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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Biochemistry and Metabolic Science |
KOIZUMI Yukio
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Graduating School 【 display / non-display 】
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-1996.03
Nihon University Faculty of Science and Engineering Graduated
Graduate School 【 display / non-display 】
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-2002.03
Tokyo University of Agriculture and Technology Graduate School, Division of Agricltural Sciences Doctor's Course Completed
Campus Career 【 display / non-display 】
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2009.04-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Biochemistry and Metabolic Science Assistant Professor
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2007.04-2009.03
Akita University School of Medicine School of Medicine Assistant Professor
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2004.10-2007.03
Akita University School of Medicine School of Medicine Research Assistant
Academic Society Affiliations 【 display / non-display 】
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2012.03-Now
Japan
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
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2009.07-Now
Japan
SOCIETY FOR ACTINOMYCETES JAPAN
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2002.10-Now
Japan
THE JAPANESE BIOCHEMICAL SOCIETY
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1997.12-Now
Japan
JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
Research Areas 【 display / non-display 】
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Life Science / Environmental and natural pharmaceutical resources
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Life Science / Bioorganic chemistry
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Life Science / Medical biochemistry
Research Achievements 【 display / non-display 】
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Nagaki Y.
Genes to Cells ( Genes to Cells ) 25 ( 8 ) 547 - 561 2020.08 [Refereed]
Research paper (journal)
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Koizumi Y.
ChemBioChem ( ChemBioChem ) 20 ( 12 ) 1563 - 1568 2019.06 [Refereed]
Research paper (journal)
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Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity
Koizumi Y.
Scientific Reports ( Scientific Reports ) 8 ( 1 ) 2018.12 [Refereed]
Research paper (journal)
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The CCR4-NOT deadenylase complex controls atg7-dependent cell death and heart function
Yamaguchi T.
Science Signaling ( Science Signaling ) 11 ( 516 ) 2018.02 [Refereed]
Research paper (journal)
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Analysis for the role of CCR4-NOT complex in regulation of adenine nucleotide metabolism in the hearts
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Miyuki Natsui, Ayumi Kadowaki, Chitose Sato, Yukio Koizumi, Akinori Takahashi, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC ) 130 ( 3 ) S78 - S78 2016.03
Research paper (journal)
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環状ペプチドマルホルミンが賦活化する細胞性血栓溶解にはRSK1の活性化が関与する
小泉幸央, 長井賢一郎, GAO Lina, 山口智和, 夏井美幸, 今井由美子, 蓮見惠司, 杉山俊博, 久場敬司
日本農芸化学会大会講演要旨集(Web) 2018 ROMBUNNO.3A14p01 (WEB ONLY) 2018.03
Summary of the papers read (national conference and other science council)
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Flores Maria Jolina Lou N., Koyota Souichi, Qiao Zhiwei, Koizumi Yukio, Sugiyama Toshihiro
秋田医学 ( 秋田大学 ) 40 ( 3 ) 163 - 173 2014.03 [Refereed]
Aim : Ceruloplasmin (Cp) is an acute-phase protein and a member of the multicopper oxidase family of enzymes. It has been implicated in iron metabolism because of its ferroxidase activity. It is expressed as soluble (sCp) or glycosylphosphatidylinositol-anchored ceruloplasmin (GPI-Cp) form ; the former is primarily synthesized in the liver, and the latter is primarily found in the brain. Although recent studies reported GPI-Cp expression on hepatocytes, little is known regarding its presence in specific liver cell compartments and its possible involvement in liver pathophysiology. This study aimed to characterize the distribution of GPI-Cp in liver cells and specifically in the apical part of the plasma membrane. Methods : We assessed GPI-Cp expression in the liver using immunohistochemistry and immunoblotting techniques. Furthermore, we isolated apical and basolateral membrane fraction from the total liver membrane using sucrose discontinuous gradient centrifugation, and GPI-Cp were detected using immunoblotting. Results : GPI-Cp was detected in purified apical membranes of rat liver cells. Immunoreactive Cp protein was released after incubation with phosphatidylinositol-specific phospholipase C, and the free protein demonstrated ferroxidase activity. Conclusion : These findings suggest that majority of GPI-Cp present in the liver is primarily located on the apical surface of cells because of transcytosis.
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Stimulation of the hair growth by α2-blocker SST-VED
Natsui Miyuki, Kawagoe Masami, Somei Masanori, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro
Akita journal of medicine ( Akita University ) 41 ( 1 ) 23 - 33 2014 [Refereed]
The hair follicle was picked from the beard of a C57BL/6J mouse, and the influence on hair follicle extension was measured by hair follicle organ culture under the addition of SST-VED1. Compared with control( solvent of SST-VED1), the hair growth by SST-VED1 addition was observed in dose-dependent manner. When SST-VED1 was compared with SST-VED2, SST-VED1 promotes the hair growth significantly. Moreover, it turned out that growth is large in order of RiUP^<(R)>, SST-VED1, and Glechoma hederacea extract. In this research, it was shown clearly that new molecular chemicals of SST-VED 1 and 2 have a hair growth action. Furthermore, by using it together with the extract obtained from Glechoma hederacea of product-of-nature origin, it turned out that a hair growth action is amplified.
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Identification of antioxidants derived from Inonotus obliquus
Kumagai Ayako, Koizumi Yukio, Kawagoe Masami, Koyota Souichi, Sugiyama Toshihiro
Akita journal of medicine ( Akita University ) 40 ( 2 ) 113 - 119 2013 [Refereed]
The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. In the present study, the lipophilic fraction of Inonotus obliquus were investigated for their antioxidative activity with hydroxyl radical scavenging activity assays. As a result, two acidic materials had higher antioxidative activity than basic or neutral materials. Furthermore, antioxidative acidic materials including organic acids were isolated by silica gel column chromatography and subsequent preparative high-performance liquid chromatography. Two purified antioxidants, designated compound 1 and 2, were identified as vanillic acid and syringic acid, respectively. Vanillic acid and syringic acid were showed the antioxidative activities with IC_50 values of 59.0 and 2.8 μg/ml, respectively.
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Sitmulation of the hair growth by a natural origin Glechoma hederacea extract
Natsui Miyuki, Kawagoe Masami, Nagai Shigeharu, Qiao Zhiwei, Sato Yoshiaki, Flores Maria Jolina, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro
Akita journal of medicine ( Akita University ) 40 ( 1 ) 1 - 12 2013 [Refereed]
The glechoma hederacea subsp. grandis( G. grandis) is used as an herbal medicine and is supposed that the extract at the time of the bloom shade-drying is effective against a child's convulsion. Moreover, it may be considered as reduction of blood sugar level. In this study, the clinical test of the hair growth facilitatory effect of the G. grandis extract in human during one to three years showed remarkable improvement or a little improvement by evaluation at 95%(41 persons among 43 persons). With the mice, the tendency for hair growth was promoted compared with a control( physiological saline). Furthermore, we used the hair follicle organ culture system for the hair growth promoting substance from G. grandis extract. As a result, G. grandis in the growth phase after the bloom had remarkable growth effect, and found out having the remarkable hair growth effect in a fraction of aqueous phase from the extract especially. This aims at the establishment of the hair regenerative technology which utilizes the natural plant, G. grandis. It is possible to apply to the baldness and the alopecia caused by various factors, and preventive effect for the depilation, trichogenous, and the hair restoration action improve synergistic and it is effective as the external application medicine for the head with high safety compared with the scalp.
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Exploration and evaluation of low molecular weight thrombolytic agents that induce endogenous uPA expression
Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2014.04 - 2017.03 Investigator(s): KOIZUMI Yukio
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Grant-in-Aid for Scientific Research(C)
Project Year： 2014.04 - 2017.03 Investigator(s): KOIZUMI Yukio
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Grant-in-Aid for Young Scientists(B)
Project Year： 2012.04 - 2015.03 Investigator(s): KOIZUMI Yukio
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Grant-in-Aid for Young Scientists(B)
Project Year： 2012.04 - 2015.03 Investigator(s): KOIZUMI Yukio