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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Neurosurgery |
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Laboratory Address |
1-1-1 Hondo Akita-city AKITA, JAPAN |
SHIMIZU Hiroaki
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Research Interests 【 display / non-display 】
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Neurosurgery
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Stroke
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Cerebrovascular disease
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Neurosurgery
Graduating School 【 display / non-display 】
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-1986.03
Tohoku University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-1992.03
Tohoku University Graduate School,Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2014.04-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Professor
Academic Society Affiliations 【 display / non-display 】
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1991.04-Now
Japan
Japanese Society on Surgery for cerebral Stroke
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1991.04-Now
Japan
Japan Stroke Society
Research Areas 【 display / non-display 】
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Life Science / Neurosurgery
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Life Science / Neurosurgery / Cerebrovascular disease
Thesis for a degree 【 display / non-display 】
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ラット全脳虚血モデルにおける脳内神経伝達アミノ 酸とエネルギー代謝の動態及び相関に関する研究
H Shimizu, S H Graham, L H Chang, J Mintorovitch, T L James, A I Faden, P R Weinstein
Brain Research 605 ( 1 ) 33 - 42 1992.03 [Refereed]
International Co-author
Research Achievements 【 display / non-display 】
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Masamichi Abe, Takahiro Ono, Felix Hinz, Masataka Takahashi, Yuko Hiroshima, Koya Kodama, Michihiro Yano, Hiroshi Nanjo, Tsutomu Takahashi, Andreas von Deimling, Hiroaki Shimizu
Journal of neurosurgery. Case lessons ( Journal of Neurosurgery: Case Lessons ) 6 ( 1 ) 2023.07 [Refereed]
Research paper (journal) International Co-author
BACKGROUND: The etiological significance of the RAS and PI3K pathways has been reported in systemic embryonal rhabdomyosarcoma (ERMS) but not in primary intracranial ERMS (PIERMS). Herein, the authors present a unique case of PIERMS with a BRAF mutation. OBSERVATIONS: A 12-year-old girl with progressive headache and nausea was diagnosed with a tumor in the right parietal lobe. Semi-emergency surgery revealed an intra-axial lesion that was histopathologically identical to an ERMS. Next-generation sequencing indicated a BRAF mutation as a pathogenic variation, but the RAS and PI3K pathways showed no alteration. Although there is no established reference class for PIERMS, the DNA methylation prediction was closest to that of ERMS, indicating the possibility of PIERMS. The final diagnosis was PIERMS. The patient underwent local radiotherapy (50.4 Gy) and multiagent chemotherapy, with no recurrence for 12 months after surgery. LESSONS: This may be the first case demonstrating the molecular features of PIERMS, especially the intra-axial type. The results showed a mutation in BRAF but not in the RAS and PI3K pathways, which is different from the existing ERMS features. This molecular difference may cause differences in DNA methylation profiles. Accumulation of the molecular features of PIERMS is necessary before any conclusions can be drawn.
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Outcomes of initial conservative management in patients with acute subdural hematoma
Kuwayama Mikiko, Ono Takahiro, Togashi Shuntaro, Takahashi Masataka, Shimizu Hiroaki
Neurotraumatology ( The Japan Society of Neurotraumatology ) 46 ( 1 ) 12 - 19 2023.06 [Refereed]
Research paper (journal) Domestic Co-author
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Ryota Kurogi, Akiko Kada, Kuniaki Ogasawara, Kunihiro Nishimura, Takanari Kitazono, Toru Iwama, Yuji Matsumaru, Nobuyuki Sakai, Yoshiaki Shiokawa, Shigeru Miyachi, Satoshi Kuroda, Hiroaki Shimizu, Shinichi Yoshimura, Toshiaki Osato, Nobutaka Horie, Izumi Nagata, Kazuhiko Nozaki, Isao Date, Yoichiro Hashimoto, Haruhiko Hoshino, Hiroyuki Nakase, Hiroharu Kataoka, Tsuyoshi Ohta, Hitoshi Fukuda, Nanako Tamiya, A I Kurogi, Nice Ren, Ataru Nishimura, Koichi Arimura, Takafumi Shimogawa, Koji Yoshimoto, Daisuke Onozuka, Soshiro Ogata, Akihito Hagihara, Nobuhito Saito, Hajime Arai, Susumu Miyamoto, Teiji Tominaga, Koji Iihara; J-ASPECT Study Collaborators
BMJ open ( BMJ open ) 13 ( 4 ) 2023.04 [Refereed]
Research paper (journal) Domestic Co-author
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49 ( 3/4 ) 131 - 138 2023.03 [Refereed]
Research paper (journal) Domestic Co-author
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Hiroaki Shimizu, Takahiro Ono, Takatsugu Abe, Masaaki Hokari, Yusuke Egashira, Koji Shimonaga, Masahiko Kawanishi, Kyoko Nomura, Yusuke Takahashi
Neurologia medico-chirurgica ( Neurologia Medico-Chirurgica ) 63 ( 2 ) 80 - 89 2023.01 [Refereed]
Research paper (journal) Domestic Co-author
Intracranial carotid artery dissection causing cerebral ischemia is a rare but important cause of cerebral infarction in children and adolescents. Although endovascular therapy has been reported to be effective, questions regarding the indications for intervention are yet to be addressed. Therefore, this study aimed to evaluate factors related to clinical outcomes through a nationwide survey. Overall, 35 neurosurgical centers reported patients within 2 weeks after ischemic onset due to intracranial carotid artery dissection causing cerebral ischemia treated between January 2015 and December 2020. Data on clinical and radiological findings were statistically analyzed. Twenty-eight patients met the inclusion criteria. The median age was 36 years (range, 7-59 years), without sex differences. Headache at onset was documented in 60.7% of the patients. Dissection findings were categorized into stenosis (71.4%) or occlusion (28.6%). Initial treatments, including various antithrombotic agent combinations in 23 (82.1%) patients, effectively improved or prevented aggravation in half of the patients. The patients with stenotic dissection were significantly more likely to experience aggravation during the initial treatment than did those with occlusive dissection (P = 0.03). In addition, the patients with moderate to severe neurological deficits on admission had poorer outcomes at discharge more frequently than did those with mild neurological deficits on admission. Eight patients undergoing endovascular therapy had no procedural complications or further aggravation after intervention. In conclusion, patients with intracranial carotid dissection causing cerebral ischemia who had a stenotic dissection were at risk of further aggravation, and endovascular therapy effectively improved or prevented aggravation.
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Complex Intracranial Aneurysms.
Shuntaro Togashi, Hiroaki Shimizu
Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery ) 44 225 - 238 2022
Introduction and explanation (commerce magazine) Domestic Co-author
Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.
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Evaluation method of hardness of vessel using balloon catheter
ITO Yuta, NAGANAWA Akihiro, KOMATSU Kazumi, SEKI Takeshi, HIRASAWA Fujiko, TAKAHASHI Masataka, SHIMIZU Hiroaki
The Proceedings of Autumn Conference of Tohoku Branch ( The Japan Society of Mechanical Engineers ) 2018 ( 0 ) 2018
Research paper (research society, symposium materials, etc.) Domestic Co-author
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Complex Intracranial Aneurysms
Togashi S、Shimizu H.
Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery ) 44 225 - 238 2022 [Invited]
Domestic Co-author
Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.
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The REAL-WORLD of Elderly PCNSL Therapy in Tohoku and Niigata Area According to Retrospective Analysis: A Collaborative Investigation of the Tohoku Brain Tumor Study Group
浅野研一郎, 山下洋二, 小野隆裕, 棗田学, 別府高明, 松田憲一朗, 市川優寛, 金森政之, 松坂方士, 黒瀬顕, 齋藤清, 園田順彦, 小笠原邦昭, 藤井幸彦, 清水宏明, 大熊洋揮, 北中千史, 嘉山孝正, 冨永悌二
日本脳腫瘍学会プログラム・抄録集 38th 2020
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Screening of cervical spine diseases by T1 fast spin echo reconstruction images obtained from routine head MRI
鈴木隼士, 鈴木隼士, 山口卓, 千葉大志, 菅原卓, 清水宏明
日本脊髄外科学会プログラム・抄録集 35th (CD-ROM) 2020
Summary of the papers read (national conference and other science council) Domestic Co-author
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REBIRTH as the Activity of the Japanese Society for Neuroendovascular Therapy Tohoku Branch Association
國分康平, 清水宏明, 松本康史
脳血管内治療(Web) 4 ( 1 ) 2019
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Research society, Symposium materials, etc.【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction
Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03
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Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction
Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2018.04 - 2021.03
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Development of a new experimental model of chronic cerebral ischemia with vascular endothelial impairment and elucidation of hyperperfusion following vascular reconstruction
Grant-in-Aid for Scientific Research(C)
Project Year： 2018.04 - 2021.03 Investigator(s): Shimizu Hiroaki
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Multidisciplinary Approach for Arteriovenous Malformation Based on Computational Fluid Dynamics
Grant-in-Aid for Scientific Research(B)
Project Year： 2014.04 - 2017.03 Investigator(s): Shimizu Hiroaki
Academic Activity 【 display / non-display 】
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2021.10-Now
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Japanese Society on Surgery for cerebral Stroke
2019.04-Now -
Japan Stroke Society
2014.04-Now -
2014.04-Now
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2010.04-Now