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Affiliation |
Hospital SurgeryⅡ |
Graduating School 【 display / non-display 】
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-2008.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2015.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2016.04-Now
Akita University Hospital SurgeryⅡ Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Digestive surgery / 食道外科
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Life Science / Digestive surgery / Esophageal surgery
Thesis for a degree 【 display / non-display 】
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REG Iαactivates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells
Wakita A, Motoyama S (Corresponding author), Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y
Tumor Biol 2015.04 [Refereed]
Single author
Research Achievements 【 display / non-display 】
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Motoyama S.
Anticancer Research ( Anticancer Research ) 42 ( 12 ) 6105 - 6112 2022.12 [Refereed]
Research paper (journal)
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Changes in Serum Trace Element Concentrations before and after Surgery in Resectable Breast Cancer
Takahashi E.
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5323 - 5334 2022.11 [Refereed]
Research paper (journal)
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Motoyama S.
Annals of Surgery ( Annals of Surgery ) 276 ( 1 ) E16 - E23 2022.07 [Refereed]
Research paper (journal)
OBJECTIVE: To determine whether esophagectomy provides a survival advantage in octogenarians with resectable thoracic esophageal cancer. SUMMARY BACKGROUND DATA: Elderly patients with thoracic esophageal cancer do not always receive the full standard treatment; however, advanced age alone should not preclude the use of effective treatment that could meaningfully improve survival. METHODS: We retrieved the 2008 to 2011 data from the National Database of Hospital-based Cancer Registries from the National Cancer Centerin Japan, divided the patients into a ≥75 group (75-79 years; n = 2935) and a ≥80 group (80 years or older; n = 2131), and then compared the patient backgrounds and survival curves. A multivariable Cox proportional hazards regression model was developed to compare the effects of esophagectomy and chemoradiotherapy in the 2 groups. RESULTS: A significantly greater percentage of patients were treated with esoph-agectomy in the ≥75 group (34.6%) than the ≥80 group (18.4%). Among patients who received esophagectomy, the 3-year survival rate was 51.1% in the ≥ 75 group and 39.0% in the ≥80 group (P < 0.001). However, among patients who received chemoradiotherapy, there was no difference in survival curve between the 2 groups (P = 0.17). Multivariable Cox proportional hazard analysis revealed that esoph-agectomy for clinical Stage ii-iii patients was significantly associated to better survival (adjusted HR: 0.731) (95%CI: 0.645-0.829, P < 0.001) in the ≥75 group but not the ≥ 80 group when compared with chemoradiotherapy. CONCLUSIONS: Many octogenarians do not necessarily get a survival benefit from esophagectomy. However, patients should be evaluated based on their overall health before ruling out surgery based on age alone.
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Fujita K.
Esophagus ( Esophagus ) 19 ( 1 ) 146 - 152 2022.01 [Refereed]
Research paper (journal)
BACKGROUND: Platinum agents are taken up into cells by copper transporter (CTR) 1 (gene code: SLC31A1) and are excreted from cells by copper-transporting P-type adenosine triphosphatase (ATP7B) and multidrug resistance-associated protein (MRP) 2 (gene code: ABCC2). In addition, glutathione S transferase (GST) P1 is involved in the metabolism of platinum agents. The present study aimed to determine whether the rate of grade 3-4 hematological toxicity associated with platinum plus 5-fluorouracil (5-FU) therapy in 239 patients with esophageal cancer was affected by the SLC31A1 rs10981694A>C and rs12686377G>T, ATP7B rs9535828A>G, GSTP1 rs1695A>G, and ABCC2 -24C>T polymorphisms. METHODS: Chemotherapy consisted of protracted infusion of 5-FU (800 mg/m2/day) on days 1-5 and cisplatin or nedaplatin (80 mg/m2/day) on day 1. RESULTS: A total of 82 of 239 patients developed grade 3-4 hematological toxicity after chemotherapy. Univariate analysis showed that ABCC2 -24C/T + T/T genotypes (P = 0.038), radiation therapy (P = 0.013), baseline white blood cell count < 6000/μL (P = 0.003), and baseline neutrophil count < 3900/μL (P = 0.021) were statistically significant predictors of grade 3-4 hematological toxicity. Multivariate analysis revealed that ABCC2 -24C/T + T/T genotypes (P = 0.036), radiation therapy (P = 0.005), and baseline white blood cell count < 6000/μL (P < 0.001) were significant risk factors. CONCLUSIONS: We determined that ABCC2 -24C>T is significantly associated with grade 3-4 hematological toxicity after platinum plus 5-FU therapy. These findings might contribute to improved treatment strategies for patients with esophageal cancer.
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Fujita H.
Surgery (United States) ( Surgery (United States) ) 171 ( 6 ) 1535 - 1542 2022 [Refereed]
Research paper (journal)
BackgroundThe mechanism underlying cancer cell metastasis from the tumor to regional lymph nodes is not yet fully understood. We hypothesized that peritumoral neutrophil accumulation promotes regional lymph node metastasis in thoracic esophageal squamous cell cancer.MethodsBetween 2010 and 2019, 126 thoracic esophageal squamous cell cancer patients received curative (R0) esophagectomy without preoperative treatment in our hospital. Using paraffin-embedded resected tumors, we performed immunohistochemical analysis of CD16b-positive neutrophil accumulation in the peritumoral area, which was defined as a 1-mm region centered on the border separating the malignant cell nests from the host tissue. The relationship between the density of peritumoral CD16b staining and pathological lymph node metastasis or 5-year overall survival was evaluated.ResultsAlthough the clinicopathological characteristics of CD16b-high and CD16b-low patients did not differ, greater pathological lymph node metastasis (P < .001) and lymphatic invasion by the tumor (P = .024) and a poorer 5-year survival (P = .010) were seen in CD16b-high patients. Moreover, CD16b-positive neutrophil density was generally higher in the peritumoral area than within the tumor itself. Univariate and multivariate analyses showed that CD16b-positive neutrophil accumulation was an independent factor for lymph node metastasis with an odds ratio >25 (P < .001). On the other hand, blood neutrophil counts did not correlate with lymph node metastasis.
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A male with primary accessory breast carcinoma in an axilla is strongly suspected of having hereditary breast cancer.
Eriko Takahashi, Kaori Terata, Hiroshi Nanjo, Koichi Ishiyama, Yuko Hiroshima, Ayuko Yamaguchi, Misako Yatsuyanagi, Chiaki Kudo, Akiyuki Wakita, Shinogu Takashima, Yusuke Sato, Kazuhiro Imai, Satoru Motoyama, Yoshihiro Minamiya
International cancer conference journal 10 ( 2 ) 107 - 111 2021.04
We herein report on a male with primary accessory breast cancer in an axilla. A 75-year-old man first noticed a subcutaneous nodule about 2 cm in diameter in the area of his right axilla. The patient underwent extirpation of the mass in a public hospital. Histological examination revealed invasive breast carcinoma of no special type associated with mucinous carcinoma, invasive micropapillary carcinoma and intraductal components. Immunohistochemical analysis showed that the tumor cells were positive for Gross cystic disease fluid protein (GCDFP)-15, mammaglobin and GATA3. Staining for estrogen receptor (ER) and progesterone receptor (PR) was positive, and human epidermal growth factor receptor 2 (HER2) was negative. The Ki67 labeling index (LI) was 33.6%. Imaging revealed no evidence of a primary tumor in any other organ or in the bilateral mammary gland. We performed radical resection of the right axilla, including the scar, and axillary lymph node dissection. The final pathological examination of the surgical specimen showed normal mammary gland tissue that was not connected to the proper mammary gland, and no residual cancer or metastatic lymph nodes. Based on our clinical and pathological findings, this tumor was diagnosed as breast cancer originating from the accessory mammary gland in the right axilla. After surgery, tamoxifen was administered as adjuvant therapy. Since the surgery, 2 years ago, there has been no evidence of recurrence. Hereditary Breast and Ovarian Cancer syndrome was suspected in this case because the patient was a male with breast cancer, and he had two first-degree relatives with breast cancer. This patient had no BRCA mutations on genetic testing. Nonetheless, in cases of male breast cancer, it is necessary to obtain genetic information due to the possibility of hereditary breast cancer, including cancers associated with BRCA gene mutation.
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - Now
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Grant-in-Aid for Early-Career Scientists
Project Year： 2018.04 - 2023.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2018.04 - Now Investigator(s): Akiyuki Wakita
Presentations 【 display / non-display 】
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Role of preoperative neoadjuvant chemoradiotherapy for locally advanced borderline resectable thoracic esophageal cancer
Akiyuki Wakita, Motoyama Satoru, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya
18th ISDE World Congress for Esophageal Diseases 2022.09 - 2022.09
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Optimal reconstruction method for McKeown esophagectomy
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya.
第77 回日本消化器外科学会総会 2022.07 - 2022.07
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Evaluation of the benefits of robot-assisted surgery for thoracic esophageal cancer
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Yushi Nagaki, Hiromu Fujita, Kohei Kemuriyama, Yoshihiro Sasaki, Yoshihiro Minamiya
第76回日本消化器外科学会総会 2021.07 - 2021.07
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Therapeutic results of robot-assisted surgery for esophageal cancer and esophagogastric junction cancer
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Yushi Nagaki, Hiromu Fujita, Yoshihiro Minamiya.
第28回日本消化器関連学会週間 2020.11 - 2020.11
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Evaluation of lymph node metastasis of cN0 esophageal cancer patients
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Yuta Kawakita, Yushi Nagaki, Yoshihiro Minamiya.
第73回日本消化器外科学会総会 2018.07 - 2018.07