MATSUMURA Hirotoshi

写真a

Affiliation

Graduate School of Engineering Science  Department of Life Science  Life Science Course 

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Research Interests 【 display / non-display 】

  • Bioinorganic chemistry Vibrational spectroscopy

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Graduating School 【 display / non-display 】

  • 　
    -
    2003.03

    Tokyo University of Agriculture and Technology   Faculty of Engineering Science   Graduated

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Graduate School 【 display / non-display 】

  • 　
    -
    2008.03

    Tokyo University of Agriculture and Technology  Graduate School,Division of Engineering  Doctor's Course  Completed

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Campus Career 【 display / non-display 】

  • 2021.04
    -
    Now

    Akita University   Graduate School of Engineering Science   Department of Life Science   Life Science Course   Associate Professor  

  • 2015.04
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    2021.03

    Akita University   Abolished organization   Department of Life Science   Lecturer  

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Thesis for a degree 【 display / non-display 】

  • Artificial Electron Donors Supported Enzymatic Reaction of Thermophilic Cytochrome P450 from Sulfolobus tokodaii strain 7

    Matsumura, H. 

      2008.03

    Single author

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Research Achievements 【 display / non-display 】

    ◆Original paper【 display / non-display 】

  • Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis

    Kaga, H., Matsumura, H., Saito, A., Saito, M., Abe, Fumito., Suzuki, T., Dohmae, N., Odaka, M., Komatsuda, A., Wakui, H., Takahashi, N.

    Clinical Proteomics   20 ( 21 )   2023.05  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy

    Kaga, H., Matsumura, H., Suzuki, T., Dohmae, N., Odaka, M., Komatsuda, A., Takahashi, N., Wakui, H.

    Clinical Proteomics ( Clinical Proteomics )  19 ( 1 )   2022.07  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Mechanism of substrate inhibition in cytochrome-c dependent NO reductases from denitrifying bacteria (cNORs)

    Matsumura, H., Faponle, A.S., Hagedoorn, P.-L., Tosha, T., de Visser, S.P., Moënne-Loccoz, P.

    J. Inorg. Biochem.   231   111781   2022.03  [Refereed]

    Research paper (journal)   International Co-author

  • Multiple Myeloma–Associated Ig Light Chain Crystalline Cast Nephropathy

    Matsumura H., Furukawa, Y., Nakagaki, T., Furutani, C., Osanai, S., Noguchi, K., Odaka, M., Yohda, M., Ohtani, H., Michishita, Y., Kawabata, Y., Kitabayashi, A., Ikeda, S., Nara, M., Komatsuda, A., Takahashi, N., Wakui, H.

    Kidney International Reports ( International Society of Nephrology )  5 ( 9 ) 1595 - 1602   2020.09  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Comparative proteomic analysis of renal proteins from IgA nephropathy model mice and control mice

    Miyakawa, R., Sato, A., Matsuda, Y., Saito, A., Abe, F., Matsumura, H., Odaka, M., Suzuki, T., Dohmae, N., Komatsuda, A., Takahashi, N., Wakui, H.

    Clinical and Experimental Nephrology ( Springer Nature )  24 ( 8 ) 666 - 679   2020.08  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

    • display all >>

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    ◆Introduction and explanation【 display / non-display 】

  • Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary activity family in the database of carbohydrate-active enzymes

      ( 75 ) 24 - 30   2016.04

    Introduction and explanation (others)   Domestic Co-author

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    ◆Other【 display / non-display 】

  • Antitumor effects of a novel antibody-drug conjugate (ADC) targeting intracellular iron metabolism and porphyrin biosynthesis pathways on colorectal cancer cell lines

    ITO Reina, SASAKI Katsuya, KUMAGAI Maho, EZAWA Toshinori, MATSUMURA Hirotoshi, ITOH Fumie, TANAKA Yutaka, SASAKI Masato, KIKUCHI Masafumi

    Annual Meeting of the Japanese Society of Toxicology ( The Japanese Society of Toxicology )  52.1 ( 0 ) P-185   2025

    <p>Antibody-drug conjugates (ADCs), which covalently link therapeutic antibodies with specific compounds, are gaining attention for their potential to enhance tumor treatment while reducing adverse effects. ADCs not only retain the antitumor properties of the therapeutic antibody but also allow efficient delivery of the conjugated compounds to cancer cells. 12 ADCs have been approved in Japan, including compounds such as microtubule inhibitors, DNA double-strand break inducers, topoisomerase inhibitors, radioisotopes, and photoimmunotherapy agents. ADCs are expected to provide new therapeutic options by modifying binding molecules, though their development is still ongoing.To create a new ADC, we generated cetuximab-deferoxamine (CTX-DFO), which targets metabolism in cancer stem cells. Cancer stem cells are known to be highly Fe-dependent, with Fe incorporated into protoporphyrin IX (PpIX) to produce heme. As Fe is removed from these cells, PpIX accumulates. When exposed to blue light, PpIX emits fluorescence, generating reactive oxygen species (ROS), which can induce cell death. This accumulation of PpIX and exposure to blue light may be effective in killing cancer cells. Although DFO is predicted to enhance cell death by accumulating PpIX, it does not specifically target cancer cells. Our CTX-DFO aims to selectively deliver DFO to EGFR-expressing cells, the target of CTX, and exert its effect in a more targeted manner. CTX is used for KRAS wild-type colon cancer, and we will evaluate the efficacy of CTX-DFO using HT29 cells, a colon cancer cell line with the same genotype.</p>

    DOI CiNii Research

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Books 【 display / non-display 】

  • HAPTER 16: Mechanisms of Nitric Oxide Sensing and Detoxification by Bacterial Hemoproteins in Dioxygen-dependent Heme Enzymes, Metallobiology Series No. 13

    Moënne-Loccoz, P., Yukl, E., Matsumura, H.

    The Royal Society of Chemistry  2018.10 ISBN: 978-1-78262-991-7

  • HAPTER 8: Characterizing Millisecond Intermediates in Metalloproteins: Methods and Protocols, Methods in Molecular Biology

    Matsumura, H., Moënne-Loccoz, P.

    Springer Nature  2014.02 ISBN: 978-1-62703-794-5

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(B)

    Project Year： 2019.04  -  2022.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2019.04  -  2022.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2018.04  -  2021.03 

  • Investigating extracellular redox network in the rice blast fungus Magnaporthe oryzae

    Grant-in-Aid for Young Scientists(B)

    Project Year： 2017.04  -  2019.03 

  • Expression and characterization of cellobiose dehydrogenases from the ascomycete fungus, Magnaporthe oryzae for management of the rice blast disease

    Grant-in-Aid for Research Activity start-up

    Project Year： 2015.08  -  2017.03 

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Presentations 【 display / non-display 】

  • 抗リウマチ薬メトトレキサートとマクロファージ遊走阻害因子の相互作用解析

    松村 洋寿，杉島 小雪，面川 歩，長門石 曉，津本 浩平，重田 育照，尾高 雅文，廣川 誠，涌井 秀樹

    第14回バイオ関連化学シンポジウム  2020.09  -  2020.09 

  • Mechanistic studies of iron acquisition by the hemophore HasA from Gram negative pathogens

    Matsumura, H., Rivera, M., and Moënne-Loccoz, P.  [Invited]

    The 43rd International Conference on Coordination Chemistry (ICCC2018)  (Sendai, Japan)  2018.07  -  2018.08 

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Academic Activity 【 display / non-display 】

  • 2023.04
    　
    　

  • 2020.04
    -
    2021.03

  • 2019.04
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    Now

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