研究者詳細 - 後藤　明輝

Proceedings of the National Academy of Sciences of the United States of America ( Proceedings of the National Academy of Sciences of the United States of America ) 121 ( 36 ) 2024年09月 [査読有り]

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Research autopsy programmes in oncology: shared experience from 14 centres across the world

Geukens T.

Journal of Pathology ( Journal of Pathology ) 263 ( 2 ) 150 - 165 2024年06月 [査読有り]

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

白石航也, 高橋篤, 桃沢幸秀, 醍醐弥太郎, 金子修三, 川口喬久, 國頭英夫, 松本慎吾, 堀之内秀仁, 後藤明輝, 本多隆行, 清水公裕, 虎澤匡洋, 高柳大輔, 齋藤元伸, 斎藤聡, 大江裕一郎, 渡辺俊一, 後藤功一, 坪井正博, 土原一哉, 髙田定暁, 碧井智美, 高野淳, 小林正嗣, 宮城洋平, 田中和美, 鈴木弘行, 前田大地, 山浦匠, 松田麻衣子, 島田陽子, 水野孝昭, 坂本裕美, 吉田輝彦, 後藤悌, 吉田達哉, 山地太樹, 園部誠, 豊岡伸一, 米田和恵, 真砂勝泰, 田中文啓, 原めぐみ, 布施昇男, 西塚哲, 元井紀子, 澤田典絵, 西田裕一郎, 熊田和貴, 竹内研時, 丹野高三, 谷田部恭, 角南久仁子, 菱田智之, 宮崎泰成, 伊藤秀美, 雨宮光宏, 戸塚裕彦, 中山治彦, 横瀬智之, 石垣和慶, 永島宗晃, 大瀧容一, 今井一博, 高澤建, 南谷佳弘, 小林和馬, 大久保憲一, 若井建志, 清水厚志, 山本雅之, 岩崎基, 松田浩一, 稲澤譲治, 白石友一, 西川博嘉, 村上善則, 久保充明, 松田文彦, 鎌谷洋一郎, 浜本隆二, 松尾恵太郎, 河野隆志

Cancer Communications ( Wiley ) 44 ( 2 ) 287 - 293 2024年02月 [査読有り]

非喫煙者に多いEGFR変異肺腺がんへのかかりやすさを解明肺腺がんの予防・早期発見にむけた手がかりとして期待. 京都大学プレスリリース. 2023-11-09.

CiNii Research

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

Shiraishi K.

Cancer Communications ( Cancer Communications ) 44 ( 2 ) 287 - 293 2024年02月

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Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry

Yoshimura K.

Pathology International ( Pathology International ) 74 ( 4 ) 187 - 196 2024年 [査読有り]

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Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens

Miyauchi Toshiya, Narita Shintaro, Saiki Yuriko, Kudo-Asabe Yukitsugu, Horii Akira, Fukushige Shinichi, Habuchi Tomonori, Nanjo Hiroshi, Goto Akiteru

The Tohoku Journal of Experimental Medicine ( 東北ジャーナル刊行会 ) 264 ( 4 ) 203 - 213 2024年

The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3–4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3–4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.

DOI PubMed CiNii Research

Localized median tongue AL amyloidosis accompanied with chondroid metaplasia: the possible etiology and relationship to median rhomboid glossitis

Oikawa Y.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ) 37 ( 3 ) 571 - 575 2024年 [査読有り]

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Shi J.

Nature Communications ( Nature Communications ) 14 ( 1 ) 2023年12月 [査読有り]

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A Case of Papillary Lung Adenocarcinoma Derived from Malignant Transformation of Papillary Adenoma

Takahashi S.

Japanese Journal of Lung Cancer ( Japanese Journal of Lung Cancer ) 63 ( 4 ) 314 - 318 2023年08月

背景．肺乳頭腺腫は非常に稀であるが，肺腺癌へ悪性転化する場合がある．今回我々は，肺乳頭腺腫の悪性転化と考えられた乳頭型肺腺癌の1例を経験した．症例．45歳男性．X－8年前にCTで偶発的に右下葉に結節影を認め，外科的生検を検討していたが，通院を自己中断した．X年に右背部痛を主訴に近医を受診し，CTで右下葉結節影が認められたため，精査・加療目的に当科へ紹介された．気管支鏡検査で肺腺癌の疑いと診断を得たため，右下葉切除＋縦隔リンパ節郭清術を施行した．肉眼的所見では，20 mm大の境界明瞭な類円形の腫瘍であった．病理学的所見では，乳頭状増殖を示し，腫瘍辺縁には置換性増殖もみられた．臨床経過や画像，肉眼所見は乳頭腺腫を示唆する所見であったが，核異型が比較的高度である点や置換性増殖を認める点から，乳頭型肺腺癌と診断した．また次世代シーケンサーによる遺伝子解析では，CTNNB1遺伝子変異が陽性であった．結論．乳頭腺腫が肺腺癌へ悪性転化したと考えられた非常に稀な症例を経験した．

DOI CiNii Research

CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress

Takahashi S.

Frontiers in Oncology ( Frontiers in Oncology ) 13 2023年 [査読有り]

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Exosomes secreted by ST3GAL5high cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment

Horie M.

Molecular Oncology ( Molecular Oncology ) 18 ( 1 ) 21 - 43 2023年 [査読有り]

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

Shiraishi K.

Cancer Communications ( Cancer Communications ) 2023年 [査読有り]