OMORI Yasufumi

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Oncoregulatory Medicine  Department of Molecular Pathology and Tumor Pathology

Research Interests 【 display / non-display

  • cell-cell interaction

  • E-cadherin

  • E-カドヘリン

  • gap junction

  • p120catenin

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Graduating School 【 display / non-display

  •  
    -
    1992

    Tohoku University     Graduated

  •  
    -
    1992

    Tohoku University     Graduated

  • 1982.04
    -
    1988.03

    Tohoku University   Faculty of Medicine   School of Medicine   Graduated

  •  
    -
    1988

    Tohoku University   Faculty of Medicine   Graduated

  •  
    -
    1988

    Tohoku University   Faculty of Medicine   School of Medicine   Graduated

Graduate School 【 display / non-display

  • 1988.04
    -
    1992.03

    Tohoku University  Graduate School,Division of Medicine  Pathology  Doctor's Course  Completed

Degree 【 display / non-display

  • Tohoku University -  Doctor of Medical Science

  • Tohoku University -  Bachelor (Medicine)

Campus Career 【 display / non-display

  • 2014.04
    -
    2016.03

    Akita University   Hospital   Division of Clinical Pathology   Professor  

  • 2013.05
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Professor  

  • 2010.01
    -
    2013.04

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Associate Professor  

  • 2007.04
    -
    2009.12

    Akita University   Graduate School of Medicine   Lecturer  

  • 2002.01
    -
    2007.03

    Akita University   School of Medicine   School of Medicine   Lecturer  

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External Career 【 display / non-display

  • 2013.05
     
     

    Akita University Graduate School of Medicine   Department of Molecular and Tumour Pathology   Professor and Chaiman  

Research Areas 【 display / non-display

  • Life Science / Experimental pathology

  • Life Science / Cell biology

  • Life Science / Molecular biology

 

Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma

    Yohei Kawasaki, Yasufumi Omori, Shinsuke Suzuki, Takechiyo Yamada

    Archives of Medical Science ( Termedia Sp. z.o.o. )  19 ( 6 ) 1859 - 1868   2023.12  [Refereed]

    Research paper (journal)   Domestic Co-author

    <jats:sec><jats:title>Introduction</jats:title><jats:p>The prognosis of head and neck squamous cell carcinoma (HNSCC) is generally good in cases of high radiation sensitivity but poor in cases exhibiting radiation resistance; this resistance has been attributed to the presence of cancer stem cells. In recent years, CD98hc overexpression has been associated with poor prognosis in various types of cancers. CD98 is a heterodimer of heavy and light chains and is strongly involved in cell proliferation, survival, migration, and adhesion. We investigated whether CD98hc can be used as a cancer stem cell marker for HNSCC.</jats:p></jats:sec><jats:sec><jats:title>Material and methods</jats:title><jats:p>We exposed five HNSCC cell lines to a total radiation dose of 60 Gy administered in 2 Gy fractions on consecutive days to investigate changes in CD98hc expression. Furthermore, we separated CD98-positive and CD98-negative cell populations to comparatively investigate the properties of each.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Radiation resistance was observed in all five cell lines, and resistant cells exhibited CD98hc overexpression, with enhanced spheroid formation, migratory, and invasive abilities. Radiation-resistant cell lines were separated into CD98-positive and CD98-negative populations. CD98hc-positive radiation-resistant cell lines exhibited enhanced spheroid formation, invasion, and plating efficiency as well as strong tumorigenicity in nude mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>CD98hc-positive cells exhibited cancer stem cell-like properties in all cell lines. Thus, CD98hc is a potential marker of radiation sensitivity as well as a potential therapeutic target for improved survival rates of patients with HNSCC.</jats:p></jats:sec>

    DOI CiNii Research

  • Endocytic trafficking of connexins in cancer pathogenesis

    Totland M.Z.

    Biochimica et Biophysica Acta - Molecular Basis of Disease ( Biochimica et Biophysica Acta - Molecular Basis of Disease )  1869 ( 7 )   2023.10  [Refereed]

    Research paper (journal)   International Co-author

    DOI

  • LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma

    Kawasaki Y.

    Oncology Letters ( Oncology Letters )  25 ( 4 ) 171   2023.04  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI CiNii Research

  • A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates

    Suzuki M.

    FEBS Open Bio ( FEBS Open Bio )  13 ( 3 ) 434 - 446   2023.03  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • CD98 expression can be a predictive factor of resistance to radiotherapy in head and neck squamous cell carcinoma

    Suzuki H.

    Polish Journal of Pathology ( Polish Journal of Pathology )  74 ( 2 ) 122 - 130   2023  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

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    ◆Other【 display / non-display

  • Amyloid β-related angiitis presented only a leptomeningeal legion and enlarged perivascular spaces without detection of hemorrhagic lesions at first visit: a case report

    Ichikawa Dai, Yanagisawa Toshiharu, Omori Yasufumi, Kamada Sachiko

    Japanese Journal of Stroke ( The Japan Stroke Society )  advpub ( 0 )   2023

    <p>A 70-year-old woman visited our hospital with a chief complaint of headache. T2-weighted and fluid-attenuated inversion-recovery magnetic resonance imaging (MRI) showed a leptomeningeal lesion in the right temporal lobe and many enlarged perivascular spaces in the centrum semiovale. Follow-up MRI performed 6 months later revealed cortical microbleeds and cortical superficial siderosis. Three years later, the patient presented with right lower quadrant homonymous hemianopsia and disturbance of consciousness. MRI showed diffuse leptomeningeal and significantly increased hemorrhagic lesions. A brain biopsy confirmed diagnosis of amyloid β-related angiitis. Disturbance of consciousness persisted despite steroid treatment. We concluded that vasculitis-induced inflammation preceded bleeding secondary to vascular fragility in our patient. Inflammatory cerebral amyloid angiopathy should be included in the differential diagnosis in patients with early-onset leptomeningeal lesions and enlarged perivascular spaces without hemorrhagic lesions.</p>

    DOI CiNii Research

  • Endovascular treatment of acute intracranial large-vessel occlusion caused by a thrombus in the cervical internal carotid artery

    Omae Tomoya, Yanagisawa Toshiharu, Omori Yasufumi

    NEUROSURGICAL EMERGENCY ( Japan Society of Neurosurgical Emergency )  27 ( 2 ) 153 - 158   2022

    <p>  We describe a case in which a cardiogenic thrombus at the cervical internal carotid artery migrated to the middle cerebral artery. The patient was a 69‒year‒old female who had mild neurological symptoms. At her first visit, magnetic resonance diffusion‒weighted imaging indicated no acute ischemic lesion. Magnetic resonance angiography revealed occlusion of the right internal carotid artery and a patent middle cerebral artery supplied via the posterior communicating artery. The next day, the patient exhibited left hemiparesis and occlusion of both the internal carotid artery and middle cerebral artery. A mechanical thrombectomy was performed. Complete recanalization was achieved, and the patient's neurological deficits were resolved. The mechanical thrombectomy was effective for this emergency state of thrombus migration from the cervical internal carotid artery to the terminus of the internal carotid artery. The present case demonstrates that it is possible for a thrombus of the cervical internal carotid artery to migrate to a distal intracranial artery and result in severe symptoms. In the event of such an emergency, a system for rapid treatment by mechanical thrombectomy is needed.</p>

    DOI CiNii Research

  • 好酸球増多疾患・好酸球性肺炎 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者

    福地 峰世, 植木 重治, 山本 洋平, 奈良 美保, 今野 泰典, 面川 歩, 嵯峨 知生, 守時 由起, 大森 泰文, 高橋 直人, 廣川 誠

    アレルギー ( (一社)日本アレルギー学会 )  68 ( 4-5 ) 529 - 529   2019.05

Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2025.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2019.04  -  2022.03