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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Gastroenterology and Neurology |
SHIMODAIRA Yousuke
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Graduating School 【 display / non-display 】
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-2007.03
Tohoku University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2014.03
Tohoku University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2019.01-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Assistant Professor
Research Achievements 【 display / non-display 】
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Direct signaling ofTL1A‑DR3 on fbroblasts induces intestinal fbrosis in vivo
Noam Jacob, Kotaro Kumagai , Jay P.Abraham , Yosuke Shimodaira , YuefangYe , Justin Luu , AnnaY. Blackwood , Sof L. Castanon , DaltonT. Stamps , Lisa S.Thomas , RivkahGonsky , David Q. Shih , Kathrin S. Michelsen & Stephan R.Targan
Scientific Reports 2020.10 [Refereed]
Research paper (journal) International Co-author
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Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute,Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li,Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo,Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih,Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm,Marcel R. de Zoete, C. Janneke van der Woude, Guo-Cheng Yuan,Kai W. Wucherpfennig, Stephan R. Targan, Philip Rosenstiel,Richard A. Flavell, Kathy D. McCoy, Andrew J. Macpherson,Arthur Kaser, Richard S. Blumberg
SCIENCE 2019.03 [Refereed]
Research paper (journal) International Co-author
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MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Seiichi Takahashi, Yoshitaka Kinouchi, and Tooru Shimosegawa
World Journal of Gastrointestinal Oncology 2016.07 [Refereed]
Research paper (journal) International Co-author
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Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells
Yosuke Shimodaira, Seiichi Takahashi, Yoshitaka Kinouchi, Katsuya Endo, Hisashi Shiga, Yoichi Kakuta, Masatake Kuroha, Tooru Shimosegawa
Biochemical and Biophysical Research Communications 2014.02 [Refereed]
Research paper (journal) International Co-author
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FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn’s disease through affecting the ADCC activity
Rintaro Moroi, Katsuya Endo, Yoshitaka Kinouchi, Hisashi Shiga, Yoichi Kakuta, Masatake Kuroha, Yoshitake Kanazawa, Yosuke Shimodaira, Takahiko Horiuchi, Seiichi Takahashi & Tooru Shimosegawa
Immunogenetics 2013.01 [Refereed]
Research paper (journal) International Co-author
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Intestinal infections and systemic diseases by PPI-induced alterations in gut microbiota.
2023.01
Introduction and explanation (scientific journal) Single author
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Analysis of the role of the endoplasmic reticulum stress response-related molecule CHOP in intestinal epithelial cells
Shimodaira, Yosuke
Impact 2021.07
Introduction and explanation (others) Single author
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VI. Intestinal Infections and Systemic Diseases by PPI-induced Alterations in Gut Microbiota
Shimodaira Yosuke, Iijima Katsunori
Nihon Naika Gakkai Zasshi ( The Japanese Society of Internal Medicine ) 112 ( 1 ) 45 - 50 2023.01
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A case of severe inflammatory bowel disease triggered by vaccination with SARS-CoV-2 mRNA
TAKAHASHI Yasutaka, SHIMODAIRA Yosuke, YOSHIDA Tatsuki, TAJIKA Munehiko, TAKAHASHI So, WATANABE Kenta, FUKUDA Sho, KOIZUMI Shigeto, MATSUHASHI Tamotsu, IIJIMA Katsunori
Nippon Shokakibyo Gakkai Zasshi ( The Japanese Society of Gastroenterology ) 120 ( 4 ) 325 - 329 2023
<p>A 64-year-old woman received a third dose of SARS-CoV-2 mRNA vaccine. On the next day, she developed fever, diarrhea, and abdominal pain and had bloody stools. Total colonoscopy revealed deep ulceration on the whole colon. She was treated with corticosteroid and infliximab and her symptoms improved. She was diagnosed with severe enteritis resembling ulcerative colitis triggered by SARS-CoV-2 mRNA vaccination.</p>
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2020.04 - 2022.03
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Grant-in-Aid for Research Activity start-up
Project Year： 2019.04 - 2021.03
Presentations 【 display / non-display 】
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The role of TL1A-DR3 system in intestinal epithelial cells
Yosuke Shimodaira
Annual Meeting of the Japanese Society for Immunology 2021.12 - 2021.12
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TL1A-DR3 system in naive T cells leads TH1 differentiation
Yosuke Shimodaira
JDDW 2019.11 - 2019.11
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NOVEL ROLE FOR DEATH RECEPTOR 3 (DR3) EXPRESSED ON INTESTINAL EPITHELIAL CELLS IN REGULATING HOMEOSTATIC INTESTINAL PERMEABILITY AND EPITHELIAL CELL PROLIFERATION, AS WELL AS REGENERATION AFTER INTESTINAL MUCOSAL INJURY
Yosuke Shimodaira, Jay P. Abraham, Hussein Hamade, Anna Y. Blackwood, Lisa S. Thomas, Sofi L. Castanon, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen
DDW 2019.05 - 2019.05
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TL1A-deficiency (but not DR3-deficiency) protects from the development of colitis in the chronic T cell transfer mouse model by decreasing TH1 cell accumulation in the intestinal mucosa
Shimodaira Y, Kanazawa Y, Abraham J, Kumagai K, Jacob N, Ye Y, Luu J, Blackwood A, Michelsen K, Targan S, Shih D
DDW 2018.06 - 2018.06