Research Achievements - Original paper -

Unified total synthesis of colisporifungin, ophiotine and verruculin

Katsuki Akiyama, Kenshu Fujiwara

Tetrahedron ( Elsevier )  192   135123 - 135123   2025.12  [Refereed]

Research paper (journal)   Domestic Co-author

The total synthesis of colisporifungin, ophiotine and verruculin, possessing a common cyclic lipohexadepsipeptide framework including three D-amino acids and β-alanine, was successfully achieved by a unified, convergent route based on solution-phase peptide synthesis. The framework was assembled from a tripeptide fragment and a lipotridepsipeptide segment by a connection/cyclization process at the final stage, where a ring-forming condensation between the less-hindered β-alanine and the L-threonine residues effectively occurred. Initial introduction of the fatty acid moiety to D-glutamine to avoid unnecessary protecting group manipulations was also helpful for making the synthesis concise.

DOI

Total synthesis of selaginellin A

K. Fujiwara, T. Itagaki, T. Tokiwano

Tetrahedron Letters ( Tetrahedron Letters )  79   153295   2021.08  [Refereed]

Research paper (journal)   Domestic Co-author

The total synthesis of selaginellin A, isolated from Selaginella tamariscina, was achieved through an eight-step process including a Diels-Alder reaction, formation of a quinone methide moiety and dehydrogenative aromatization. The NMR spectra collected for different samples of synthetic selaginellin A initially showed irregular peak shapes and variable chemical shifts for the signals of the phenol-substituted quinone methide moiety under neutral conditions. After detailed NMR analysis, it was found that the addition of a trace amount of trifluoroacetic acid accelerated the tautomerism of the phenol-substituted quinone methide moiety and improved the reproducibility of the chemical shifts of synthetic selaginellin A.

DOI

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture

Y. Aki, Y. Katsumata, H. Kakihara, K. Nonaka, K. Fujiwara

PLoS ONE ( PLoS ONE )  16 ( 4 April 2021 ) e0250416   2021.04  [Refereed]

Research paper (journal)   Domestic Co-author

There is a continuous demand to improve monoclonal antibody production for medication supply and medical cost reduction. For over 20 years, recombinant Chinese hamster ovary cells have been used as a host in monoclonal antibody production due to robustness, high productivity and ability to produce proteins with ideal glycans. Chemical compounds, such as dimethyl sulfoxide, lithium chloride, and butyric acid, have been shown to improve monoclonal antibody production in mammalian cell cultures. In this study, we aimed to discover new chemical compounds that can improve cell-specific antibody production in recombinant Chinese hamster ovary cells. Out of the 23,227 chemicals screened in this study, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide was found to increase monoclonal antibody production. The compound suppressed cell growth and increased both cell-specific glucose uptake rate and the amount of intracellular adenosine triphosphate during monoclonal antibody production. In addition, the compound also suppressed the galactosylation on a monoclonal antibody, which is a critical quality attribute of therapeutic monoclonal antibodies. Therefore, the compound might also be used to control the level of the galactosylation for the N-linked glycans. Further, the structure-activity relationship study revealed that 2,5-dimethylpyrrole was the most effective partial structure of 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide on monoclonal antibody production. Further structural optimization of 2,5-dimethylpyrrole derivatives could lead to improved production and quality control of monoclonal antibodies.

DOI PubMed

Total synthesis of selaginellin S

Kenshu Fujiwara, Takaya Itagaki, Yoshihiko Kondo, Uichi Akiba, Tetsuo Tokiwano

Tetrahedron Letters ( Tetrahedron Letters )  61 ( 25 ) 152031   2020.06  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

An Approach to a 2-Hydroxy-3-phenyldibenzofuran Skeleton Based on Rh(PPh₃)₃Cl-Catalyzed [2+2+2] Cycloaddition Between a 1-Ethynyl-2-(Ethynyloxy)benzene and an (Alkoxyethynyl)benzene

Daisuke Sato, Kenshu Fujiwara, Yoshihiko Kondo, Uichi Akiba, Tetsuo Tokiwano

HETEROCYCLES   101 ( 2 ) 417 - 422   2020.01  [Refereed]

Research paper (journal)   Domestic Co-author

Molecular Wires with Controllable π‐Delocalization Incorporating Redox‐Triggered π‐Conjugated Switching Units.

Wataru Nojo, Hitomi Tamaoki, Yusuke Ishigaki, Ryo Katoono, Kenshu Fujiwara, Takanori Fukushima, Takanori Suzuki

ChemPlusChem   84 ( 6 ) 634 - 642   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

Total synthesis of kehokorins A and B.

Kenshu Fujiwara, Ryosuke Motousu, Daisuke Sato, Yoshihiko Kondo, Uichi Akiba, Takanori Suzuki, Tetsuo Tokiwano

Tetrahedron Letters   60   1299 - 1301   2019.03  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the cyclohexene segment of portimine.

Takafumi Saito, Kenshu Fujiwara, Yoshihiko Kondo, Uichi Akiba, Takanori Suzuki

Tetrahedron Letters   60   386 - 389   2019.01  [Refereed]

Research paper (journal)   Domestic Co-author

Transmission of Point Chirality to Axial Chirality for Strong Circular Dichroism in Triarylmethylium- o,o -Dimers.

Yusuke Ishigaki, Tomohiro Iwai, Yuki Hayashi, Aiichiro Nagaki, Ryo Katoono, Kenshu Fujiwara, Jun-ichi Yoshida, Takanori Suzuki

Synlett   29 ( 16 ) 2147 - 2154   2018.06  [Refereed]

Research paper (journal)   Domestic Co-author

Enhanced Circular Dichroism at Elevated Temperatures through Complexation-Induced Transformation of a Three-Layer Cyclophane with Dualistic Dynamic Helicity.

Ryo Katoono, Yudai Obara, Kenshu Fujiwara, Takanori Suzuki

Chemical Science   9   2222 - 2229   2018.04  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Supramolecular chiroptical switching of helical-sense preferences through the two-way intramolecular transmission of a single chiral source

R. Katoono, K. Kusaka, Y. Tanaka, K. Fujiwara, T. Suzuki

Organic & Biomolecular Chemistry   16 ( 7 ) 1167 - 1171   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

An improved synthesis of the C42-C52 segment of ciguatoxin 3C.

T. Saito, K. Fujiwara, Y. Sano, T. Sato, Y. Kondo, U. Akiba, Y. Ishigaki, R. Katoono, T. Suzuki

Tetrahedron Letters   59 ( 14 ) 1372 - 1376   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Double bond formation based on nitroaldol reaction and radical elimination: a prototype segment connection method for the total synthesis of nigricanoside A dimethyl ester.

T. Tsunoda, K. Fujiwara, S. Okamoto, Y. Kondo, U. Akiba, Y. Ishigaki, R. Katoono, T. Suzuki

Tetrahedron Letters   59 ( 19 ) 1846 - 1850   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Oxidative desulfurization of electron-donating 5,5,7,7-tetraaryl-5,7-dihydrodibenzo[c,e] thiepins and the related heterocycles: Generation of dicationic dyes upon two-electron oxidation.

T. Suzuki, T. Kuroda, H. Tamaoki, S, Higasa, T. Nehira, R. Katoono, Y. Ishigaki, K. Fujiwara, T. Fukushima, H. Yamada

Heterocycles   95 ( 2 ) 816 - 829   2017.11  [Refereed]

Research paper (journal)   Domestic Co-author

High selectivity and extractability of palladium from chloride leach liquors of an automotive catalyst residue by azothiacalix(4)arene derivative.

K. Senthil, U. Akiba, K. Fujiwara, F. Hamada, Y. Kondo

Hydrometallurgy   169   478 - 487   2017.10  [Refereed]

Research paper (journal)   Domestic Co-author

Highly Selective Separation and Recovery of Pd(II) from the Automotive Catalyst Residue with the Thiocarbamoyl substituted Azothiacalix[4]arene Derivative

K. Senthil, U. Akiba, K. Fujiwara, Y. Kondo

Separation Science and Technology (Philadelphia)   52 ( 8 ) 1365 - 1376   2017.02  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the ABCDEF-ring of ciguatoxin 3C

T. Sato, K. Fujiwara, K. Nogoshi, A. Goto, D. Domon, N. Kawamura, Y. Nomura, D. Sato, H. Tanaka, A. Murai, Y. Kondo, U. Akiba, R. Katoono, H. Kawai, T. Suzuki

Tetrahedron   73 ( 6 ) 703 - 726   2017.02  [Refereed]

Research paper (journal)   Domestic Co-author

Bis(diarylethenyl)-thiophenes, -bithiophenes, and -terthiophenes: a new series of electrochromic systems that exhibit a fluorescence response

Y. Ishigaki, H. Kawai, R. Katoono, K. Fujiwara, H. Higuchi, H. Kikuchi, T. Suzuki

Canadian Journal of Chemistry   95 ( 3 ) 243 - 252   2017.01  [Refereed]

Research paper (journal)   Domestic Co-author

New Heterocyclic Dithioether Ligands for Highly Selective Separation and Recovery of Pd(II) from Acidic Leach Liquors of Spent Automobile Catalyst

K. Senthil, U. Akiba, K. Fujiwara, F. Hamada, Y. Kondo

Industrial and Engineering Chemistry Research   56 ( 4 ) 1036 - 1047   2017.01  [Refereed]

Research paper (journal)   Domestic Co-author

Biological Activities of p-Terphenyl Compounds Isolated from Edible Mushrooms

T. Norikura, K. Fujiwara, H. Matsue, K. Iwai

FFI Journal   221 ( 3 ) 232 - 238   2016.08  [Refereed]

Research paper (journal)   Domestic Co-author

Redox-induced Conformational Changes in 1,3-Propylene- and m-Xylylenebis[5-(10-butyl-5,10-dihydrobenzo[a]indolo[2,3-c]carbazole)]: Twin-BIC Donors that Form Sandwich-like Dimeric Cations Exhibiting NIR Absorption

T. Suzuki, W. Nojo, Y. Sakano, R. Katoono, Y. Ishigaki, H. Ohno, K. Fujiwara

Chem. Lett.   45 ( 7 ) 720 - 722   2016.07  [Refereed]

Research paper (journal)   Domestic Co-author

Axially chiral dynamic redox system with a perfluorobiphenyl skeleton: Assembly to the optically pure dumbbell- or tripod-type electron donors undergoing facile 4e- and 6e-transfer

H. Tamaoki, R. Katoono, K. Fujiwara, T. Suzuki

Angew. Chem. Int. Ed.   55 ( 7 ) 2582 - 2586   2016.02  [Refereed]

Research paper (journal)   Domestic Co-author

Two-way chromic interconversion of the 2,2'-biphenol-6,6'-diyl dication with 5H,10H-dioxapyrene or 9H,10H-4,5-dihydroxyphenanthrene

Y. Sakano, R. Katoono, K. Fujiwara, T. Suzuki

Chem. Commun.   51 ( 76 ) 14303 - 14305   2015.10  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of Ganbajunins-D and -E and the Proposed Structure of Thelephantin-D

K. Fujiwara, K. Kushibe, T. Sato, T. Norikura, H. Matsue, K. Iwai, R. Katoono, T. Suzuki

Eur. J. Org. Chem.   2015 ( 26 ) 5798 - 5809   2015.09  [Refereed]

Research paper (journal)   Domestic Co-author

Controllability of dynamic double helices: quantitative analysis of the inversion of a screw-sense preference upon complexation

R. Katoono, S. Kawai, K. Fujiwara, T. Suzuki

Chem. Sci.   6 ( 11 ) 6592 - 6600   2015.08  [Refereed]

Research paper (journal)   Domestic Co-author

Dynamic Figure Eight Chirality: Multifarious Inversions of a Helical Preference Induced by Complexation

R. Katoono, Y. Tanaka, K. Kusaka, K. Fujiwara, T. Suzuki

J. Org. Chem.   80 ( 15 ) 7613 - 7625   2015.08  [Refereed]

Research paper (journal)   Domestic Co-author

Reversible Interconversion between 11,11,12,12-Tetraaryl-1,4-diaza/-1,4,5,8-tetraazaanthraquinodimethanes and Their Cationic Species: Electrochromic and Halochromic Responses

T. Suzuki, Y. Umezawa, Y. Sakano, H. Tamaoki, R. Katoono, K. Fujiwara

Chem. Lett.   44 ( 7 ) 905 - 907   2015.07  [Refereed]

Research paper (journal)   Domestic Co-author

New Insights into the Hexaphenylethane Riddle: Formation of an α,o-Dimer

Y. Uchimura, T. Takeda, R. Katoono, K. Fujiwara, T. Suzuki

Angew. Chem. Int. Ed.   54 ( 13 ) 4010 - 4013   2015.03  [Refereed]

Research paper (journal)   Domestic Co-author

Bis(10-methylacridinium)s as a versatile platform for redox active functionalized dyes and novel structures

T. Suzuki, T. Takeda, E. Ohta, K. Wada, R. Katoono, H. Kawai, K. Fujiwara

Chem. Rec.   15 ( 1 ) 280 - 294   2015.02  [Refereed]

Research paper (journal)   Domestic Co-author

Stereoselective Synthesis of the A-Ring of Armatol A from a Bromo-Substituted Chiral Building Block Based on Ireland-Claisen Rearrangement and Ring-Closing Olefin Metathesis

Y. Hirose, K. Fujiwara, Takafumi Saito, R. Katoono, T. Suzuki

Heterocycles   91 ( 1 ) 76 - 106   2015.01  [Refereed]

Research paper (journal)   Domestic Co-author

Bis(diarylethenyl)thiophene, -bithiophene, and -terthiophene: A New Series of Violene-Cyanine Hybrid-Type Electron Donors

Y. Ishigaki, H. Kawai, R. Katoono, K. Fujiwara, T. Suzuki

Heterocycles   90 ( 1 ) 136 - 143   2015.01  [Refereed]

Research paper (journal)   Domestic Co-author

Three-Way Output Molecular Response System based on Tetrakis(3,4-dialkoxyphenyl)-3,4-dihydro[5]helicenes: Perturbation of Properties by Long Alkyl Chains

Y. Ishigaki, S. Yoshida, H. Kawai, R. Katoono, K. Fujiwara, T. Fukushima, T. Suzuki

Heterocycles   90 ( 1 ) 126 - 135   2015.01  [Refereed]

Research paper (journal)   Domestic Co-author

Wurster's Blue-type Cation Radicals Framed in a 5,10-Dihydrobenzo[a]indolo[2,3-c]carbazole (BIC) Skeleton: Dual Electrochromism with Drastic Changes in UV/Vis/NIR and Fluorescence.

Suzuki, Takanori; Sakano, Yuto; Tokimizu, Yusuke; Miura, Youhei; Katoono, Ryo; Fujiwara, Kenshu; Yoshioka, Naoki; Fujii, Nobutaka; Ohno, Hiroaki.

Chem. Asian J.   9   1841 - 1846   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

Complexation-induced inversion of helicity by an organic guest in a dynamic molecular propeller based on a tristerephthalamide host with a two-layer structure.

Katoono, Ryo; Fujiwara, Kenshu; Suzuki, Takanori.

Chem. Commun.   50   5438 - 5440   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

Preparation and structure of acenaphthylene-1,2-diyldi(9-acridine) derivatives with a long C=C bond.

Takeda, Takashi; Uchimura, Yasuto; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Suzuki, Takanori.

Chem. Commun.   50   3924 - 3927   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis of Pectenotoxin-2.

Fujiwara, Kenshu; Suzuki, Yuki; Koseki, Nao; Aki, Yu-ichi; Kikuchi, Yuta; Murata, Shun-ichi; Yamamoto, Fuyuki; Kawamura, Mariko; Norikura, Toshio; Matsue, Hajime; Murai, Akio; Katoono, Ryo; Kawai, Hidetoshi; Suzuki, Takanori.

Angew. Chem. Int. Ed.   53   780 - 784   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

Expandability of ultralong C-C bonds: largely different C1-C2 bond lengths determined by low-temperature X-ray structural analyses on pseudopolymorphs of 1,1-bis(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)pyracene.

Suzuki, Takanori; Uchimura, Yasuto; Nagasawa, Fumika; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Murakoshi, Kei; Fukushima, Takanori; Nagaki, Aiichiro; Yoshida, Jun-ichi.

Chem. Lett.   43   86 - 88   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

Chiral memory units based on dynamic redox systems with a dibenzoxepinone skeleton: drastic change in racemization barrier and electrochemical bistability.

Wada, Kazuhisa; Chiba, Yuna; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Suzuki, Takanori.

Heterocycles   88   945 - 952   2014.01  [Refereed]

Research paper (journal)   Domestic Co-author

A new variant of fused cyclic ether synthesis based on Ireland-Claisen rearrangement and RCM.

Domon, Daisuke; Fujiwara, Kenshu; Kawamura, Natsumi; Katoono, Ryo; Kawai, Hidetoshi; Suzuki, Takanori.

Nat. Prod. Commun.   8   929 - 934   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

A stereoselective method for the construction of the C8'-O-C6'' ether of nigricanoside-A: synthesis of simple models for the C20 lipid chain/galactosyl glycerol segment.

Kinashi, Naoto; Fujiwara, Kenshu; Tsunoda, Takayuki; Katoono, Ryo; Kawai, Hidetoshi; Suzuki, Takanori.

Tetrahedron Lett.   54   4564 - 4567   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Time-integrated one-pot synthesis, X-ray structure, and redox properties of electrochromic 1,3-diarylisobenzofurans.

Hamura, Toshiyuki; Nakayama, Ryosuke; Hanada, Keisuke; Sakano, Yuto; Katoono, Ryo; Fujiwara, Kenshu; Suzuki, Takanori.

Chem. Lett.   42   1244 - 1246   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Geometrical remote steric effects in 4,5-disubstituted-9,10-dihydrophenanthrenes: expansion of prestrained C9-C10 bond in di(spiroacridan) derivatives.

Wada, Kazuhisa; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Suzuki, Takanori.

Chem. Lett.   42   1194 - 1196   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Preparation, properties, and X-ray structures of bis(10-methyl-9-methyleneacridan)-type electron donors with a thiophene, bithiophene, or terthiophene skeleton: redox switching of thiophene-thienoquinoid structure accompanied by UV-vis-NIR electrochromic

Suzuki, Takanori; Hoshiyama, Yuuki; Wada, Kazuhisa; Ishigaki, Yusuke; Miura, Youhei; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Fukushima, Takanori.

Chem. Lett.   42   1004 - 1006   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

5,10-dihydrobenzo[a]indolo[2,3-c]carbazole: a highly fluorescent disk-shaped electron donor exhibiting dual UV-vis-NIR and fluorescence spectral changes upon electrolysis.

Suzuki, Takanori; Tokimizu, Yusuke; Sakano, Yuto; Katoono, Ryo; Fujiwara, Kenshu; Naoe, Saori; Fujii, Nobutaka; Ohno, Hiroaki.

Chem. Lett.   42   1001 - 1003   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

A C3-symmetric chiroptical molecular propeller based on hexakis(phenylethynyl)benzene with a threefold terephthalamide: stereospecific propeller generation through the cooperative transmission of point chiralities on the host and guest upon complexation.

Katoono, Ryo; Kawai, Hidetoshi; Ohkita, Masakazu; Fujiwara, Kenshu; Suzuki, Takanori.

Chem. Commun.   49   10352 - 10354   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Oxidative conversion of tetraaryldihydrodibenzothiepins into elemental sulfur and stable cationic dyes accompanied by dual UV-vis and CD spectral changes.

Suzuki, Takanori; Kuroda, Takuma; Tamaoki, Hitomi; Higasa, Sho; Katoono, Ryo; Fujiwara, Kenshu; Fukushima, Takanori; Yamada, Hidetoshi.

Chem. Lett.   42   706 - 708   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Redox switching of conjugation length using 9,9,10,10-tetraaryl-9,10-dihydrophenanthrene as an ON/OFF unit: preparation, X-ray structure, and redox properties of perfluorobiphenyl derivative and its SNAr reactions to π-extended analogues.

Suzuki, Takanori; Tamaoki, Hitomi; Katoono, Ryo; Fujiwara, Kenshu; Ichikawa, Junji; Fukushima, Takanori.

Chem. Lett.   42   703 - 705   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Hydrindacene-Based Acetylenic Macrocycles with Horizontally and Vertically Ordered Functionality Arrays.

Kawai, Hidetoshi; Utamura, Tatsuya; Motoi, Erina; Takahashi, Tomoko; Sugino, Hiroyoshi; Tamura, Manabu; Ohkita, Masakazu; Fujiwara, Kenshu; Saito, Takao; Tsuji, Takashi; Suzuki, Takanori.

Chem. Eur. J.   19   4513 - 4524   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

p-Terphenyl Derivatives from the Mushroom Thelephora

Norikura, T., Fujiwara, K., Yanai, T., Sano, Y., Sato, T., Tsunoda, T., Kushibe, K., Todate, A., Morinaga, Y., Iwai, K., Matsue, H.

J. Agric. Food Chem.   61 ( 6 ) 1258 - 1264   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

An Ireland-Claisen rearrangement/RCM based approach for the construction of the EF-ring of ciguatoxin 3C

Nogoshi, K., Domon, D., Fujiwara, K., Kawamura, N., Katoono, R., Kawai, H., Suzuki, T.

Tetrahedron Lett.   54 ( 7 ) 676 - 680   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

7,7,8,8-Tetraaryl-o-quinodimethane Stabilized by Dibenzo Annulation: A Helical π-Electron System That Exhibits Electrochromic and Unique Chiroptical Properties

Suzuki, T., Sakano, Y., Iwai, T., Iwashita, S., Miura, Y., Katoono, R., Kawai, H., Fujiwara, K., Tsuji, Y., Fukushima, T.

Chem.--Eur. J.     2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stable neutral radicals based on the polyazaacene skeleton that exhibit high electrochemical amphotericity

Miura, Y., Chiba, H., Katoono, R., Kawai, H., Fujiwara, K., Suzuki, S., Okada, K., Suzuki, T.

Tetrahedron Lett.   53 ( 48 ) 6561 - 6564   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Effects of Axle-Core, Macrocycle, and Side-Station Structures on the Threading and Hydrolysis Processes of Imine-Bridged Rotaxanes

Sugino, H., Kawai, H., Umehara, T., Fujiwara, K., Suzuki, T.

Chem.--Eur. J.   18 ( 43 ) 13722 - 13732   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Chirality sensing based on changes in conformation of dynamic terephthalamide hosts: propeller-, double-arm-, and figure-of-eight-shaped hosts

Katoono, R., Kawai, H., Fujiwara, K., Suzuki, T.

有機合成化学協会誌   70 ( 6 ) 640 - 650   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Nonadditive substituent effects on expanding prestrained C-C bond in crystal: X-ray analyses on unsymmetrically substituted tetraarylpyracenes prepared by a flow microreactor method

Suzuki, T., Uchimura, Y., Ishigaki, Y., Takeda, T., Katoono, R., Kawai, H., Fujiwara, K., Nagaki, A., Yoshida, J.

Chem. Lett.   41 ( 5 ) 541 - 543   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis of Thelephantin O, Vialinin A/Terrestrin A, and Terrestrins B-D

Fujiwara, K., Sato, T., Sano, Y., Norikura, T., Katoono, R., Suzuki, T., Matsue, H.

J. Org. Chem.   77 ( 11 ) 5161 - 5166   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Molecular gyroscope with a trans-cyclohexane-1,4-diimine rotor unit: isolation and characterization of a geometric isomer as a formal intermediate of hindered rotation

Sugino, H., Kawai, H., Fujiwara, K., Suzuki, T.

Chem. Lett.   41 ( 1 ) 79 - 81   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Induced preference for axial chirality in a triarylmethylium o,o-dimer upon complexation with natural γ-cyclodextrin: strong ECD signaling and fixation of supramolecular chirality to molecular chirality

Suzuki, T., Tamaoki, H., Wada, K., Katoono, R., Nehira, T., Kawai, H., Fujiwara, K.

Chem. Commun.   48 ( 22 ) 2812 - 2814   2012.01  [Refereed]

Research paper (journal)   Domestic Co-author

Construction of main-chain type oligorotaxanes and their switching properties: controlled dynamic behavior by imine-bonding formation and cleavage.

Sugino, H., Kawai, H., Fujiwara, K., Suzuki, T.

Kobunshi Ronbunshu   68 ( 12 ) 795 - 803   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

Hysteretic tricolor electrochromic systems based on the dynamic redox properties of unsymmetrically substituted dihydrophenanthrenes and biphenyl-2,2'-diyl dications: efficient precursor synthesis by a flow microreactor method.

Ishigaki, Y., Suzuki, T., Nishida, J.-i., Nagaki, A., Takabayashi, N., Kawai, H., Fujiwara, K., Yoshida, J.-i.

Materials   4   1906 - 1926   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

1,4-Diaryl-7,10-dimethoxyquinoxalino[2,3-b]quinoxalines and their dihydro derivatives: redox switching of NIR absorption and fluorescence.

Miura, Y., Kawai, H., Fujiwara, K., Suzuki, T.

Chemistry Letters   40 ( 9 ) 975 - 977   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

Improved synthesis of C8-C20 segment of pectenotoxin-2.

Fujiwara, K., Suzuki, Y., Koseki, N., Murata, S.-i., Murai, A., Kawai, H., Suzuki, T.

Tetrahderon Letters   52 ( 43 ) 5589 - 5592   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

Anticancer Activities of Thelephantin O and Vialinin A Isolated from Thelephora aurantiotincta.

Norikura, T., Fujiwara, K., Narita, T., Yamaguchi, S., Morinaga, Y., Iwai, K., Matsue, H.

J. Agric. Food Chem.   59 ( 13 ) 6974 - 6979   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the C22-C37 segment of prorocentin.

A. Takemura, Y. Katagiri, K. Fujiwara, H. Kawai, and T. Suzuki

Tetrahedron Letters   52 ( 11 ) 1222 - 1224   2011.01  [Refereed]

Research paper (journal)   Domestic Co-author

Model studies for the stereoselective construction of the BC-ring of armatol F based on Ireland-Claisen rearrangement and relay ring-closing olefin metathesis

K. Fujiwara, K. Tanaka, Y.Katagiri, H. Kawai, and T. Suzuki

Tetrahedron Letters   51 ( 34 ) 4543 - 4546   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Studies toward the total synthesis of armatol F: stereoselective construction of the C6 and C7 stereocenters and formation of the A-ring skeleton

K. Fujiwara, Y. Hirose, D. Sato, H. Kawai, and T. Suzuki

Tetrahedron Letters   51 ( 32 ) 4263 - 4266   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Drastic change in racemization barrier upon redox reactions: novel chiral-memory units based on dynamic redox systems

T. Suzuki, K. Wada, Y. Ishigaki, Y. Yoshimoto, E. Ohta, H. Kawai, and K. Fujiwara

Chem. Commun.   46 ( 23 ) 4100 - 4102   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Intramolecular chirality transfer in trans-5,6-diaryl-5,6-dihydro-1,10-phenanthroline-5,6-diols: solvato- and halochromic responses by circular dichroism.

T. Suzuki, Y. Miura, T. Nehira, H. Kawai, and K. Fujiwara

Chemistry Letters   39 ( 7 ) 695 - 697   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Halochromic chiroptical response of novel bis(9-acridinyl)-type fluorophores with a helical pi-framework.

T. Nehira, Y. Yoshimoto, K. Wada, H. Kawai, K. Fujiwara, and T. Suzuki

Chemistry Letters   39 ( 3 ) 165 - 167   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Phenanthrene-4,5-diylbis(10-methylacridinium) with a short C+ -- C+ contact: preparation, molecular structure, redox properties, and electrochromic interconversion with dihydropyrene derivative

T. Suzuki, Y. Yoshimoto, K. Wada, T. Takeda, H. Kawai, and K. Fujiwara

Heterocycles   80 ( 1 ) 149 - 155   2010.01  [Refereed]

Research paper (journal)   Domestic Co-author

Dynamic Molecular Propeller: Supramolecular Chirality Sensing by Enhanced Chiroptical Response through the Transmission of Point Chirality to Mobile Helicity

R. Katoono, H. Kawai, K. Fujiwara, and T. Suzuki

Journal of the American Chemical Society   131 ( 46 ) 16896 - 16904   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Multi-Input/Multi-Output Molecular Response System Based on the Dynamic Redox Behavior of 3,3,4,4-Tetraaryldihydro[5]helicene Derivatives: Reversible Formation/Destruction of Chiral Fluorophore and Modulation of Chiroptical Properties by Solvent Polarity

T. Suzuki, Y. Ishigaki, T. Iwai, H. Kawai, K. Fujiwara, H. Ikeda, Y. Kano, and K. Mizuno

Chemistry--A European Journal   15 ( 37 ) 9434 - 9441   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

4,5-bis(diarylmethylene)-1,3-dithiole: a novel helical electron donor exhibiting electrochromic behavior

T. Suzuki, S. Mikuni, Y. Ishigaki, H. Higuchi, H. Kawai, and K. Fujiwara

Chemistry Letters   38 ( 7 ) 748 - 749   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Preparation and X-ray structures of trans-5,6-diaryl-5,6-dihydro-1,10-phenanthroline-5,6-diols: formation of supramolecular rod by hydrogen bonds

T. Suzuki, Y. Miura, R. Tamaki, H. Kawai, and K. Fujiwara

Chemistry Letters   38 ( 7 ) 670 - 671   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Negligible diradical character for the ultralong C-C bond in 1,1,2,2-tetraarylpyracene derivatives at room temperature

T. Takeda, H. Kawai, R. Herges, E. Mucke, Y. Sawai, K. Murakoshi, K. Fujiwara, and T. Suzuki

Tetrahedron Letters   50 ( 26 ) 3693 - 3697   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Intramolecular methylacridan-methylacridinium complexes with a phenanthrene-4,5-diyl or related skeleton: geometry-property relationships in isolable C-H bridged carbocations

T. Suzuki, Y. Yoshimoto, T. Takeda, H. Kawai, and K. Fujiwara

Chemistry--A European Journal   15 ( 9 ) 2210 - 2216   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stereoselective construction of an anti-beta -alkoxy ether by Ireland-Claisen rearrangement for medium-ring ether synthesis

K. Fujiwara, N. Kawamura, H. Kawai, and T. Suzuki

Tetrahedron Letters   50 ( 11 ) 1236 - 1239   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Unprecedented four-way-output molecular response system based on biphenyl-2,2'-diyldiacridiniums: induction of axial chirality through intramolecular hydrogen bonds between chiral amide groups

T. Suzuki, K. Ohta, T. Nehira, H. Higuchi, E. Ohta, H. Kawai, and K. Fujiwara

Tetrahedron Letters   49 ( 5 ) 772 - 776   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Designed molecular propellers based on tetraarylterephthalamide and their chiroptical properties induced by biased helicity through transmission of point chirality

R. Katoono, H. Kawai, K. Fujiwara, and T. Suzuki

Chemical Communications   ( 40 ) 4906 - 4908   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Four-way-output molecular response system based on the dihydrodibenzo[c,g]phenanthrene skeleton: modulation of CD and FDCD activity by acid and electron-transfer

E. Ohta, T. Nehira, H. Kawai, K. Fujiwara, and T. Suzuki

Tetrahedron Letters   49 ( 5 ) 777 - 781   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the ABC-ring models of goniodomin A: preference for the unnatural configuration at C11 of the BC-ring in a non-macrocyclic model system

T. Katagiri, K. Fujiwara, H. Kawai, and T. Suzuki

Tetrahedron Letters   49 ( 20 ) 3242 - 3247   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry

T. Katagiri, K. Fujiwara, H. Kawai, and T. Suzuki

Tetrahedron Letters   49 ( 2 ) 233 - 237   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Ultralong carbon-carbon bonds in dispirobis(10-methylacridan) derivatives with an acenaphthene, pyracene, or dihydropyracylene skeleton

H. Kawai, T. Takeda, K. Fujiwara, M. Wakeshima, Y. Hinatsu, and T. Suzuki

Chemistry--A European Journal   14 ( 19 ) 5780 - 5793   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Concise stereoselective synthesis of cis-3-alkoxy-2-carbomethoxy medium-ring oxacycles from (R)-3-(3-butenyl)-4-propynoyloxazolidin-2-one

D. Sato, K. Fujiwara, H. Kawai, and T. Suzuki

Tetrahedron Letters   49 ( 9 ) 1514 - 1517   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Ultralong C-C bonds in hexaphenylethane derivatives

T. Suzuki, T. Takeda, H. Kawai, and K. Fujiwara

Pure and Applied Chemistry   80 ( 3 ) 547 - 553   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Entropy- and Hydrolytic-Driven Positional Switching of Macrocycle between Imine- and Hydrogen-Bonding Stations in Rotaxane-Based Molecular Shuttles

T. Umehara, H. Kawai, K. Fujiwara, and T. Suzuki

Journal of the American Chemical Society   130 ( 42 ) 13981 - 13988   2008.01  [Refereed]

Research paper (journal)   Domestic Co-author

Electrochiroptical systems based on biphenyl-2,2'-diyl-type dicationic dyes: strong chiroptical signals through the transmission of point chirality to axial chirality

T. Suzuki, T. Iwai, E. Ohta, H. Kawai, and K. Fujiwara

Tetrahedron Letters   48 ( 20 ) 3599 - 3603   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Polycavernoside C and C2, the new analogs of the human lethal toxin polycavernoside A, from the red alga, Gracilaria edulis,

M. Yotsu-Yamashita, K. Abe, T. Seki, K. Fujiwara, and T. Yasumoto

Tetrahedron Letters   48 ( 13 ) 2255 - 2259   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Multi-input-multi-output molecular response system based on dynamic redox behavior of hexaphenylethane-type electron donors with the tetrahydrophenanthrazepine skeleton: strong chiroptical signals through the transmission of point chirality to helicity

T. Suzuki, S. Tanaka, H. Kawai, and K. Fujiwara

Chemistry--An Asian Journal   2 ( 1 ) 171 - 177   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Chromic and fluorescence response system based on the dihydrophenanthroline-bipyridine skeleton: dynamic redox behavior and metal binding properties

T. Suzuki, R. Tamaki, E. Ohta, T. Takeda, H. Kawai, K. Fujiwara, and M. Kato

Tetrahedron Letters   48 ( 22 ) 3823 - 3827   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of prelaureatin, laurencin, and the medium-ring ether parts of ciguatoxins

K. Fujiwara

J. Synth. Org. Chem. Jpn.   65 ( 5 ) 502 - 510   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Dynamic redox systems as electrochromic materials: bistability and advanced response

T. Suzuki, E. Ohta, H. Kawai, K. Fujiwara, and T. Fukushima

Synlett   ( 6 ) 851 - 869   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis and relative stereochemistry of the A- and F-rings of goniodomin A

K. Fujiwara, J. Naka, T. Katagiri, D. Sato, H. Kawai, and T. Suzuki

Bulletin of the Chemical Society of Japan   80 ( 6 ) 1173 - 1186   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the C8-C20 and C21-C30 segments of pectenotoxin 2

K. Fujiwara, Y.-i. Aki, F. Yamamoto, M. Kawamura, M. Kobayashi, A. Okano, D. Awakura, S. Shiga, A. Murai, H. Kawai, and T. Suzuki

Tetrahedron Letters   48 ( 26 ) 4523 - 4527   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Intramolecular triarylmethane-triarylmethylium complexes with a naphthalene-1,8-diyl skeleton: isolation, structure, and reactivities of the C-H-bridged carbocations

T. Takeda, H. Kawai, K. Fujiwara, and T. Suzuki

Chemistry--A European Journal   13 ( 28 ) 7915 - 7925   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the EF-Ring of Ciguatoxin 3C Based on the [2,3]-Wittig Rearrangement and Ring-Closing Olefin Metathesis

A. Goto, K. Fujiwara, A. Kawai, H. Kawai, and T. Suzuki

Organic Letters   9 ( 26 ) 5373 - 5376   2007.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the common FGHI-ring part of ciguatoxins.

A. Takizawa, K. Fujiwara, E. Doi, A. Murai, H. Kawai, and T. Suzuki

Tetrahedron Lett.   47 ( 5 ) 747 - 751   2006.01  [Refereed]

Research paper (journal)   Domestic Co-author

The first stable tetraarylacenaphthenequinodimethanes: Preparation, highly deformed structure, and reversible interconversion with acenaphthylene-5,6-diyl dicationic dyes

T. Suzuki, S. Iwashita, T. Yoshino, H. Kawai, K. Fujiwara, M. Ohkita, T. Tsuji, K. Ono, and M. Takenaka

Tetrahedron Lett.   47   467 - 471   2006.01  [Refereed]

Research paper (journal)   Domestic Co-author

Convergent synthesis of the common FGHI-ring part of ciguatoxins.

A. Takizawa, K. Fujiwara, E. Doi, A. Murai, H. Kawai, and T. Suzuki

Tetrahedron   62 ( 31 ) 7408 - 7435   2006.01  [Refereed]

Research paper (journal)   Domestic Co-author

Dynamic covalently bonded rotaxanes cross-linked imine bonds between the axle and ring: inverse temperature dependence of subunit mobility.

H. Kawai, T. Umehara, K. Fujiwara, T. Tsuji, and T. Suzuki

Angew. Chem. Int. Ed.   45 ( 26 ) 4281 - 4286   2006.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stereospecific change in conformation upon complexation of an exoditopic tetraamide host with a bis(ammonium) guset: chiral recognition and strong CD signaling

Katoono, R., Kawai, H., Fujiwara, K., Suzuki, T.

Chem. Commun.   ( 41 ) 5154 - 5156   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Exceptionally large difference in bond length among conformational isomorphs of a hexaphenylethane derivative with a dispiropyracene skeleton

Kawai, H., Takeda, T., Fujiwara, K., Inabe, T., Suzuki, T.

Crystal Growth & Design   5 ( 6 ) 2256 - 2260   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Tetracyanoanthraquinodimethanes with a Chiral Amide Group: Preparation, Properties, and Charge-Transfer Photochirogenetic Reaction with 1,2-Dianisylacenaphthene-1,2-diol

Suzuki, T., Ichioka, K., Higuchi, H., Kawai, H., Fujiwara, K., Ohkita, M., Tsuji, T., Takahashi, Y.

J. Org. Chem.   70 ( 14 ) 5592 - 5598   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the EF-ring segment of ciguatoxin CTX1B based on novel regioselective reduction of unsaturated cyanohydrins and ring-closing olefin metathesis

Takemura, A., Fujiwara, K., Shimawaki, K., Murai, A., Kawai H., Suzuki, T.

Tetrahedron   61 ( 31 ) 7392 - 7419   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of (+)-laurencin via ring expansion of a C-glycoside derivative

Fujiwara, K., Yoshimoto, S., Takizawa, A., Souma, S.-i., Mishima, H., Murai, A., Kawai, H., Suzuki, T.

Tetrahedron Lett.   46 ( 40 ) 6819 - 6822   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stereoselective synthesis of cis- and trans-2,3-disubstituted eight-membered medium-ring ethers based on Ireland-Claisen rearrangement of 3-alkoxy-2-propenyl glycolate esters and ring-closing olefin metathesis

Fujiwara, K., Goto, A., Sato, D., Kawai, H., Suzuki, T.

Tetrahedron Lett.   46 ( 20 ) 3465 - 3468   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Convergent synthesis of the IJKLM-ring part of ciguatoxin CTX3C

Domon, D., Fujiwara, K., Murai, A., Kawai, H., Suzuki, T.

Tetrahedron Lett.   46 ( 48 ) 8285 - 8288   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Multipoint Recognition of Catecholamines by Hydrindacene-Based Receptors Accompanied by the Complexation-Induced Conformational Switching

Kawai, H., Katoono, R., Fujiwara, K., Tsuji, T., Suzuki, T.

Chem. Eur. J.   11 ( 3 ) 815 - 824   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Butane-1,4-diyl dications stabilized by steric factors: electrochiroptical response systems based on reversible interconversion between dihydro[5]helicene-type electron acceptors and electron-donating 1,1'-binaphthyls

Ohta, E., Higuchi, H., Kawai, H., Fujiwara, K., Suzuki, T.

Org. Biomol. Chem.   3 ( 16 ) 3024 - 3031   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the common left-half part of pectenotoxins

Fujiwara,K., Kobayashi, M., Yamamoto, F., Aki, Y.-i., Kawamura, M., Awakura, D., Amano, S., Okano, A., Murai, A., Kawai , H., Suzuki, T.

Tetrahedron Lett.   46 ( 30 ) 5067 - 5069   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Isolation and Low-Temperature X-ray Analysis of Intramolecular Triarylmethane-Triarylmethylium Complex: Preference for a C-H-Bridged Unsymmetric Structure Exhibiting a Facile 1,5-Hydride Shift and Charge-Transfer Interaction

Kawai, H., Takeda, T., Fujiwara, K., Suzuki, T.

J. Am. Chem. Soc.   127 ( 35 ) 12172 - 12173   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the C42-C52 part of ciguatoxin CTX3C

Domon, D., Fujiwara, K., Ohtaniuchi, Y., Takezawa, A., Takeda, S., Kawasaki, H., Murai, A., Kawai, H., Suzuki, T.

Tetrahedron Lett.   46 ( 48 ) 8279 - 8283   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

peri-Interaction between Diarylmethyl and Diarylmethylium Units in 1,8-Disubstituted Naphthalenes: Preference of Localized Structure for the C-H Bridged Carbocation

Kawai, H., Nagasu, T., Takeda, T., Fujiwara, K., Tsuji, T., Ohkita, M., Nishida, J.-i. and Suzuki, T.

Tetrahedron Lett.   45 ( 23 ) 4553 - 4558   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Convergent Synthesis of the ABCDE-Ring Part of Ciguatoxin CTX3C

Fujiwara, K., Goto, A., Sato, D., Ohtaniuchi, Y., Tanaka, H., Murai, A., Kawai, H. and Suzuki, T.

Tetrahedron Lett.   45 ( 38 ) 7011 - 7014   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

[10]Paracyclophanediamides and Their Octadehydro Derivatives: Novel Exotopic Receptors with Hydrogen-Bonding Sites on the Bridge

Katoono, R., Kawai, H., Fujiwara, K. and Suzuki, T.

Tetrahedron Lett.   45 ( 46 ) 8455 - 8459   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Dynamic Redox Systems Based on Bis(spiroxanthene)-Type Donors with a Polycyclic Aromatic Hydrocarbons: Preparation, X-Ray Structures and Electrochromic Response with Fluorescence Change

Suzuki, T., Tanaka, S., Higuchi, H., Kawai, H. and Fujiwara, K.

Tetrahedron Lett.   45 ( 46 ) 8563 - 8567   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Novel Branched Ether Formation via Conjugate Reduction of an Unsaturated Cyanohydrin Derivative and Its Synthetic Application to the EF-Ring Segment of Ciguatoxin

Takemura, A., Fujiwara, K., Murai, A., Kawai, H. and Suzuki, T.

Tetrahedron Lett.   45 ( 41 ) 7567 - 7571   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Positive Homotropic Allosteric Binding of Benzenediols in a Hydrindacene-Based Exoditopic Receptor: Cooperativity in Amide Hydrogen Bonding

Kawai, H., Katoono, R., Nishimura, K., Matsuda, S., Fujiwara, K., Tsuji, T. and Suzuki, T.

J. Am. Chem. Soc.   126 ( 16 ) 5034 - 5035   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Pyrazino-Tetracyanonaphthoquinodimethanes: Sterically Deformed Electron Acceptors Affording Zwitterionic Radicals

Suzuki, T., Miyanari, S., Kawai, H., Fujiwara, K., Fukushima, T., Miyashi, T. and Yamasiha, Y.

Tetrahedron   60 ( 9 ) 1997 - 2003   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Preparation, Properties, and X-Ray Structures of 5,5'-Bi(8-aminoquinoxalyl)s: Novel Wurster-Type Electron Donors with a Heterobiaryl Skeleton

Suzuki, T., Saito, M., Kawai, H., Fujiwara, K. and Tsuji, T.

Tetrahedron Lett.   45 ( 2 ) 329 - 333   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Formal Total Synthesis of Hemibrevetoxin B by a Convergent Strategy

Fujiwara, K., Sato, D., Watanabe, M., Morishita, H., Murai, A., Kawai, H. and Suzuki, T.

Tetrahedron Lett.   45 ( 27 ) 5243 - 5246   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

First stable 7,7,8,8-tetraaryl-o-quinodimethane: isolation, X-ray structure, electrochromic response of 9,10-bis(dianisylmethylene)-9,10-dihydrophenanthrene

Iwashita, S., Ohta, E., Higuchi, H., Kawai, H., Fujiwara, K., Ono, K., Takenaka, M. and Suzuki, T.

Chem. Commun.   ( 18 ) 2076 - 2077   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Three-Way-Output Response System by Electric Potential: UV-Vis, CD, and Fluorescence Spectral Changes upon Electrolysis of the Chiral Ester of Tetracyanoanthraquinodimethane

Higuchi, H., Ichioka, K., Kawai, H., Fujiwara, K., Ohkita, M., Tsuji, T. and Suzuki, T.

Tetrahedron Lett.   45 ( 15 ) 3027 - 3030   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Short Nonbond and Long C-C Bond in Naphthalene-1,8-diylbis(10-methylacridinium) and the Corresponding Hexaphenylethane derivative: A New Electrochromic Pair Exhibiting Dynamic Redox Properties

Kawai, H., Takeda, T., Fujiwara, K. and Suzuki, T.

Tetrahedron Lett.   45 ( 45 ) 8289 - 8293   2004.01  [Refereed]

Research paper (journal)   Domestic Co-author

Electrochiroptical Responce of 2,2'-(2,2-Diarylethenyl)binaphthyl-type Electron Donors that Undergo Reversible C-C Bond Formation/Breaking Upon Two-Electron Transfer

Higuchi, H., Oota, E., Kawai, H., Fujiwara, K., Tsuji, T., and Suzuki, T.

J. Org. Chem.   68 ( 17 ) 6605 - 6610   2003.01  [Refereed]

Research paper (journal)   Domestic Co-author

A Novel Redox Switch for Fluorescence: Drastic UV-Vis and Fluorescence Spectral Changes upon Electrolysis of a Hexaphenylethane Derivative of 10,10 '-Dimethylbiacridan

Suzuki, T., Migita, A., Higuchi, H., Kawai, H., Fujiwara, K. and Tsuji, T.

Tetrahedron Lett.   44 ( 36 ) 6837 - 6840   2003.01  [Refereed]

Research paper (journal)   Domestic Co-author

4,7-Bis(dimethylamino)benzimidazoles and Twin-type Derivatives: Reversible Two-stage Redox System Modulated by Proton-transfer

Suzuki, T., Tsubata, Y., Obana, Y., Fukushima, T., Miyashi, T., Saito, M., Kawai, H., Fujiwara, K. and Akiyama, K.

Tetrahedron Lett.   44 ( 43 ) 7881 - 7884   2003.01  [Refereed]

Research paper (journal)   Domestic Co-author

Formation of Keto-carbenium from 1,2,2-Triarylacenaphten-1-ols by Breaking a Long C-C Bond: Unusual Alcohol Protonolysis Accompanied by Formal Hydride Abstraction

Suzuki, T., Nagasu, T., Kawai, H., Fujiwara, K. and Tsuji, T.

Tetrahedron Lett.   44 ( 32 ) 6095 - 6098   2003.01  [Refereed]

Research paper (journal)   Domestic Co-author

Syntheses of the D-, E-, F-, and I-Ring Parts of Ciguatoxin by a Common Strategy Starting from Tri-O-acetyl-D-glucal

Fujiwara, K., Koyama, Y., Doi, E., Shimawaki, K., Ohtaniuchi, Y., Takemura, A., Souma, S.-i., and Murai, A.

Synlett   ( 9 ) 1496 - 1499   2002.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the AB-Ring Segment for the Convergent Construction of the Left Half in Ciguatoxin

Tanaka, H., Kawai, K., Fujiwara, K., and Murai, A.

Tetrahedron   58 ( 50 ) 10017 - 10031   2002.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis of Prelaureatin

Fujiwara, K., Souma, S.-i., Mishima, H., and Murai, A.

Synlett   ( 9 ) 1493 - 1495   2002.01  [Refereed]

Research paper (journal)   Domestic Co-author

Convergent Synthesis of the BCDE-Ring Part of Ciguatoxin

Fujiwara, K., Koyama, Y., Kawai, K., Tanaka, H., and Murai, A.

Synlett   ( 11 ) 1835 - 1838   2002.01  [Refereed]

Research paper (journal)   Domestic Co-author

Chemical realization of the biogenetic pathway proposed for the fused polycyclic ethers of marine origins

Fujiwara, K.

J. Synth. Org. Chem. Jpn.   59 ( 10 ) 948 - 959   2001.01  [Refereed]

Research paper (journal)   Single author

Benzyloxymethyl Group as a Convertible Internal Ligand for La(OTf)3-Catalyzed 7-endo Ring-opening of Hydroxy Epoxide

Fujiwara, K., Morishita, H., Tokiwano, T. and Murai, A.

Heterocycles   54   109 - 110   2001.01  [Refereed]

Research paper (journal)   Domestic Co-author

Convergent Syntheses of the Enantiomeric CD- and JK-Ring Parts of Ciguatoxin

Fujiwara, K., Takaoka, D., Kusumi, K., Kawai, K. and Murai, A.

Synlett     691 - 693   2001.01  [Refereed]

Research paper (journal)   Domestic Co-author

Novel Oxepane Formation by TiCl4-Catalyzed Nucleophilic Cleavage of 1-Alkoxymethyl-6,8-dioxabicyclo[3.2.1]octanes

K. Fujiwara, A. Amano, T. Tokiwano, and A. Murai

Tetrahedron   56 ( 8 ) 1065 - 1080   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Effect of Molecular Sieves and Methanol on the endo-Selectivity in La(OTf)3-catalyzed Cyclization of 5-Hydroxy-2-methoxymethyl-1,2-epoxide System

T. Tokiwano, K. Fujiwara, and A. Murai

Chem. Lett.   ( 3 ) 272 - 273   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Asymmetric Synthesis of the A-ring Part of Ciguatoxin by the Strategy Based on Diastereoselective Hydroboration and Ring Closing Metathesis

K. Fujiwara, H. Tanaka, and A. Murai

Chem. Lett.   ( 6 ) 610 - 611   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stereochemistry in the Bromination of 2,7-Dialkyl-3-hydroxyoxepane System Induced by R3P-Br2 Complex

K. Fujiwara, M. Kobayashi, D. Awakura, and A. Murai

Synlett   ( 8 ) 1187 - 1189   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Biomimetic Construction of Fused Tricyclic Ether by Cascaded endo-Cyclization of the Hydroxy Triepoxide

T. Tokiwano, K. Fujiwara, and A. Murai

Synlett   ( 3 ) 335 - 338   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthetic Studies on Pectenotoxins: Synthesis of the Common C8-C18 THF Fragment

D. Awakura, K. Fujiwara, and A. Murai

Synlett   ( 12 ) 1733 - 1736   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Four-Step Convergent Synthesis of trans-Fused Tetracyclic Oxane

K. Fujiwara, H. Morishita, K. Saka, and A. Murai

Tetrahedron Lett.   41 ( 4 ) 507 - 508   2000.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis of Polycavernoside A

Fujiwara, K. and Murai, A.

J. Synth. Org. Chem. Jpn.   57 ( 11 ) 993 - 1003   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

A Simple Convergent Method for the Construction of Fused Tri- and Tetracyclic Ethers

Fujiwara, K., Saka, K., Takaoka, D. and Murai, A.

Synlett     1037 - 1040   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis of (+)-Obtusenyne

Fujiwara, K., Awakura, D., Tsunashima, M., Nakamura, A., Honma, T. and Murai, A.

J. Org. Chem.   64 ( 8 ) 2616 - 2617   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis and Biological Evaluation of Analogues of the Marine Toxin Polycavernoside A

Barriault, L., Boulet, S. L., Fujiwara, K., Murai, A., Paquette, L. A. and Yotsu-Yamashita, M.

Bioorg. Med. Chem. Lett.   9 ( 14 ) 2069 - 2072   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

Determination of the Absolute Configurations of Norte's Obtusenynes by Total Syntheses of (12R,13R)- (-)- and (12S,13R)-(+)-Obtusenynes

Awakura, D., Fujiwara, K. and Murai, A.

Chem. Lett.   ( 6 ) 461 - 462   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

Chemical Realization of the Biogenetic Pathways Proposed for the Fused-Polycyclic Ethers of Marine Origins

Fujiwara, K., Hayashi, N., Tokiwano, T. and Murai, A.

Heterocycles   50   561 - 593   1999.01  [Refereed]

Research paper (journal)   Domestic Co-author

La(OTf)3-Catalyzed 7-Endo and 8-Endo Selective Cyclizations of Hydroxy Epoxides

Fujiwara, K., Mishima, H., Amano, A., Tokiwano, T., and Murai, A.

Tetrahedron Lett.   39 ( 5-6 ) 393 - 396   1998.01  [Refereed]

Research paper (journal)   Domestic Co-author

Novel Oxepane Formation by Reductive Cleavage of 1-Methoxymethyl-6,8-dioxabicyclo[3.2.1]octanes

Fujiwara, K., Amano, A., Tokiwano, T., and Murai, A.

Heterocycles   47   111 - 112   1998.01  [Refereed]

Research paper (journal)   Domestic Co-author

Total Synthesis and Absolute Configuration of Polycavernoside A

Fujiwara, K., Murai, A., Yotsu-Yamashita, M., and Yasumoto, T.

J. Am. Chem. Soc.   120 ( 41 ) 10770 - 10771   1998.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthetic Studies on Ciguatoxin [2]; Synthesis of the A,B,C-ring System

Oka, T., Fujiwara, K., and Murai, A.

Tetrahedron   54 ( 1-2 ) 21 - 44   1998.01  [Refereed]

Research paper (journal)   Domestic Co-author

The Substituent Effect on Stereoselective Reductive Lithiation of 4,5-Disubstituted 2-Phenylthiooxolane

Amano, S., Fujiwara, K., and Murai, A.

Chem. Lett.   ( 5 ) 409 - 410   1998.01  [Refereed]

Research paper (journal)   Domestic Co-author

The Synthesis of the Common C31-C40 Fragment of Pectenotoxins

Amano, S., Fujiwara, K. and Murai, A.

Synlett   ( 11 ) 1300 - 1302   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

The Biomimetic Construction of Fused Cyclic Polyethers

Hayashi, N., Fujiwara, K. and Murai, A.

Tetrahedron   53 ( 37 ) 12425 - 12468   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

Equilibrium in the Ring Expansion Reaction of the Bromo Epoxides

Hayashi, N., Fujiwara, K. and Murai, A.

Synlett   ( 7 ) 793 - 794   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

The Construction of the A, B, C-ring System of Ciguatoxin

Oka, T., Fujiwara, K. and Murai, A.

Tetrahedron Lett.   38 ( 46 ) 8053 - 8056   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

Diastereoselective Synthesis of the GH Ring Part of Ciguatoxin

Atsuta, H., Fujiwara, K. and Murai, A.

Synlett   ( 3 ) 307 - 309   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of 3-Hydroxy-5-oxonene via 2,3-Epoxy-5-oxonene

Fujiwara, K., Tsunashima, M., Awakura, D. and Murai, A.

Chem. Lett.   ( 7 ) 665 - 666   1997.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of Both Enantiomers of the BC-Ring Part of Ciguatoxin

T. Oka, K. Fujiwara and A. Murai

Tetrahedron   52 ( 37 ) 12091 - 12110   1996.01  [Refereed]

Research paper (journal)   Domestic Co-author

AgOTf-Promoted Conversion of 4,5-Epoxy-1-bromide into Tetrahydropyran Ring

N. Hayashi, K. Fujiwara and A. Murai

Chem. Lett.   ( 5 ) 341 - 342   1996.01  [Refereed]

Research paper (journal)   Domestic Co-author

Fused Cyclic Ether Formations from Bromo-Diepoxides by AgOTf- Promoted Successive Ring Expansion Reactions

N. Hayashi, K. Fujiwara and A. Murai

Tetrahedron Lett.   37 ( 34 ) 6173 - 6176   1996.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis and relative configuration of the sugar part of a marine toxin polycavernoside-A

K. Fujiwara, S. Amano, and A. Murai

Chem. Lett.   ( 3 ) 191 - 192   1995.01  [Refereed]

Research paper (journal)   Domestic Co-author

Relative configuration of a marine toxin polycavernoside-A

K. Fujiwara, S. Amano, and A. Murai

Chem. Lett.   ( 9 ) 855 - 856   1995.01  [Refereed]

Research paper (journal)   Domestic Co-author

Stereoselective synthesis of Δ5-oxonene and its novel ring contraction to Δ4-oxocene.

K. Fujiwara, M. Tsunashima, D. Awakura, and A. Murai

Tetrahedron Lett.   36 ( 45 ) 8263 - 8266   1995.01  [Refereed]

Research paper (journal)   Domestic Co-author

La(OTf)3-catalyzed 6-endo epoxide opening of 4,5-epoxy-4-methoxymethyl-1-hexanols

K. Fujiwara, T. Tokiwano, and A. Murai

Tetrahedron Lett.   36 ( 44 ) 8063 - 8066   1995.01  [Refereed]

Research paper (journal)   Domestic Co-author

Reactions of neocarzinostatin chromophore analogs with molecular oxygen

K. Fujiwara, H. Sakai, T. Tanaka, and M. Hirama

Chem. Lett.   ( 3 ) 457 - 460   1994.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the tetrahydrofuran ring part of a marine toxin polycavernoside-A

N. Hayashi, T. Mine, K. Fujiwara, and A. Murai

Chem. Lett.   ( 11 ) 2143 - 2146   1994.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of the tetrahydropyran ring part of a marine toxin polycavernoside-A

K. Fujiwara, S. Amano, T. Oka, and A. Murai

Chem. Lett.   ( 11 ) 2147 - 2150   1994.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis of a hybrid molecule containing neocarzinostatin chromophore analog and minor groove binder

M. Tokuda, K. Fujiwara, T. Gomibuchi, M. Hirama, M. Uesugi, and Y. Sugiura

Tetrahedron Lett.   34 ( 4 ) 669 - 672   1993.01  [Refereed]

Research paper (journal)   Domestic Co-author

Origin of photo-lability of neocarzinostatin chromophore

T. Gomibuchi, K. Fujiwara, T. Nehira, and M. Hirama

Tetrahedron Lett.   34 ( 36 ) 5753 - 5756   1993.01  [Refereed]

Research paper (journal)   Domestic Co-author

Site-specific generation of nonstabilized α-amino carbanions a novel methodology toward the synthesis of 2-amino alcohols

T. Tsunoda, K. Fujiwara, Y. Yamamoto, and S. Ito

Tetrahedron Lett.   32 ( 17 ) 1975 - 1978   1991.01  [Refereed]

Research paper (journal)   Domestic Co-author

Enyne[3]cumulene. Synthesis and mode of aromatization

K. Fujiwara, H. Sakai, and M. Hirama

J. Org. Chem.   56 ( 5 ) 1688 - 1689   1991.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis and DNA cleaving abilities of functional neocarzinostatin chromophore analogs. Base discrimination by a simple alcohol

M. Hirama, T. Gomibuchi, K. Fujiwara, Y. Sugiura, and M. Uesugi

J. Am. Chem. Soc.   113 ( 26 ) 9851 - 9853   1991.01  [Refereed]

Research paper (journal)   Domestic Co-author

Synthesis and cycloaromatization of a neocarzinostatin chromophore analog equipped with an intramolecular nucleophile.

M. Hirama, M. Tokuda, and K. Fujiwara

Synlett   ( 9 ) 651 - 653   1991.01  [Refereed]

Research paper (journal)   Domestic Co-author

Two diverse modes of aromatization of a new 10-membered ring analog of neocarzinostatin chromophore

K. Fujiwara, A. Kurisaki, and M. Hirama

Tetrahedron Lett.   31 ( 30 ) 4329 - 4332   1990.01  [Refereed]

Research paper (journal)   Domestic Co-author

Oxidative triggering for aromatization of the neocarzinostatin chromophore

T. Tanaka, K. Fujiwara, and M. Hirama

Tetrahedron Lett.   31 ( 41 ) 5947 - 5950   1990.01  [Refereed]

Research paper (journal)   Domestic Co-author

The 10-membered ring analogs of neocarzinostatin chromophore: design, synthesis and mode of decomposition

M. Hirama, K. Fujiwara, K. Shigematu, and Y. Fukazawa

J. Am. Chem. Soc.   111 ( 11 ) 4120 - 4122   1989.01  [Refereed]

Research paper (journal)   Domestic Co-author

Baeyer-Villiger oxidation of β-ionone with surfactant-type peracid

Y. Fujise, K. Fujiwara, and Y. Ito

Chem. Lett.   ( 9 ) 1475 - 1476   1988.01  [Refereed]

Research paper (journal)   Domestic Co-author