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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Anesthesia and Intensive Care Medicine |
NIYAMA Yukitoshi
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Graduating School 【 display / non-display 】
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-1998.03
Sapporo Medical University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2007.03
Sapporo Medical University Graduate School,Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2020.02-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Professor
Research Areas 【 display / non-display 】
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Life Science / Anesthesiology
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Life Science / Pathophysiologic neuroscience
Thesis for a degree 【 display / non-display 】
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The impact of air transport for acute coronary syndrome patients.
Homma H, Niiyama Y, Sonoda H, Himuro N, Yamakage M
2019.03
Domestic Co-author
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Propofol target controlled infusion in obese Japanese patients: Evaluation of bias for predicted and measured concentrations. An open-label comparative study.
Tachibana N, Niiyama Y, Yamakage M
2014.03
Domestic Co-author
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Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice.
Sawada A, Niiyama Y, Ataka K, Nagaishi K, Yamakage M, Fujimiya M
2014.03
Domestic Co-author
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Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain.
Yamamoto J, Kawamata T, Niiyama Y, Omote K, Namiki A
2014.03
Domestic Co-author
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Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
Furuse S, Kawamata T, Yamamoto J, Niiyama Y, Omote K, Watanabe M, Namiki A
2009.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Influence of Different Sevoflurane Concentrations on Postoperative Cognitive Function in Aged Rats.
Natsuko Yamamoto, Tetsu Kimura, Yukitoshi Niiyama
Anesthesia and analgesia 136 ( 4 ) 772 - 778 2023.04
Research paper (journal)
BACKGROUND: Postoperative cognitive dysfunction may be associated with neuroinflammation, and sevoflurane suppresses surgery-induced inflammation. We hypothesized that low concentrations of sevoflurane would result in more impaired postoperative cognitive function compared to high concentrations. METHODS: Aged male Sprague-Dawley rats (n = 21, 17-22 months) were randomly assigned to 1 of 3 groups: control (C), sevoflurane 2% (S2), and sevoflurane 4% (S4). Rats in the S2 and S4 groups underwent open femoral fracture and intramedullary fixation of the left hind limb under 2 hours of sevoflurane anesthesia. Neurological outcomes were evaluated using the Morris water maze (MWM) test, and histopathological outcomes were assessed 28 days after surgery. RESULTS: The S2 group showed prolonged swimming latency compared to S4 on day 7 (difference of means, 34.4; 95% confidence interval [CI], 2.57-66.3; P = .031) and compared to the C group on day 9 (difference of means, -33.4; 95% CI, -65.3 to -1.55; P = .037). The intact CA1 cells in the S2 group were significantly less than those in the C and S4 groups (H statistic, 10.87; P = .006 versus C; P = .033 versus S4). CONCLUSIONS: We found that low concentrations of sevoflurane prolonged the swimming latency of the MWM compared to high concentrations and reduced intact CA1 hippocampal neurons in aged rats. These results suggest that low-concentration sevoflurane anesthesia may be more detrimental than high concentration for spatial cognitive function and postoperative impairment of hippocampal CA1 cells in aged rats.
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Less postoperative sore throat after nasotracheal intubation using a fiberoptic bronchoscope than using a Macintosh laryngoscope: A double-blind, randomized, controlled study.
Tachibana N, Niiyama Y, Yamakage M
J Clin Anesth 2017.06
Research paper (journal) Domestic Co-author
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Continuous wound infiltration with 0.2% ropivacaine versus a single intercostal nerve block with 0.75% ropivacaine for postoperative pain management after reconstructive surgery for microtia.
Niiyama Y, Yotsuyanagi T, Yamakage M
J Plast Reconstr Aesthet Surg 2016.10
Research paper (journal) Domestic Co-author
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Incidence of cannot intubate-cannot ventilate (CICV): results of a 3-year retrospective multicenter clinical study in a network of university hospitals.
Tachibana N, Niiyama Y, Yamakage M
J Anesth 2015.06
Research paper (journal) Domestic Co-author
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Involvement of transient receptor potential vanilloid subfamily 1 in endothelin-1-induced pain-like behavior.
Kawamata T, Ji W, Yamamoto J, Niiyama Y, Furuse S, Omote K, Namiki A
Neuroreport 2009.02
Research paper (journal) Domestic Co-author
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A Case of Tracheobronchopathia Osteochondroplastica Discovered Accidentally by Difficult Intubation
KONNO Toshihiro, KODAMA Sahoko, KIMURA Tetsu, NIIYAMA Yukitoshi
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA ( THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA ) 41 ( 2 ) 152 - 155 2021
<p>We experienced a case of Tracheobronchopathia Osteochondroplastica(TO)discovered by difficult tracheal intubation during general anesthesia. A 66 year-old woman was diagnosed with acute appendicitis, and underwent emergency surgery under general anesthesia. Mask ventilation was easily performed after induction of anesthesia. Despite Cormack-Lehane grade I with direct laryngoscopy, the end-tracheal tube with an internal diameter(ID)of 7.0 mm could not pass through the glottis because of friction beneath the glottis. After confirming mask ventilation, we re-assessed the airway with computed tomography images. Several protrusions from the anterior part of the tracheal wall seemed to disrupt tracheal intubation. Finally, the trachea was successfully intubated with the thinner tube(ID 6.0 mm), rotating the bevel toward the posterior wall of the trachea after passing the glottis.</p><p>Because TO often progresses asymptomatically, patients with TO may undergo general anesthesia without a diagnosis. Although TO is one cause of difficult intubation, patients can be managed safely.</p>
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2023.04 - 2027.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
Presentations 【 display / non-display 】
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Effects of gender, age, and body mass undex on sedation level during infusion of propofol by target-controlled infusion.
Niiyama Y, Omote K, Kawamata T, Namiki A
米国麻酔科学会 2002.10 - 2002.10