SATO Teruki

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Organ Function-Oriented Medicine  Department of Cardiovascular Medicine
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Research Interests 【 display / non-display 】

  • Cardiovascular medicine

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Graduating School 【 display / non-display 】

  • 　
    -
    2006.03

    Akita University   Faculty of Medicine   Graduated

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Graduate School 【 display / non-display 】

  • 　
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    2014.03

    Akita University  Graduate School, Division of Medicine  Doctor's Course  Completed

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Campus Career 【 display / non-display 】

  • 2024.06
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Department of Cardiovascular Medicine   Lecturer  

  • 2021.10
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    2024.05

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Department of Cardiovascular Medicine   Assistant Professor  

  • 2015.04
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    2020.02

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Public Health and Environmental Medicine   Specially-appointed Assistant Professor  

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Thesis for a degree 【 display / non-display 】

  • Apelin is a positive regulator of ACE2 in failing hearts

    Teruki Sato, Takashi Suzuki, Hiroyuki Watanabe, Ayumi Kadowaki, Akiyoshi Fukamizu, Peter P Liu, Akinori Kimura, Hiroshi Ito, Josef M Penninger, Yumiko Imai, Keiji Kuba 

    The Journal of Clinical Investigation  123 ( 12 ) 5203 - 5211   2014.03  [Refereed]

    Single author

    DOI

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Research Achievements 【 display / non-display 】

    ◆Other【 display / non-display 】

  • The functional role of endogenous APJ agonists; Apelin and Elabela/Toddler in cardiovascular diseases

    Sato Teruki, Kuba Keiji

    Folia Pharmacologica Japonica ( The Japanese Pharmacological Society )  153 ( 4 ) 172 - 178   2019

    <p>Apelin is an endogenous peptide ligand for APJ receptor, which is widely expressed in human body, and exerts various physiological effects such as vasodilation, inotropic effect, water balance, heart development, angiogenesis and energy metabolism. The beneficial effects of Apelin in cardiovascular diseases have been elucidated, and the roles of Apelin in aging-associated diseases are recently implicated. The mechanisms for therapeutic effects of Aplein include an antagonistic action to renin-angiotensin system (RAS) in addition to inotropic and vasodilatory actions. We have revealed that endogenous Apelin negatively regulates RAS via upregulation of Angiotensin converting enzyme 2 (ACE2). In addition, a second ligand for APJ receptor, Elabela/Toddler, was identified as an essential hormone for heart development, and it has been reported to have physiological effects similar to Apelin. We and others have shown that Elabela exerts inotropic and protective effects in the heart. Although the number of heart failure patients is rapidly increasing, the pathophysiology of heart failure remains elusive and further development of new therapeutic option is awaited. Apelin is a unique bifunctional molecule, which has both inotropic and cardioprotective effects in heart failure, and thus further elucidation of the mechanisms for Apelin/Elabela-APJ signaling would contribute to development of a novel therapeutics for heart failure patients.</p>

    DOI

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