SHIMIZU Hiroaki

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Organ Function-Oriented Medicine  Department of Neurosurgery

Laboratory Address

1-1-1 Hondo Akita-city AKITA, JAPAN

Research Interests 【 display / non-display

  • Neurosurgery

  • Stroke

  • Cerebrovascular disease

  • Neurosurgery

Graduating School 【 display / non-display

  •  
    -
    1986.03

    Tohoku University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display

  •  
    -
    1992.03

    Tohoku University  Graduate School,Division of Medicine  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2014.04
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Professor  

Academic Society Affiliations 【 display / non-display

  • 1991.04
    -
    Now
     

    Japan

     

    Japanese Society on Surgery for cerebral Stroke

  • 1991.04
    -
    Now
     

    Japan

     

    Japan Stroke Society

Research Areas 【 display / non-display

  • Life Science / Neurosurgery

  • Life Science / Neurosurgery  / Cerebrovascular disease

Qualification acquired 【 display / non-display

  • Doctor

 

Thesis for a degree 【 display / non-display

  • ラット全脳虚血モデルにおける脳内神経伝達アミノ 酸とエネルギー代謝の動態及び相関に関する研究

    H Shimizu, S H Graham, L H Chang, J Mintorovitch, T L James, A I Faden, P R Weinstein 

    Brain Research  605 ( 1 ) 33 - 42   1992.03  [Refereed]

    International Co-author

    DOI

Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • Detailed molecular and pathological analyses of primary intracranial embryonal rhabdomyosarcoma with a BRAF mutation: illustrative case.

    Masamichi Abe, Takahiro Ono, Felix Hinz, Masataka Takahashi, Yuko Hiroshima, Koya Kodama, Michihiro Yano, Hiroshi Nanjo, Tsutomu Takahashi, Andreas von Deimling, Hiroaki Shimizu

    Journal of neurosurgery. Case lessons ( Journal of Neurosurgery: Case Lessons )  6 ( 1 )   2023.07  [Refereed]

    Research paper (journal)   International Co-author

    BACKGROUND: The etiological significance of the RAS and PI3K pathways has been reported in systemic embryonal rhabdomyosarcoma (ERMS) but not in primary intracranial ERMS (PIERMS). Herein, the authors present a unique case of PIERMS with a BRAF mutation. OBSERVATIONS: A 12-year-old girl with progressive headache and nausea was diagnosed with a tumor in the right parietal lobe. Semi-emergency surgery revealed an intra-axial lesion that was histopathologically identical to an ERMS. Next-generation sequencing indicated a BRAF mutation as a pathogenic variation, but the RAS and PI3K pathways showed no alteration. Although there is no established reference class for PIERMS, the DNA methylation prediction was closest to that of ERMS, indicating the possibility of PIERMS. The final diagnosis was PIERMS. The patient underwent local radiotherapy (50.4 Gy) and multiagent chemotherapy, with no recurrence for 12 months after surgery. LESSONS: This may be the first case demonstrating the molecular features of PIERMS, especially the intra-axial type. The results showed a mutation in BRAF but not in the RAS and PI3K pathways, which is different from the existing ERMS features. This molecular difference may cause differences in DNA methylation profiles. Accumulation of the molecular features of PIERMS is necessary before any conclusions can be drawn.

    DOI PubMed

  • Outcomes of initial conservative management in patients with acute subdural hematoma

    Kuwayama Mikiko, Ono Takahiro, Togashi Shuntaro, Takahashi Masataka, Shimizu Hiroaki

    Neurotraumatology ( The Japan Society of Neurotraumatology )  46 ( 1 ) 12 - 19   2023.06  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI Repository CiNii Research

  • National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study

    Ryota Kurogi, Akiko Kada, Kuniaki Ogasawara, Kunihiro Nishimura, Takanari Kitazono, Toru Iwama, Yuji Matsumaru, Nobuyuki Sakai, Yoshiaki Shiokawa, Shigeru Miyachi, Satoshi Kuroda, Hiroaki Shimizu, Shinichi Yoshimura, Toshiaki Osato, Nobutaka Horie, Izumi Nagata, Kazuhiko Nozaki, Isao Date, Yoichiro Hashimoto, Haruhiko Hoshino, Hiroyuki Nakase, Hiroharu Kataoka, Tsuyoshi Ohta, Hitoshi Fukuda, Nanako Tamiya, A I Kurogi, Nice Ren, Ataru Nishimura, Koichi Arimura, Takafumi Shimogawa, Koji Yoshimoto, Daisuke Onozuka, Soshiro Ogata, Akihito Hagihara, Nobuhito Saito, Hajime Arai, Susumu Miyamoto, Teiji Tominaga, Koji Iihara; J-ASPECT Study Collaborators

    BMJ open ( BMJ open )  13 ( 4 )   2023.04  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Pathological and molecular findings of astrocytoma that showed malignant transformation in 12 years : a case report

      49 ( 3/4 ) 131 - 138   2023.03  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI CiNii Research

  • Current Treatment Results of Intracranial Carotid Artery Dissection Causing Cerebral Ischemia: A Japanese Nationwide Survey.

    Hiroaki Shimizu, Takahiro Ono, Takatsugu Abe, Masaaki Hokari, Yusuke Egashira, Koji Shimonaga, Masahiko Kawanishi, Kyoko Nomura, Yusuke Takahashi

    Neurologia medico-chirurgica ( Neurologia Medico-Chirurgica )  63 ( 2 ) 80 - 89   2023.01  [Refereed]

    Research paper (journal)   Domestic Co-author

    Intracranial carotid artery dissection causing cerebral ischemia is a rare but important cause of cerebral infarction in children and adolescents. Although endovascular therapy has been reported to be effective, questions regarding the indications for intervention are yet to be addressed. Therefore, this study aimed to evaluate factors related to clinical outcomes through a nationwide survey. Overall, 35 neurosurgical centers reported patients within 2 weeks after ischemic onset due to intracranial carotid artery dissection causing cerebral ischemia treated between January 2015 and December 2020. Data on clinical and radiological findings were statistically analyzed. Twenty-eight patients met the inclusion criteria. The median age was 36 years (range, 7-59 years), without sex differences. Headache at onset was documented in 60.7% of the patients. Dissection findings were categorized into stenosis (71.4%) or occlusion (28.6%). Initial treatments, including various antithrombotic agent combinations in 23 (82.1%) patients, effectively improved or prevented aggravation in half of the patients. The patients with stenotic dissection were significantly more likely to experience aggravation during the initial treatment than did those with occlusive dissection (P = 0.03). In addition, the patients with moderate to severe neurological deficits on admission had poorer outcomes at discharge more frequently than did those with mild neurological deficits on admission. Eight patients undergoing endovascular therapy had no procedural complications or further aggravation after intervention. In conclusion, patients with intracranial carotid dissection causing cerebral ischemia who had a stenotic dissection were at risk of further aggravation, and endovascular therapy effectively improved or prevented aggravation.

    DOI Repository PubMed

  • display all >>

    ◆Introduction and explanation【 display / non-display

  • Complex Intracranial Aneurysms.

    Shuntaro Togashi, Hiroaki Shimizu

    Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery )  44   225 - 238   2022

    Introduction and explanation (commerce magazine)   Domestic Co-author

    Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.

    DOI PubMed

  • ◆Research society, Symposium materials, etc.【 display / non-display

  • Evaluation method of hardness of vessel using balloon catheter

    ITO Yuta, NAGANAWA Akihiro, KOMATSU Kazumi, SEKI Takeshi, HIRASAWA Fujiko, TAKAHASHI Masataka, SHIMIZU Hiroaki

    The Proceedings of Autumn Conference of Tohoku Branch ( The Japan Society of Mechanical Engineers )  2018 ( 0 )   2018

    Research paper (research society, symposium materials, etc.)   Domestic Co-author

    DOI

  • ◆Other【 display / non-display

  • Complex Intracranial Aneurysms

    Togashi S、Shimizu H.

    Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery )  44   225 - 238   2022  [Invited]

    Domestic Co-author

    Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.

    DOI PubMed

  • The REAL-WORLD of Elderly PCNSL Therapy in Tohoku and Niigata Area According to Retrospective Analysis: A Collaborative Investigation of the Tohoku Brain Tumor Study Group

    浅野研一郎, 山下洋二, 小野隆裕, 棗田学, 別府高明, 松田憲一朗, 市川優寛, 金森政之, 松坂方士, 黒瀬顕, 齋藤清, 園田順彦, 小笠原邦昭, 藤井幸彦, 清水宏明, 大熊洋揮, 北中千史, 嘉山孝正, 冨永悌二

    日本脳腫瘍学会プログラム・抄録集   38th   2020

    J-GLOBAL

  • Screening of cervical spine diseases by T1 fast spin echo reconstruction images obtained from routine head MRI

    鈴木隼士, 鈴木隼士, 山口卓, 千葉大志, 菅原卓, 清水宏明

    日本脊髄外科学会プログラム・抄録集   35th (CD-ROM)   2020

    Summary of the papers read (national conference and other science council)   Domestic Co-author

    J-GLOBAL

  • REBIRTH as the Activity of the Japanese Society for Neuroendovascular Therapy Tohoku Branch Association

    國分康平, 清水宏明, 松本康史

    脳血管内治療(Web)   4 ( 1 )   2019

    J-GLOBAL

Grant-in-Aid for Scientific Research 【 display / non-display

  • Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2025.03 

  • Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2025.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2021.03 

  • Development of a new experimental model of chronic cerebral ischemia with vascular endothelial impairment and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2021.03  Investigator(s): Shimizu Hiroaki

  • Multidisciplinary Approach for Arteriovenous Malformation Based on Computational Fluid Dynamics

    Grant-in-Aid for Scientific Research(B)

    Project Year: 2014.04  -  2017.03  Investigator(s): Shimizu Hiroaki

display all >>

 

Academic Activity 【 display / non-display

  • 2021.10
    -
    Now

  • Japanese Society on Surgery for cerebral Stroke

    2019.04
    -
    Now

  • Japan Stroke Society

    2014.04
    -
    Now

  • 2014.04
    -
    Now

  • 2010.04
    -
    Now

display all >>