SHIMIZU Hiroaki

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Organ Function-Oriented Medicine  Department of Neurosurgery

Laboratory Address

1-1-1 Hondo Akita-city AKITA, JAPAN
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Research Interests 【 display / non-display 】

  • Neurosurgery

  • Stroke

  • Cerebrovascular disease

  • Neurosurgery

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Graduating School 【 display / non-display 】

  • 　
    -
    1986.03

    Tohoku University   Faculty of Medicine   Graduated

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Graduate School 【 display / non-display 】

  • 　
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    1992.03

    Tohoku University  Graduate School,Division of Medicine  Doctor's Course  Completed

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Campus Career 【 display / non-display 】

  • 2014.04
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Professor  

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Academic Society Affiliations 【 display / non-display 】

  • 1991.04
    -
    Now
     

    Japan

     

    Japanese Society on Surgery for cerebral Stroke

  • 1991.04
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    Now
     

    Japan

     

    Japan Stroke Society

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Research Areas 【 display / non-display 】

  • Life Science / Neurosurgery

  • Life Science / Neurosurgery  / Cerebrovascular disease

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Qualification acquired 【 display / non-display 】

  • Doctor

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Thesis for a degree 【 display / non-display 】

  • ラット全脳虚血モデルにおける脳内神経伝達アミノ 酸とエネルギー代謝の動態及び相関に関する研究

    H Shimizu, S H Graham, L H Chang, J Mintorovitch, T L James, A I Faden, P R Weinstein 

    Brain Research  605 ( 1 ) 33 - 42   1992.03  [Refereed]

    International Co-author

    DOI

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Research Achievements 【 display / non-display 】

    ◆Original paper【 display / non-display 】

  • Identifying the appropriate measurement environment for laser speckle flowmetry of cerebral blood flow in rats

    Ryosei Wakasa, Takahiro Ono, Naomoto Senbokuya, Mikiko Kuwayama, Hiroaki Shimizu

    Brain Research ( Elsevier BV )  1850   149443 - 149443   2025.01  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Mizoribine Promotes Molecular Chaperone HSP60/HSP10 Complex Formation

    Miura A.

    International Journal of Molecular Sciences ( International Journal of Molecular Sciences )  25 ( 12 )   2024.06  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • The components of the AhR-molecular chaperone complex differ depending on whether the ligands are toxic or non-toxic

    Narita Y.

    FEBS Letters ( FEBS Letters )  598 ( 12 ) 1478 - 1490   2024.06  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Clinical Course after Carmustine Wafer Implantation for Newly Diagnosed Adult-type Diffuse Gliomas; A controlled propensity matched analysis of a single center cohort.

    Takahiro Ono, Hayato Suzuki, Hiroshi Nanjo, Hiroaki Shimizu

    Journal of neuro-oncology ( Journal of Neuro-Oncology )  168 ( 3 ) 393 - 404   2024.05  [Refereed]

    Research paper (journal)   Domestic Co-author

    PURPOSE: It remains unclear whether combining carmustine wafer (CW) implantation with the standard treatment for adult-type diffuse gliomas is safe and has a prognostic impact. This study aimed to investigate the prognostic value and safety of CW implantation. METHODS: Adult patients with IDH-wild-type and -mutant gliomas, grades 3-4 treated with surgical resection, radiotherapy, and temozolomide chemotherapy between 2013 and 2023 were surveyed. CWs were implanted except in cases of intraoperative wide ventricle opening or marked preoperative brain swelling. For survival analyses, a case-matched dataset based on propensity score matching (PSM), including multiple factors (patient background, diagnosis, and extent of resection) was generated. Progression-free survival (PFS), overall survival (OS), and frequency of complications of CW implantation (brain edema, infection, and cerebrospinal fluid leakage) were compared between the CW and non-use groups. RESULTS: In total, 127 patients (75 in the CW use group and 52 in the non-use group) were enrolled. Regardless of stratification, no significant differences in PFS and OS were observed between the CW use and non-use groups. The frequency of postoperative brain edema was significantly higher in the CW use group than in the non-use group. An adjusted dataset containing 41 patients in the CW use and nonuse groups was generated. Even after PSM, CW implantation had no prognostic effect. CONCLUSIONS: CW implantation with standard treatment demonstrated little beneficial effect for the present strategy of CW use.

    DOI PubMed

  • Clinical Impact of a Local Triage System Using the Emergent Large Vessel Occlusion Screen with a Rotation System of Thrombectomy-Capable Hospitals

    Yusuke Takahashi, Takahiro Ono, Junta Moroi, Jun Maruya, Shuntaro Togashi, Takatsugu Abe, Hajime Nakae, Yasuo Fujita, Shinichi Takahashi, Hiroaki Shimizu

    Journal of Neuroendovascular Therapy ( The Japanese Society for Neuroendovascular Therapy )    2024  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

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    ◆Introduction and explanation【 display / non-display 】

  • Complex Intracranial Aneurysms.

    Shuntaro Togashi, Hiroaki Shimizu

    Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery )  44   225 - 238   2022

    Introduction and explanation (commerce magazine)   Domestic Co-author

    Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.

    DOI PubMed

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    ◆Research society, Symposium materials, etc.【 display / non-display 】

  • Evaluation method of hardness of vessel using balloon catheter

    ITO Yuta, NAGANAWA Akihiro, KOMATSU Kazumi, SEKI Takeshi, HIRASAWA Fujiko, TAKAHASHI Masataka, SHIMIZU Hiroaki

    The Proceedings of Autumn Conference of Tohoku Branch ( The Japan Society of Mechanical Engineers )  2018 ( 0 )   2018

    Research paper (research society, symposium materials, etc.)   Domestic Co-author

    DOI

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    ◆Other【 display / non-display 】

  • Complex Intracranial Aneurysms

    Togashi S、Shimizu H.

    Advances and technical standards in neurosurgery ( Advances and technical standards in neurosurgery )  44   225 - 238   2022  [Invited]

    Domestic Co-author

    Complex intracranial aneurysms remain challenging to treat using standard microsurgical or endovascular techniques. These aneurysms often require a combination of deconstructive and reconstructive procedures, such as parent artery occlusion, flow alteration, and blind-alley formation with or without bypass surgery, for effective and enduring therapeutic effects. It is important to determine the type of bypass based on the site of occlusion of the patent artery, anatomical features of the distal vessels, and expected adequate blood flow. In this chapter, we describe the "Standards," "Advances," and "Controversies" in the context of a microsurgical treatment strategy for complex intracranial aneurysms. "Standards" include a combination of frequent and commonly used procedures that have been gathering a certain consensus on their effectiveness. "Advances" include infrequent, demanding, and/or uncertain surgical procedures that are currently under debate. Finally, "Controversies" discuss a number of unsolved issues.

    DOI PubMed

  • The REAL-WORLD of Elderly PCNSL Therapy in Tohoku and Niigata Area According to Retrospective Analysis: A Collaborative Investigation of the Tohoku Brain Tumor Study Group

    浅野研一郎, 山下洋二, 小野隆裕, 棗田学, 別府高明, 松田憲一朗, 市川優寛, 金森政之, 松坂方士, 黒瀬顕, 齋藤清, 園田順彦, 小笠原邦昭, 藤井幸彦, 清水宏明, 大熊洋揮, 北中千史, 嘉山孝正, 冨永悌二

    日本脳腫瘍学会プログラム・抄録集   38th   2020

    J-GLOBAL

  • Screening of cervical spine diseases by T1 fast spin echo reconstruction images obtained from routine head MRI

    鈴木隼士, 鈴木隼士, 山口卓, 千葉大志, 菅原卓, 清水宏明

    日本脊髄外科学会プログラム・抄録集   35th (CD-ROM)   2020

    Summary of the papers read (national conference and other science council)   Domestic Co-author

    J-GLOBAL

  • REBIRTH as the Activity of the Japanese Society for Neuroendovascular Therapy Tohoku Branch Association

    國分康平, 清水宏明, 松本康史

    脳血管内治療(Web)   4 ( 1 )   2019

    J-GLOBAL

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2023.04  -  2026.03 

  • Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year： 2022.04  -  2025.03 

  • Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year： 2022.04  -  2025.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2018.04  -  2021.03 

  • Development of a new experimental model of chronic cerebral ischemia with vascular endothelial impairment and elucidation of hyperperfusion following vascular reconstruction

    Grant-in-Aid for Scientific Research(C)

    Project Year： 2018.04  -  2021.03  Investigator(s): Shimizu Hiroaki

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Academic Activity 【 display / non-display 】

  • 2021.10
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    Now

  • Japanese Society on Surgery for cerebral Stroke

    2019.04
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  • Japan Stroke Society

    2014.04
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  • 2014.04
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    Now

  • 2010.04
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    Now

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