Research Achievements - Other -
-
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
白石 航也, 高橋 篤, 桃沢 幸秀, 醍醐 弥太郎, 金子 修三, 川口 喬久, 國頭 英夫, 松本 慎吾, 堀之内 秀仁, 後藤 明輝, 本多 隆行, 清水 公裕, 虎澤 匡洋, 高柳 大輔, 齋藤 元伸, 斎藤 聡, 大江 裕一郎, 渡辺 俊一, 後藤 功一, 坪井 正博, 土原 一哉, 髙田 定暁, 碧井 智美, 高野 淳, 小林 正嗣, 宮城 洋平, 田中 和美, 鈴木 弘行, 前田 大地, 山浦 匠, 松田 麻衣子, 島田 陽子, 水野 孝昭, 坂本 裕美, 吉田 輝彦, 後藤 悌, 吉田 達哉, 山地 太樹, 園部 誠, 豊岡 伸一, 米田 和恵, 真砂 勝泰, 田中 文啓, 原 めぐみ, 布施 昇男, 西塚 哲, 元井 紀子, 澤田 典絵, 西田 裕一郎, 熊田 和貴, 竹内 研時, 丹野 高三, 谷田部 恭, 角南 久仁子, 菱田 智之, 宮崎 泰成, 伊藤 秀美, 雨宮 光宏, 戸塚 裕彦, 中山 治彦, 横瀬 智之, 石垣 和慶, 永島 宗晃, 大瀧 容一, 今井 一博, 高澤 建, 南谷 佳弘, 小林 和馬, 大久保 憲一, 若井 建志, 清水 厚志, 山本 雅之, 岩崎 基, 松田 浩一, 稲澤 譲治, 白石 友一, 西川 博嘉, 村上 善則, 久保 充明, 松田 文彦, 鎌谷 洋一郎, 浜本 隆二, 松尾 恵太郎, 河野 隆志
Cancer Communications ( Wiley ) 44 ( 2 ) 287 - 293 2024.02 [Refereed]
非喫煙者に多いEGFR変異肺腺がんへのかかりやすさを解明 肺腺がんの予防・早期発見にむけた手がかりとして期待. 京都大学プレスリリース. 2023-11-09.
-
Miyauchi Toshiya, Narita Shintaro, Saiki Yuriko, Kudo-Asabe Yukitsugu, Horii Akira, Fukushige Shinichi, Habuchi Tomonori, Nanjo Hiroshi, Goto Akiteru
The Tohoku Journal of Experimental Medicine ( 東北ジャーナル刊行会 ) 264 ( 4 ) 203 - 213 2024
<p>The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3–4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3–4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.</p>
-
Shi J.
Nature Communications ( Nature Communications ) 14 ( 1 ) 2023.12 [Refereed]
-
A Case of Papillary Lung Adenocarcinoma Derived from Malignant Transformation of Papillary Adenoma
Takahashi Shugo, Saito Yoshitaro, Murakami Masayo, Goto Akiteru, Matsuzaki Ikuo
Haigan ( The Japan Lung Cancer Society ) 63 ( 4 ) 314 - 318 2023.08
<p><b><i>Background. </i></b>Pulmonary papillary adenoma may malignantly transform into lung adenocarcinoma, although this is very rare. We herein report a case of papillary lung adenocarcinoma derived from malignant transformation of papillary adenoma. <b><i>Case. </i></b>A 45-year-old man was referred to our department for the examination and treatment of a nodular shadow in the right lower lobe on computed tomography (CT) performed by a primary care physician because of right back pain. Eight years previously, a nodular shadow was incidentally found in the right lower lung lobe on CT, and surgical biopsy was considered. However, the patient had refused to address it. Bronchoscopy raised the suspicion of lung adenocarcinoma, and right lower lung lobe resection and mediastinal lymph node dissection were performed. Grossly, the tumor was well-defined, round, and 20 mm in diameter. A pathological examination revealed papillary proliferation and lepidic growth at the tumor margin. Although the clinical course, imaging and gross findings were suggestive of papillary adenoma, the diagnosis of papillary lung adenocarcinoma was made based on the relatively high degree of nuclear atypia and the presence of lepidic growth. In addition, CTNNB1 mutation was detected, which suggested malignant transformation. <b><i>Conclusion. </i></b>We report a very rare case of papillary adenoma with malignant transformation into lung adenocarcinoma.</p>
-
Takahashi S.
Frontiers in Oncology ( Frontiers in Oncology ) 13 2023 [Refereed]
-
Horie M.
Molecular Oncology ( Molecular Oncology ) 18 ( 1 ) 21 - 43 2023 [Refereed]
-
Shiraishi K.
Cancer Communications ( Cancer Communications ) 2023 [Refereed]
-
Ito Yukinobu, Goto Akiteru
46 ( 1 ) 29 - 37 2019.06 [Refereed]