東京大学  工学系研究科  博士課程  修了

取得学位 【 表示 / 非表示

  • 東京大学 -  博士(工学)

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  • 2016年04月
    -
    継続中

    秋田大学   大学院医学系研究科(医学専攻等)   医学専攻   病態制御医学系   助教  

 

論文 【 表示 / 非表示

  • Bilateral accessory heads of biceps brachii muscle coexisting with brachioradial artery passing between two layers of atypical bicipital aponeurosis

    Zhou M.

    Translational Research in Anatomy ( Translational Research in Anatomy )  25   2021年11月

    DOI

  • An anomalous case of the flexor carpi radialis with an excessive muscular bundle

    Zhou M.

    Anatomical Science International ( Anatomical Science International )  95 ( 2 ) 293 - 296   2020年03月

    ISSN:14476959

    DOI

  • An anomalous case of the flexor carpi radialis with an excessive muscular bundle.

    Zhou M., Ishizawa A., Akashi H., Suzuki R., Kanatsu Y., Abe H., Bando Y.

    Anat. Sci. Int.   95   293 - 296   2020年03月  [査読有り]

    国内共著

  • Localization of ATP-sensitive K+ channel subunits in rat liver.

    Ming Zhou, Kiwamu Yoshikawa, Hideo Akashi, Mitsutaka Miura, Ryoji Suzuki, Tao-Sheng Li, Hiroshi Abe, Yoshio Bando

    World journal of experimental medicine   9 ( 2 ) 14 - 31   2019年12月

    BACKGROUND: ATP-sensitive K+ (KATP) channels were originally found in cardiac myocytes by Noma in 1983. KATP channels were formed by potassium ion-passing pore-forming subunits (Kir6.1, Kir6.2) and regulatory subunits SUR1, SU2A and SUR2B. A number of cells and tissues have been revealed to contain these channels including hepatocytes, but detailed localization of these subunits in different types of liver cells was still uncertain. AIM: To investigate the expression of KATP channel subunits in rat liver and their localization in different cells of the liver. METHODS: Rabbit anti-rat SUR1 peptide antibody was raised and purified by antigen immunoaffinity column chromatography. Four of Sprague-Dawley rats were used for liver protein extraction for immunoblot analysis, seven of them were used for immunohistochemistry both for the ABC method and immunofluorescence staining. Four of Wistar rats were used for the isolation of hepatic stellate cells (HSCs) and Kupffer cells for both primary culture and immunocytochemistry. RESULTS: Immunoblot analysis showed that the five kinds of KATP channel subunits, i.e. Kir6.1, Kir6.2, SUR1, SUR2A, and SUR2B, were detected in liver. Immunohistochemical staining showed that Kir6.1 and Kir6.2 were weakly to moderately expressed in parenchymal cells and sinusoidal lining cells, while SUR1, SUR2A, and SUR2B were mainly localized to sinusoidal lining cells, such as HSCs, Kupffer cells, and sinusoidal endothelial cells. Immunoreactivity for SUR2A and SUR2B was expressed in the hepatocyte membrane. Double immunofluorescence staining further showed that the pore-forming subunits Kir6.1 and/or Kir6.2 colocalized with GFAP in rat liver sections and primary cultured HSCs. These KATP channel subunits also colocalized with CD68 in liver sections and primary cultured Kupffer cells. The SUR subunits colocalized with GFAP in liver sections and colocalized with CD68 both in liver sections and primary cultured Kupffer cells. In addition, five KATP channel subunits colocalized with SE-1 in sinusoidal endothelial cells. CONCLUSION: Observations from the present study indicated that KATP channel subunits expressed in rat liver and the diversity of KATP channel subunit composition might form different types of KATP channels. This is applicable to hepatocytes, HSCs, various types of Kupffer cells and sinusoidal endothelial cells.

    DOI PubMed

  • Localization of ATP-sensitive K(+) channel subunits in rat liver.

    Zhou M., Yoshikawa K., Akashi H., Miura M., Suzuki R., Li T.S., Abe H., Bando Y.

    World J. Exp. Med.   9   14 - 31   2019年12月  [査読有り]

    国内共著

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  • 破格を作り出す遺伝子メカニズムの解明に向けた破格調査

    明石英雄, 周明, 鈴木良地, 阿部寛, 板東良雄

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   202   2019年

    未設定

    J-GLOBAL

  • 上腕二頭筋長頭の筋束欠損の報告

    周明, 明石英雄, 鈴木良地, 金津嘉徳, 石澤章光, 板東良雄

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   201   2019年

    未設定

    J-GLOBAL

  • 心房における刺激伝導系の探索

    竹内峻, 鈴木良地, 周明, 明石英雄, 金津嘉徳, 板東良雄

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   135   2019年

    未設定

    J-GLOBAL

  • 生理的食塩水局注による尺骨神経痛解除機構の解剖学的考察

    福川彩音, 鈴木良地, 周明, 明石英雄, 金津嘉徳, 板東良雄

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   128   2019年

    未設定

    J-GLOBAL

  • Alu配列を標的とした定量PCR法による古人骨由来ヒトゲノムDNAの高感度検出法の開発

    明石英雄, 船越広大, 周明, 鈴木良地, 阿部寛, 安達登

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   123rd   125   2018年

    未設定

    J-GLOBAL

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