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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Quantitative Pathology |
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Laboratory Address |
Hondo 1-1-1, Akita City, 010-8543, Japan |
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Mail Address |
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GOTO Akiteru
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Graduating School 【 display / non-display 】
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-1995.03
The University of Tokyo Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-1999.03
The University of Tokyo Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2011.10-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Professor
Research Achievements 【 display / non-display 】
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Zhou J.
Sensors and Actuators Reports ( Sensors and Actuators Reports ) 11 2026.06
Research paper (journal) International Co-author
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Momma T.
International Journal of Molecular Sciences ( International Journal of Molecular Sciences ) 27 ( 1 ) 2026.01 [Refereed]
Research paper (journal)
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Akiyama Y.
Scientific Reports ( Scientific Reports ) 15 ( 1 ) 2025.12 [Refereed]
Research paper (journal)
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Kimura T.
Oncogene ( Oncogene ) 44 ( 43 ) 4101 - 4113 2025.11 [Refereed]
Research paper (journal)
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Cho H.
Journal of Thoracic Oncology ( Journal of Thoracic Oncology ) 20 ( 11 ) 1626 - 1638 2025.11 [Refereed]
Research paper (journal) International Co-author
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Evaluation of human papillomavirus infection and p16 expression in bladder cancer
Miyabe Ken, Tsukita Hikaru, Yoshida Makoto, Kudo-Asabe Yukitsugu, Ito Yukinobu, Nanjo Hiroshi, Narita Shintaro, Goto Akiteru
秋田医学 ( 秋田医学会 ) 52 ( 3-4 ) 61 - 65 2025.11 [Refereed]
Background: The involvement of human papillomavirus（HPV）in bladder cancer remains unclear. This study aimed to investigate the relationship between HPV infection and the expression of p16, a surrogate marker of HPV infection, in bladder cancer tissues.
Methods: We retrospectively analyzed 132 surgically treated patients with bladder cancer. HPV DNA detection was performed using in situ hybridization（ISH）, and the expression of p16 was assessed using immunohistochemistry（IHC）. The correlation between HPV ISH results and the expression of p16 was evaluated.
Results: HPV DNA was detected in 4 of the 132 cases（3%）. Among the 67 p16-positive cases （50.8%）, 3 were HPV DNA-positive. There was no significant association between HPV DNA positivity and the expression of p16（p = 0.6194）.
Conclusion: HPV infection was observed in a small proportion of bladder cancer cases and the p16 expression was not significantly correlated with the HPV status. These findings suggest that p16 immunostaining may not be a reliable surrogate marker for HPV infection in bladder cancer. Further research is required to clarify the role of HPV in bladder carcinogenesis. -
Zhou J.
Iscience ( Iscience ) 28 ( 11 ) 2025.11 [Refereed]
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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
白石 航也, 高橋 篤, 桃沢 幸秀, 醍醐 弥太郎, 金子 修三, 川口 喬久, 國頭 英夫, 松本 慎吾, 堀之内 秀仁, 後藤 明輝, 本多 隆行, 清水 公裕, 虎澤 匡洋, 高柳 大輔, 齋藤 元伸, 斎藤 聡, 大江 裕一郎, 渡辺 俊一, 後藤 功一, 坪井 正博, 土原 一哉, 髙田 定暁, 碧井 智美, 高野 淳, 小林 正嗣, 宮城 洋平, 田中 和美, 鈴木 弘行, 前田 大地, 山浦 匠, 松田 麻衣子, 島田 陽子, 水野 孝昭, 坂本 裕美, 吉田 輝彦, 後藤 悌, 吉田 達哉, 山地 太樹, 園部 誠, 豊岡 伸一, 米田 和恵, 真砂 勝泰, 田中 文啓, 原 めぐみ, 布施 昇男, 西塚 哲, 元井 紀子, 澤田 典絵, 西田 裕一郎, 熊田 和貴, 竹内 研時, 丹野 高三, 谷田部 恭, 角南 久仁子, 菱田 智之, 宮崎 泰成, 伊藤 秀美, 雨宮 光宏, 戸塚 裕彦, 中山 治彦, 横瀬 智之, 石垣 和慶, 永島 宗晃, 大瀧 容一, 今井 一博, 高澤 建, 南谷 佳弘, 小林 和馬, 大久保 憲一, 若井 建志, 清水 厚志, 山本 雅之, 岩崎 基, 松田 浩一, 稲澤 譲治, 白石 友一, 西川 博嘉, 村上 善則, 久保 充明, 松田 文彦, 鎌谷 洋一郎, 浜本 隆二, 松尾 恵太郎, 河野 隆志
Cancer Communications ( Wiley ) 44 ( 2 ) 287 - 293 2024.02 [Refereed]
非喫煙者に多いEGFR変異肺腺がんへのかかりやすさを解明 肺腺がんの予防・早期発見にむけた手がかりとして期待. 京都大学プレスリリース. 2023-11-09.
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Miyauchi Toshiya, Narita Shintaro, Saiki Yuriko, Kudo-Asabe Yukitsugu, Horii Akira, Fukushige Shinichi, Habuchi Tomonori, Nanjo Hiroshi, Goto Akiteru
The Tohoku Journal of Experimental Medicine ( 東北ジャーナル刊行会 ) 264 ( 4 ) 203 - 213 2024
<p>The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3–4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3–4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.</p>
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Shi J.
Nature Communications ( Nature Communications ) 14 ( 1 ) 2023.12 [Refereed]
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2023.04 - 2027.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03