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大学院医学系研究科（医学専攻等） 医学専攻 病態制御医学系 救急・集中治療医学講座 |
職務経歴（学内） 【 表示 ／ 非表示 】
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2018年09月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 病態制御医学系 准教授
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2016年09月-2018年08月
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 病態制御医学系 講師
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2013年04月-2016年08月
秋田大学 附属病院 集中治療部 助教
学会（学術団体）・委員会 【 表示 ／ 非表示 】
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2013年09月-継続中
日本国
日本外傷学会
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2013年04月-継続中
日本国
日本集中治療医学会
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2012年05月-継続中
日本国
日本災害医学会
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2010年03月-継続中
日本国
日本救急医学会
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1995年07月-継続中
日本国
日本外科学会
研究経歴 【 表示 ／ 非表示 】
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救急医学、集中治療医学
（選択しない）
研究期間：
2013年04月-継続中研究態様：機関内共同研究
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災害医療
（選択しない）
研究期間：
2010年01月-継続中研究態様：機関内共同研究
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食道癌治療
（選択しない）
研究期間：
2000年01月-2013年03月研究態様：機関内共同研究
学位論文 【 表示 ／ 非表示 】
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Soluble and cell-associated forms of some yet to be identified factor in transfused blood which promotes solid tumor growth in mice.
Motoyama S, Saito S, Saito R, Nakamura M, Imano H, Minamiya Y, Ogawa J
Surger Today 34 ( 8 ) 673 - 677 2003年03月
国内共著
研究等業績 【 表示 ／ 非表示 】
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Association Between the Simplest Clinical Factors and Emergency Department Dispositions: A Retrospective Observational Study.
Kasumi Satoh, Manabu Okuyama, Hajime Nakae
Cureus 13 ( 1 ) e12844 2021年01月
研究論文（学術雑誌）
The emergency department (ED) is a complex and busy environment that requires rapid decision making. We assessed the relationship between disposition from the ED and information that can be obtained at a glance in the ED. The presentation of the implications of commonplace information could assist healthcare providers in ensuring smooth and safe ED care. Thus, we aimed to quantitatively assess how readily obtainable findings, such as age, sex, and vital signs, are involved in the disposition of adult patients transferred to the ED. This retrospective observational study was conducted in the ED of a regional university hospital containing approximately 600 beds. Of the 685 patients included in the analysis, 351 patients were admitted to the hospital (including 12 deaths in the ED) and 334 patients were discharged from the ED. A multiple logistic regression model that included age, sex, systolic blood pressure, heart rate, respiration rate, temperature, and SpO2 as variables identified independent associations between age (p=0.003), sex (p<0.001), systolic blood pressure (p=0.023), heart rate (p<0.001), and respiratory rate (p=0.028) and admission from the ED. The receiver operating characteristic curves drawn from the multiple logistic regression model comprising these five variables had an area under the curve (AUC) of 0.701 (95% confidence interval: 0.657-0.744, p<0.001). Examination of sensitivity, specificity, and likelihood ratios (LRs) for these five variables for clinical utility showed a slightly higher sensitivity for age ≥50 years (0.849) and respiratory rate ≥18 bpm (0.769); higher specificity for systolic blood pressure ≤100 mmHg (0.938), pulse rate ≥100 bpm (0.834), and respiratory rate ≥26 bpm (0.887); higher positive LR for systolic blood pressure ≤100 mmHg (2.039) and pulse rate ≥110 bpm (2.729); and slightly lower negative LR for age ≥50 years (0.656), male sex (0.647), respiratory rate ≥20 bpm (0.669). These results are meaningful as they quantify the intuition of a skilled clinician, which can help in clinical decision making, reduce errors, and promote clinical education. Our study provides a basis for explaining to novice healthcare providers that the careful observation of ED patients, even in the absence of special laboratory tests, can help them to make judgments regarding the disposition of the patients from the ED. In conclusion, age, sex, systolic blood pressure, heart rate, and respiratory rate were independently associated with a disposition from the ED. A multivariate model including these five variables showed the moderate-quality potential to predict admission from the ED. The sensitivity, specificity, and LR of systolic blood pressure, heart rate, and respiratory rate showed the characteristics of each vital sign. These provide healthcare providers in the ED an immediate clue regarding the patient's illness.
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The impact of organ dysfunctions on mortality in patients with severe sepsis: A multicenter prospective observational study.
Kudo D, Kushimoto S, Miyagawa N, Sato T, Hasegawa M, Ito F, Yamanouchi S, Honda H, Andoh K, Furukawa H, Yamada Y, Tsujimoto Y, Okuyama M.
Journal of Critical Care 2018年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Comparison of quality of human serum albumin preparations in two pharmaceutical products.
Nakae H, Tomida K, Kikuya Y, Okuyama M, Igarashi T
Acute Medicine & Surgery 2017年07月 [査読有り]
研究論文（学術雑誌） 国内共著
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指揮・安全確保・情報・評価に重点を置いた ブラインド型消火避難訓練
奥山 学, 本山 悟, 五十嵐 季子, 中永 士師明
Japanese Journal of Disaster Medicine 2017年07月 [査読有り]
研究論文（学術雑誌） 国内共著
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Potential therapeutic effect of hainosankyuto on subperiosteal abscess: A case report
Suzuki Y.
Traditional and Kampo Medicine ( Traditional and Kampo Medicine ) 11 ( 3 ) 266 - 267 2024年12月
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Retrospective study on efficacy and safety of Jidabokuippo in real-world clinical practice
Nakae Hajime, Kitamura Toshiharu, Satoh Kasumi, Hirasawa Nobuhisa, Kameyama Koumei, Nara Tasuku, Suzuki Yuya, Yoshida Kenji, Maeno Kyohei, Tsuchida Hideomi, Yasuda Takuto, Saruta Rio, Okuyama Manabu
Personalized Medicine Universe ( 一般社団法人 国際個別化医療学会 ) 13 ( 0 ) 38 - 45 2024年11月
<p>Purpose: Few studies have investigated the treatment outcomes and adverse events after using jidabokuippo (JDI), including the concomitant use of Kampo prescriptions and analgesics. In this study, we retrospectively analyzed the efficacy and safety of JDI in real-world clinical practice.</p><p>Methods: The study included 306 patients who were treated with JDI. Treatment outcomes and adverse events were compared according to age, sex, presence or absence of comorbidities, concomitant use of Kampo prescriptions and analgesics, daily dose of JDI, duration of administration, and the starting time of administration. The patients were divided into two groups: effective and ineffective.</p><p>Results: Concomitant use of Kampo prescriptions and analgesics was observed in 14.1% and 58.2% of the patients, respectively. The efficacy rate of JDI was 97.7%. The duration of JDI treatment in the analgesic group was significantly longer than that in the non-analgesic group (<i>p</i> = 0.0100). None of the patients reported any adverse events.</p><p>Conclusion: The efficacy rate of JDI was as high as 97.7% and no adverse events were observed. Adverse events can be prevented by being cautious of the side effects of Kampo prescriptions. However, the rate of concomitant use of analgesics was high, and the effects of reducing the dosage and frequency of analgesics remains to be determined.</p>
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Yoshida K.
Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 2024年
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Potential risks of cell-free concentrated ascites reinfusion therapy in TAFRO syndrome patient
Satoh K.
Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 28 ( 3 ) 477 - 478 2024年
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Suzuki Y.
Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 27 ( 6 ) 1028 - 1034 2023年12月
INTRODUCTION: Coronavirus disease 2019 (COVID-19) is associated with a marked increase in the inflammatory cytokines, IL-6 and IL-18. Blood purification therapy aimed at controlling cytokines is one treatment option; however, evidence of its effectiveness is needed. Plasma exchange with dialysis (PED) is a blood purification method involving selective plasma exchange with dialysate flowing through the outer hollow fiber of the plasma separator. In this retrospective study, we investigated the efficacy of continuous PED (cPED) over 48 h in five patients with severe COVID-19. METHODS: We assessed changes in IL-6 and IL-18, as well as adiponectin (APN). RESULTS: There were no significant differences in changes in IL-6 and IL-18, but there was a marked improvement in cases with abnormally high IL-6 and IL-18 levels at baseline. APN, which inhibits inflammatory cytokines, was significantly elevated post-cPED. CONCLUSION: Our results suggest that cPED therapy is an effective treatment for COVID-19.
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科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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輸血が癌増殖に及ぼす影響。特に可溶性MHC classIの関与についての研究
基盤研究(C)
研究期間: 2005年04月 - 2007年03月