Basic Information 【 display / non-display

KUBOTA Hitoshi

写真a

Affiliation

Graduate School of Engineering Science , Department of Life Science , Life Science Course

Title

Professor

Research Fields, keywords

neurodegenerative disease, protein aggregation, molecular chaperone

Homepage URL

http://kubotalabakitauniv.tumblr.com/

Academic Background (Undergraduate Level) 【 display / non-display

  • Shizuoka University   Faculty of Science   1985.03  Graduated

Academic Background (Graduate Level) 【 display / non-display

  • Osaka University  Graduate School,Division of Medicine  Doctor's Degree Program  1992.03  Completed

  • Shizuoka University  Graduate School, Division of Natural Science  Master's Degree Program  1987.03  Completed

Professional Career On-Campus 【 display / non-display

  • 2010.11
    -
     

    Akita University   Graduate School of Engineering and Resource Science   Department of Life Science   Professor

  • 2008.04
    -
    2010.10

    Akita University   Graduate School of Engineering and Resource Science   Associate Professor

External Career 【 display / non-display

  • 1992.04
    -
    1995.08

    Institute of Cancer Research   postdoctoral fellow  

Research Field(Grants-in-Aid-for-Scientific-Research classification ) 【 display / non-display

  • Molecular biology

  • Cell biology

 

Articles 【 display / non-display

  • ATPase activity and ATP-dependent conformational change in the co-chaperone HOP.

    Yamamoto, S., Subedi, G.P., Hanashima, S., Satoh, T., Otaka, M., Wakui, H., Sawada, K., Yokota, S., Yamaguchi, Y., Kubota, H., and Itoh, H.

    J. Biol. Chem.   289   9880 - 9886   2014.04

  • Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.

    Kitamura, A., Inada, N., Kubota, H., Matsumoto, G., Kinjo, M., Morimoto, R.I., and Nagata, K.

    Genes Cells   19   209 - 224   2014.03

  • Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation.

    Tashiro, E., Zako, T., Muto, H., Itoo, Y., Sörgjerd, K., Terada, N., Abe, A., Miyazawa, M., Kitamura, A., Kitaura, H., Kubota, H., Maeda, M., Momoi, T., Iguchi-Ariga, S.M., Kinjo, M., and Ariga, H.

    J. Biol. Chem.   288   19958 - 19972   2013.07

  • Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins.

    Oguro, A., Kubota, H., Shimizu, M., Ishiura, S. and Atomi, Y.

    Neurosci. Lett.   503   234 - 239   2011.10

  • Solution structure and dynamics of mouse ARMET.

    Hoseki, J., Sasakawa, H., Yamaguchi, Y., Maeda, M., Kubota, H., Kato, K. and Nagata, K.

    FEBS Lett.   584   1536 - 1542   2010.04

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Reviews 【 display / non-display

  • Analyzing the aggregation of polyglutamine-expansion proteins and its modulation by molecular chaperones.

    Kubota, H., Kitamura, A. and Nagata, K.

    Methods ( Elsevier )   53   267 - 274   2011.03

  • Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus.

    Kitamura, A. and Kubota, H.

    FEBS J. ( Wiley-Blackwell )   277   1369 - 1379   2010.03

  • Quality control against misfolded proteins in the cytosol: a network for cell survival.

    Kubota, H.

    J. Biochem. ( Oxford University Press )   146   609 - 616   2009.11