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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Neuropsychiatry |
IMANISHI Aya
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Graduating School 【 display / non-display 】
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1998.04-2004.03
Kumamoto University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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2015.04-2019.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2019.07-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Psychiatry / 睡眠医学
Thesis for a degree 【 display / non-display 】
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HPVワクチン摂取後の過眠症患者の脳脊髄液中オレキシン濃度は正常である
Aya Imanishi MD, Takashi Kanbayashi MD, PhD, Yohei Sagawa MD, PhD, Yudai Taniguchi MD, Akari Usumoto MD, Kotaro Yuge MD, Nozomu Kotorii MD, PhD, Tomomi Kinoshita MD, PhD, Toshiaki Hirai MD, PhD, Yuki Omori MD, PhD, Kazuhisa Yoshizawa MD, Tetsuo Shimizu MD, PhD
Sleep and Biological Rhythms 17 259 - 261 2019.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Kamada Y.
Sleep Medicine ( Sleep Medicine ) 114 119 - 127 2024.02 [Refereed]
Research paper (journal)
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Ishido H.
BMJ Neurology Open ( BMJ Neurology Open ) 5 ( 1 ) 2023.06 [Refereed]
Research paper (journal)
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Imanishi A.
Sleep and Biological Rhythms ( Sleep and Biological Rhythms ) 21 ( 1 ) 2023.01 [Refereed]
Research paper (journal)
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Exploratory Validation of Sleep-Tracking Devices in Patients with Psychiatric Disorders
Ogasawara M.
Nature and Science of Sleep ( Nature and Science of Sleep ) 15 301 - 312 2023 [Refereed]
Research paper (journal)
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Association of hypersomnolence and neurodevelopmental disorders (ADHD/ASD) and their treatment (Are the increases in neurodevelopmental diseases with hypersomnolence caused by infection of H1N1 influenza?)
Kanbayashi Takashi, Imanishi Aya, Tominaga Morie, Ishido Hideaki, Irukayama Yoko, Han GoEun, Kimura Mayumi, Kondo Hideaki
Neurological Therapeutics ( Japanese Society of Neurological Therapeutics ) 38 ( 4 ) 503 - 507 2021
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Effects of aripiprazole for prolonged nocturnal sleep and delayed sleep phase disorder
Kanbayashi Takashi, Shimizu Tetsuo, Omori Yuki, Imanishi Aya, Takaki Manabu, Sagawa Youhei, Tsutsui Ko, Takeshima Masahiro, Ono Taisuke, Shiomi Toshiaki
Neurological Therapeutics ( Japanese Society of Neurological Therapeutics ) 34 ( 4 ) 406 - 410 2018
<p>Delayed sleep phase disorder (DSPD) comprises a persistent or recurrent pattern of sleep disturbances, sleep disruption that leads to insomnia and/or excessive daytime sleepiness, and impaired functioning in social, occupational, or other spheres. Three techniques are typically used to treat DSPD : chronotherapy, phototherapy, and exogenous melatonin administration. Antipsychotics have not been reported in the treatment of DSPD, aripiprazole (APZ), which is a second generation antipsychotic, manifests a novel mechanism of action by serving as a partial agonist of D2 receptors. Depression is reported to be the most common psychopathology associated with DSPD, and APZ is reported to be effective in major depressive disorder as adjunctive therapy. Therefore, we speculated that APZ might be effective to treat DSPD, and we observed how APZ works for the treatment of DSPD.</p><p>Methods : 18 subjects (including 7 women) who are 14–48–year–old (the average is 31.6) were included. The patients were prescribed 0.75–4.5mg APZ at once a day.</p><p>Results : We prescribed 1.5–3.0mg/day of APZ, all subject reduced total sleep time (9.6 +/− 2.3h → 7.8 +/− 2.0h, p=0.03), many cases got up earlier (9.1 +/− 1.9h → 6.7 +/− 1.4h, p=0.005) in the morning and advanced their sleep phase within one week. The sleep onset was not significantly changed (23.5 +/− 2.0h → 22.9 +/− 1.9h, n.s.).</p><p>Conclusion : Low dose of APZ would reduce nocturnal sleep time in the subjects who had prolonged sleep time and DSPD symptoms. The mechanism of action would be dopaminergic up regulation due to dopamine D3 agonistic activity. Since it is difficult for physicians to treat prolonged sleep time and DSPD symptoms, this medication would become a new therapeutic tool for these patients.</p>
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Effects of aripiprazole for prolonged nocturnal sleep and delayed sleep phase disorder
Kanbayashi Takashi, Omori Yuki, Imanishi Aya, Takaki Manabu, Sagawa Youhei, Tsutsui Ko, Takeshima Masahiro, Ono Taisuke, Shiomi Toshiaki, Shimizu Tetsuo
Neurological Therapeutics ( Japanese Society of Neurological Therapeutics ) 34 ( 4 ) 406 - 410 2018