研究者詳細 - 後藤　明輝

非外傷性脾破裂（ASR）は悪性リンパ腫の致死的合併症である。血管内大細胞型B細胞リンパ腫（IVLBCL）に伴うASR（IVLBCL-ASR）の報告は過去に1例のみで，その機序は不明な点が多い。今回我々は，剖検所見からIVLBCL-ASRと診断した1例を報告する。症例は78歳男性。IVLBCLの精査中に出血性ショックのため突然死し，剖検所見で大量の血性腹水と脾破裂を認めた。全身の小血管内にCD20陽性大型異型リンパ球の浸潤を認めIVLBCLと診断し，腫瘍細胞浸潤は裂創部位を含めた脾被膜部ではわずかで脾臓中心部で著明で，脾中心部での腫瘍増殖による脾内圧亢進がASRの原因と考えられIVLBCL-ASRと確定診断した。患者は入院3ヶ月前に舌がんの精査目的で施行された18F-FDG PET/CT検査で右副腎に異常集積を認めており，病理所見では同部位に一致して腫瘍浸潤を認めた。IVLBCLの早期診断における18F-FDG PET/CT検査の有用性を再認識し，IVLBCLの進行に伴いASRの発症リスクが上昇することが示唆され，早期の全身化学療法の実施が重要であると考えられた。

DOI CiNii Research

PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms

Nakano H.

Scientific Reports ( Scientific Reports ) 11 ( 1 ) 2021年12月

研究論文（学術雑誌）国際共著

DOI

Collision of Epstein–Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report

Miyabe K.

BMC Gastroenterology ( BMC Gastroenterology ) 21 ( 1 ) 2021年12月

研究論文（学術雑誌）

DOI

Disorganization of intercalated discs in dilated cardiomyopathy

Ito Y.

Scientific Reports ( Scientific Reports ) 11 ( 1 ) 2021年12月

研究論文（学術雑誌）国際共著

DOI

Comprehensive immunohistochemical analysis of the gastrointestinal and Müllerian phenotypes of 139 ovarian mucinous cystadenomas

Halimi S.A.

Human Pathology ( Human Pathology ) 109 21 - 30 2021年03月 [査読有り]

研究論文（学術雑誌）国際共著

DOI

Detection of MED12 mutations in mesenchymal components of uterine adenomyomas

Kito M.

Human Pathology ( Human Pathology ) 109 31 - 36 2021年03月 [査読有り]

研究論文（学術雑誌）国際共著

DOI

CADM1 promotes malignant features of small-cell lung cancer by recruiting 4.1R to the plasma membrane

Funaki T.

Biochemical and Biophysical Research Communications ( Biochemical and Biophysical Research Communications ) 534 172 - 178 2021年01月 [査読有り]

研究論文（学術雑誌）

DOI

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7

Miyauchi T.

Disease Markers ( Disease Markers ) 2021 2021年 [査読有り]

研究論文（学術雑誌）

DOI

Time Changes in the VEGF-A Concentration Gradient Lead Neovasculature to Engage in Stair-Like Growth

Ito Y.

Springer Proceedings in Mathematics and Statistics ( Springer Proceedings in Mathematics and Statistics ) 370 226 - 234 2021年 [査読有り]

研究論文（学術雑誌）

DOI

Clinicopathological and molecular analyses of linearly expanded epithelial cells with β-catenin alterations, “β-catenin signature”, in the normal fallopian tube

Koyama K.

Histopathology ( Histopathology ) 77 ( 6 ) 880 - 889 2020年12月 [査読有り]

研究論文（学術雑誌）

DOI

Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule

Nomura Y.

Genes Chromosomes and Cancer ( Genes Chromosomes and Cancer ) 59 ( 12 ) 702 - 708 2020年12月 [査読有り]

研究論文（学術雑誌）

DOI

Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”

Takai E.

Scientific Reports ( Scientific Reports ) 10 ( 1 ) 2020年12月 [査読有り]

研究論文（学術雑誌）

DOI

Multiple ulcerations and perforation in the small intestine after steroid treatment in eosinophilic granulomatosis with polyangiitis: a case report and literature review

Ito Y.

Cardiovascular Pathology ( Cardiovascular Pathology ) 47 2020年07月 [査読有り]

研究論文（学術雑誌）

DOI

An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array

Tamura D.

Genes Chromosomes and Cancer ( Genes Chromosomes and Cancer ) 59 ( 3 ) 209 - 213 2020年03月 [査読有り]

研究論文（学術雑誌）

DOI

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Wong J.Y.Y.

Genomics ( Genomics ) 112 ( 2 ) 1223 - 1232 2020年03月 [査読有り]

研究論文（学術雑誌）

DOI

A case of Russell body gastritis with multifocal lesions

Michinobu Umakoshi, Ken Miyabe, Hajime Ishii, Yukitsugu Kudo-Asabe, Yukinobu Ito, Makoto Yoshida, Daichi Maeda, Masato Sageshima, Akiteru Goto

SAGE Open Medical Case Reports ( SAGE Publications ) 8 2050313X2092384 2020年01月 [査読有り]

研究論文（学術雑誌）

<jats:p>Russell body gastritis is an extremely rare gastritis characterized by abundant infiltration of plasma cells with Russell body and eccentric nuclei, known as Mott cells. An 81-year-old Japanese woman with Helicobacter pylori and hepatitis C virus infection complaining of abdominal discomfort underwent upper gastrointestinal endoscopy, which detected an elevated lesion 2 cm in diameter at the anterior wall of the gastric body. A histological examination of the lesion revealed the infiltration of numerous Mott cells with an abundant eosinophilic crystal structure and eccentric nuclei in the lamina propria, resulting in a pathological diagnosis of Russell body gastritis. Endoscopic submucosal dissection (ESD) was performed subsequently. The histological findings of the resected specimen were compatible with those of Russell body gastritis. Upper gastrointestinal endoscopy performed 2 months after endoscopic submucosal dissection revealed the presence of new multiple flat elevated lesions in the antrum up to 1 cm in diameter, distant from the site of endoscopic submucosal dissection. A histological examination revealed a few Mott cells in the biopsy specimens taken from the new lesions. In turn, H. pylori eradication therapy was performed 1 month after the detection of the new lesions. One year after the eradication therapy, follow-up upper gastrointestinal endoscopy revealed that multiple lesions had almost disappeared, and the histological examination of the gastric biopsy specimens confirmed the disappearance of Mott cells. We herein report a case of Russell body gastritis in which multifocal lesions were observed after endoscopic submucosal dissection, and which was subsequently treated by H. pylori eradication therapy.</jats:p>

DOI CiNii Research

Prognostic role of ARID1A negative expression in gastric cancer

Ashizawa M.

Scientific Reports ( Scientific Reports ) 9 ( 1 ) 2019年12月 [査読有り]

研究論文（学術雑誌）

DOI

Distribution of Tattoo Pigment in Lymph Nodes Dissected for Gynecological Malignancy

Tamura D.

International Journal of Surgical Pathology ( International Journal of Surgical Pathology ) 27 ( 7 ) 773 - 777 2019年10月 [査読有り]

研究論文（学術雑誌）

DOI

Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies

Akiyama Y.

Journal of Urology ( Journal of Urology ) 202 ( 2 ) 290 - 300 2019年08月 [査読有り]

研究論文（学術雑誌）

DOI

Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies

Yoshiyuki Akiyama, Daichi Maeda, Hiroto Katoh, Teppei Morikawa, Aya Niimi, Akira Nomiya, Yusuke Sato, Taketo Kawai, Akiteru Goto, Tetsuya Fujimura, Hiroshi Fukuhara, Tohru Nakagawa, Yasuhiko Igawa, Shumpei Ishikawa, Masashi Fukayama, Haruki Kume, Yukio Homma

Journal of Urology ( Ovid Technologies (Wolters Kluwer Health) ) 202 ( 2 ) 290 - 300 2019年08月 [査読有り]

研究論文（学術雑誌）

DOI CiNii Research

Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment

Umakoshi M.

Oncogene ( Oncogene ) 38 ( 12 ) 2162 - 2176 2019年03月 [査読有り]

研究論文（学術雑誌）

DOI

Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy

Kanke Y.

Oncology Letters ( Oncology Letters ) 17 ( 1 ) 921 - 926 2019年01月 [査読有り]

研究論文（学術雑誌）

DOI

Immunoglobulin light chain amyloidosis with severe liver dysfunction accompanied by factor X deficiency

Guo Y.M.

Internal Medicine ( Internal Medicine ) 58 ( 20 ) 3039 - 3043 2019年 [査読有り]

研究論文（学術雑誌）国内共著

Severe hepatic failure is rarely a cause of death in patients with immunoglobulin light chain (AL) amyloidosis. We herein report a case of AL amyloidosis involving a bleeding tendency due to factor X deficiency and marked hepatic involvement of amyloidosis. The patient died due to severe liver dysfunction two weeks after admission. The diagnosis was confirmed histologically by AL-λ amyloidosis, with the liver and spleen as the main lesions, on an autopsy. As treatment-related toxicity is strong in advanced cases, appropriate treatments are required to improve the prognosis of AL amyloidosis with severe liver dysfunction.

DOI

Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression

Tamura D.

Histopathology ( Histopathology ) 73 ( 6 ) 1013 - 1022 2018年12月 [査読有り]

研究論文（学術雑誌）

DOI

MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression

Kunita A.

Scientific Reports ( Scientific Reports ) 8 ( 1 ) 2018年12月 [査読有り]

研究論文（学術雑誌）

DOI

Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation

Ito Y.

Scientific Reports ( Scientific Reports ) 8 ( 1 ) 2018年12月 [査読有り]

研究論文（学術雑誌）

DOI

MED12 is frequently mutated in ovarian and other adnexal leiomyomas.

Li Z, Maeda D, Kudo-Asabe Y, Tamura D, Nanjo H, Hayashi A, Ikemura M, Fukayama M, Goto A.

Human Pathology 81 89 - 95 2018年11月 [査読有り]

研究論文（学術雑誌）国内共著

MED12 is frequently mutated in ovarian and other adnexal leiomyomas

Li Z.

Human Pathology ( Human Pathology ) 81 89 - 95 2018年11月 [査読有り]

研究論文（学術雑誌）

DOI

The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer

Li Z.

Lung Cancer ( Lung Cancer ) 123 127 - 135 2018年09月 [査読有り]

研究論文（学術雑誌）

DOI

The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer.

Li Z, Maeda D, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Konno H, Saito H, Minamiya Y, Goto A.

Lung Cancer 123 127 - 135 2018年07月 [査読有り]

研究論文（学術雑誌）国内共著

DOI

Development of targeted therapy and immunotherapy for treatment of small cell lung cancer

Saito M.

Japanese Journal of Clinical Oncology ( Japanese Journal of Clinical Oncology ) 48 ( 7 ) 603 - 608 2018年07月 [査読有り]

研究論文（学術雑誌）国内共著

DOI

Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer

Saito M.

Oncology Letters ( Oncology Letters ) 15 ( 2 ) 2401 - 2406 2018年02月 [査読有り]

研究論文（学術雑誌）

DOI

Digital quantitative analysis of mast cell infiltration in interstitial cystitis

Akiyama Y.

Neurourology and Urodynamics ( Neurourology and Urodynamics ) 37 ( 2 ) 650 - 657 2018年02月 [査読有り]

研究論文（学術雑誌）

DOI

Disruption of Small GTPase Rab7 exacerbates the severity of acute pancreatitis in experimental mouse models

Takahashi K.

Scientific Reports ( Scientific Reports ) 7 ( 1 ) 2017年12月 [査読有り]

研究論文（学術雑誌）

DOI

Fetal gut–like differentiation in gallbladder cancer

Koyama K.

Human Pathology ( Human Pathology ) 70 27 - 34 2017年12月 [査読有り]

研究論文（学術雑誌）

DOI

Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer

Motonobu Saito, Katsuharu Saito, Kouya Shiraishi, Daichi Maeda, Hiroyuki Suzuki, Yoshihiro Minamiya, Koji Kono, Takashi Kohno, Akiteru Goto

Molecular and Clinical Oncology ( Spandidos Publications ) 2017年12月 [査読有り]

研究論文（学術雑誌）

DOI CiNii Research

Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing

Ito Y.

Virchows Archiv ( Virchows Archiv ) 471 ( 3 ) 423 - 428 2017年09月 [査読有り]

研究論文（学術雑誌）

DOI

The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.

Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D.

PLoS One 12 ( 7 ) e018881270 2017年07月 [査読有り]

研究論文（学術雑誌）国内共著

DOI

The low expression of MIR-451 predicts a worse prognosis in non-small cell lung cancer cases

Goto A.

PLoS ONE ( PLoS ONE ) 12 ( 7 ) 2017年07月 [査読有り]

研究論文（学術雑誌）

DOI

PIK3CA and AKT1 mutations in hidradenoma papilliferum

Goto K.

Journal of Clinical Pathology ( Journal of Clinical Pathology ) 70 ( 5 ) 424 - 427 2017年05月 [査読有り]

研究論文（学術雑誌）

DOI

Mesothelial cells create a novel tissue niche that facilitates gastric cancer invasion

Tanaka M.

Cancer Research ( Cancer Research ) 77 ( 3 ) 684 - 695 2017年02月 [査読有り]

研究論文（学術雑誌）

DOI

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Seow W.J.

Human Molecular Genetics ( Human Molecular Genetics ) 26 ( 2 ) 454 - 465 2017年 [査読有り]

研究論文（学術雑誌）

DOI

Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy

Kimura H.

JCI Insight ( JCI Insight ) 2 ( 1 ) 2017年 [査読有り]

研究論文（学術雑誌）

DOI

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