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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Gastroenterological Surgery |
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Laboratory Address |
1-1-1, Hondo, Akita, 010-8543, Japan |
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Homepage URL |
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Mail Address |
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ARITA Junichi
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Research Interests 【 display / non-display 】
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Biliary tract
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Liver
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Rectum
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Colon
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Stomach
Graduating School 【 display / non-display 】
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1991.04-1997.03
The University of Tokyo Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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2003.04-2007.03
The University of Tokyo Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2022.10-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Gastroenterological Surgery Professor
Thesis for a degree 【 display / non-display 】
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Randomized clinical trial of the effect of a saline-linked radiofrequency coagulator on blood loss during hepatic resection
2007.03 [Refereed]
Single author
Research Achievements 【 display / non-display 】
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Closure and anastomosis of the pancreas using a four-needle three-loop suture device
Ishizawa Takeaki, Akamatsu Nobuhisa, Kaneko Junichi, Arita Junichi, Hasegawa Kiyoshi
Global Health & Medicine ( 国立研究開発法人 国立国際医療研究センター ) 4 ( 4 ) 225 - 229 2022.08
<p>Pancreatic juice can leak not only from the main pancreatic duct but also from unclosed ductal branches appearing on the pancreatic stump. We have developed a suture device consisting of three loops of suture attached to four small-curvature needles with the aim to maximize the area of pancreatic parenchyma to be ligated and reduce the number of punctures made on the pancreas during pancreatic closure or anastomosis. In pancreatojejunostomy, the dorsal wall of the jejunum and then the pancreatic parenchyma are sutured using the four needles. Following duct-to-mucosa anastomosis, the ventral jejunal wall is sutured, and the three threads are finally tied sequentially to complete the reconstruction following the Blumgart method. In distal pancreatectomy, the pancreatic stump is sutured from the dorsal aspect sequentially using the four needles, before or after the pancreatic transection. The three threads are then respectively tied on the ventral surface of the pancreas. This device was used in six pancreatoduodenectomies (including two minimally invasive procedures) and five distal pancreatectomies. A postoperative pancreatic fistula requiring additional drainage or repositioning of abdominal drains developed in two patients. No adverse events associated with this device were encountered. The four-needle three-loop suture device can be an alternative to conventional staplers or sutures for closure and anastomosis of the pancreatic stump. </p>
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A Case of Resected Mixed Acinar-neuroendocrine Carcinoma with Synchronous Liver Metastases
KAWAGUCHI Yoshikuni, YOSHIZAKI Yuhi, TANAKA Mariko, ARITA Junichi, USHIKU Tetsuo, HASEGAWA Kiyoshi
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ( Japan Surgical Association ) 83 ( 4 ) 755 - 761 2022
<p>A 69-year-old man presented with upper abdominal pain. Computed tomography showed a tumor located at the pancreatic head and two liver tumors suggestive of metastases. The pancreas tumor invaded the duodenum and showed tumor thrombus in the superior mesenteric vein. He was diagnosed with pancreatic neuroendocrine carcinoma based on the histopathological examination of the biopsy samples. In the course of chemotherapy with the regimen of irinotecan and cisplatin elsewhere, he visited our hospital to ask for a second opinion. Histopathological rediagnosis at our hospital revealed that the tumor was pancreatic neuroendocrine tumor grade 3 from the classification of WHO 2019. Since the Clinical Practice Guidelines for Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN) 2019 in Japan recommend multidisciplinary therapy including resection of neuroendocrine tumor and synchronous liver metastases, he underwent pancreaticoduodenectomy with removal of portal vein/superior mesenteric vein tumor thrombus, and two limited resections of the liver. The pathological diagnosis was mixed acinar-neuroendocrine carcinoma. He underwent adjuvant chemotherapy and has been recurrence free as of 15 months after the surgery. Our experience with the case is informative in clinical practice because clinical managements of pancreatic tumor with synchronous liver metastasis differ depending on its pathological diagnosis.</p>
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SAITO Kei, NAKAI Yousuke, ARITA Junichi, ISHIGAKI Kazunaga, TAKAHARA Naminatsu, ISHIZAWA Takeaki, WATADANI Takeyuki, HASEGAWA Kiyoshi, KOIKE Kazuhiko
Suizo ( Japan Pancreas Society ) 36 ( 1 ) 29 - 35 2021.02
<p>There has been a pressing need to develop the optimal regimen for neoadjuvant chemotherapy (NAC) for patients with pancreatic cancer (PC). Recently, surgical resection after neoadjuvant gemcitabine plus S-1 (GS) compared with upfront surgery in patients with resectable PC, showed significantly better overall survival in the Prep-02/JSAP05 study. We conducted a retrospective analysis of patients with resectable T3 PC who underwent neoadjuvant GS to evaluate the safety and effectiveness of neoadjuvant GS in a real-world setting. A total of 22 patients received neoadjuvant GS between July 2019 and June 2020. Major Grade 3-4 toxicities included neutropenia (55%), thrombocytopenia (9.1%), oral stomatitis (9.1%) and skin rash (4.5%). The reasons for treatment failure were unacceptable toxicities in 4 patients. The resection rate was 100% and R0 resection rate was 96%. Neoadjuvant GS in patients with resectable T3 PC may increase the chance for curative resection, but it is important to prevent and mange adverse events appropriately.</p>
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Simulation and navigation liver surgery: an update after 2,000 virtual hepatectomies
Miyata Akinori, Arita Junichi, Kawaguchi Yoshikuni, Hasegawa Kiyoshi, Kokudo Norihiro
Global Health & Medicine ( 国立研究開発法人 国立国際医療研究センター ) 2 ( 5 ) 298 - 305 2020.10
<p>The advent of preoperative 3-dimensional (3D) simulation software has made a variety of unprecedented surgical simulations possible. Since 2004, we have performed more than 2,000 preoperative simulations in the University of Tokyo Hospital, and they have enabled us to obtain a great deal of information, such as the detailed shape of liver segments, the precise volume of each segment, and the volume of hepatic venous drainage areas. As a result, we have been able to perform more aggressive and complicated surgery safely. The next step is to create a navigation system that will accurately reproduce the preoperative plan. Real-time virtual sonography (RVS) is a navigation system that provides fusion images of ultrasonography and reconstructed computed tomography images or magnetic resonance images. The RVS system facilitates the surgeon's understanding of interpretation of ultrasound images and the detection of tumors that are difficult to find by ultrasound alone. In the near future, surgical navigation systems may evolve to the point where they will be able to inform surgeons intraoperatively in real time about not only intrahepatic structures, such as vessels and tumors, but also the portal territory, hepatic vein drainage areas, and resection lines that have been planned preoperatively.</p>
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A case of successful surgical treatment for splenic arteriovenous fistula
Furukawa S, Kaneko J, Akamatsu N, Ichida A, Ishizawa T, Arita J, Hasegawa K
Japanese Journal of Portal Hypertension ( The Japan Society for Portal Hypertension ) 26 ( 1 ) 47 - 52 2020