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Affiliation |
Hospital Urology |
Research Interests 【 display / non-display 】
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泌尿器腹腔鏡手術
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腎移植
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泌尿器科腫瘍
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癌幹細胞
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分子標的療法
Graduating School 【 display / non-display 】
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-2001.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2006.03
Akita University Graduate School,Division of Medicine Doctor's Course Completed
Studying abroad experiences 【 display / non-display 】
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2014.03-2016.02
Brigham and Women's Hospital, Harvard Medical School Psto-doctoral research fellow
Campus Career 【 display / non-display 】
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2020.05-Now
Akita University Hospital Urology Lecturer
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2012.04-2020.04
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Assistant Professor
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2009.04-2012.03
Akita University Hospital Urology Medical Staff
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2004.10-2005.05
Akita University Hospital Urology Medical Staff
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2003.04-2003.10
Akita University Hospital Urology Medical Staff
Thesis for a degree 【 display / non-display 】
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Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus.
Numakura K, Satoh S, Tsuchiya N, Horikawa Y, Inoue T, Kakinuma H, Matsuura S, Saito M, Tada H, Suzuki T, Habuchi T.
Transplantation. 2006.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Avelumab plus axitinib vs sunitinib for advanced renal cell carcinoma: Japanese subgroup analysis from JAVELIN Renal 101.
Uemura M, Tomita Y, Miyake H, Hatakeyama S, Kanayama HO, Numakura K, Takagi T, Kato T, Eto M, Obara W, Uemura H, Choueiri TK, Motzer RJ, Fujii Y, Kamei Y, Umeyama Y, di Pietro A, Oya M.
Cancer Science 2019.12
Research paper (journal) Domestic Co-author
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Impact of persistent preformed and de novo donor-specific antibodies detected at 1 year after kidney transplantation on long-term graft survival in Japan: a retrospective study.
Fujiyama N, Satoh S, Saito M, Numakura K, Inoue T, Yamamoto R, Saito T, Kanda S, Narita S, Mitobe Y, Habuchi T.
Clin Exp Nephrol. 2019.12 [Refereed]
Research paper (journal) Domestic Co-author
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Association of immunosuppressive agents and cytomegalovirus infection with de novo donor-specific antibody development within 1 year after renal transplantation.
Fujiyama N, Satoh S, Saito M, Numakura K, Inoue T, Yamamoto R, Saito T, Nara T, Kanda S, Narita S, Kagaya H, Miura M, Habuchi T.
Int Immunopharmacol. 2019.11
Research paper (journal) Domestic Co-author
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Validation of the IMDC Prognostic Model in Patients With Metastatic Renal-Cell Carcinoma Treated With First-Line Axitinib: A Multicenter Retrospective Study.
Konishi S, Hatakeyama S, Numakura K, Narita S, Inoue T, Saito M, Tokui N, Yamamoto H, Yoneyama T, Hashimoto Y, Yoshikawa K, Narita S, Kawaguchi T, Habuchi T, Ohyama C.
Clin Genitourin Cancer. 2019.11 [Refereed]
Research paper (journal) Domestic Co-author
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Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion.
Nara T, Kanda S, Saito M, Narita S, Inoue T, Habuchi T.
Front Endocrinol (Lausanne). 2019.08 [Refereed]
Research paper (journal) Domestic Co-author
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A Case of Renal Anastomosing Hemangioma
SASAKI Yoshiki, KASHIMA Soki, KOYAMA Takashi, HIROSHIMA Yuko, AMANO Kenji, TAKAHASHI Syuhei, NARA Taketoshi, KOIZUMI Atsushi, YAMAMOTO Ryohei, NUMAKURA Kazuyuki, SAITO Mitsuru, NARITA Shintaro, NANJO Hiroshi, SATOH Shigeru, HABUCHI Tomonori
68 ( 8 ) 265 - 269 2022.08
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Robot-assisted laparoscopic surgery for retroperitoneal and pelvic endocrine tumors
Nara Taketoshi, Numakura Kazuyuki, Habuchi Tomonori
Official Journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery ( Japan Association of Endocrine Surgeons・Japanese Society of Thyroid Surgery ) 39 ( 1 ) 44 - 48 2022
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Shuhei Takahashi, Shintaro Narita, Nobuhiro Fujiyama, Shingo Hatakeyama, Takashi Kobayashi, Renpei Kato, Sei Naito, Toru Sakatani, Soki Kashima, Atsushi Koizumi, Ryohei Yamamoto, Taketoshi Nara, Souhei Kanda, Kazuyuki Numakura, Mitsuru Saito, Wataru Obara, Norihiko Tsuchiya, Chikara Ohyama, Osamu Ogawa, Tomonori Habuchi
Cancer science 113 ( 12 ) 4059 - 4069 2022
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Ryuta Sobu, Kazuyuki Numakura, Sei Naito, Shingo Hatakeyama, Renpei Kato, Tomoyuki Koguchi, Takahiro Kojima, Yoshihide Kawasaki, Syuya Kandori, Sadafumi Kawamura, Yoichi Arai, Akihiro Ito, Hiroyuki Nishiyama, Yoshiyuki Kojima, Wataru Obara, Chikara Ohyama, Norihiko Tsuchiya, Tomonori Habuchi
Cancer medicine 12 ( 4 ) 4100 - 4109 2022
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SASAGAWA Hajime, NUMAKURA Kazuyuki, NAKAMURA Gaku, KUKIMOTO Takashi, KIKUCHI Akane, SAGEHASHI Ryuichiro, YAMAMOTO Ryohei, KOIZUMI Atsushi, NARA Taketoshi, KANDA Sohei, SAITO Mitsuru, NARITA Shintaro, INOUE Takamitsu, SATOH Shigeru, HABUCHI Tomonori
67 ( 12 ) 525 - 528 2021.12
A 46-year-old woman was referred to our hospital with a left-sided renal tumor pointed out by ultrasonography at the time of a medical checkup.Computed tomography revealed a mass measuring 88×77×68 mm on the upper pole of the left kidney. She was diagnosed with cT2aN0M0 clear cell renal cell carcinoma. Laparoscopic left nephrectomy was performed uneventfully. Histopathological diagnosis was clear cell renal cell carcinoma, G2, v1, pT2. Four months after surgery, lung metastases appeared, and systemic therapy was given sequentially as follows ; sunitinib for 2 months, nivolumab for 8 months, axitinib for 17 months, and pazopanib for 2 months.However, metastases progressed, and a re-administration of nivolumab was planned. The nivolumab re-treatment resulted in a marked reduction in multiple lung metastases despite the previous failure by nivolumab treatment. There are few reports on the therapeutic effect of re-administration of nivolumab. We report a case of successful treatment by re-administration of nivolumab.
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Molecular mechanisms and target molecules associated with progression and treatment resistance of urologic cancers associated with microbiome alterations by diet and obesity
Grant-in-Aid for Scientific Research(B)
Project Year： 2021.04 - 2025.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2020.04 - 2023.03
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Cancer stem cell characteristics in mTOR inhibitor-resistant kidney cancer cells
Grant-in-Aid for Scientific Research(C)
Project Year： 2017.04 - 2021.03 Investigator(s): Numakura Kazuyuki
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Molecular analysis and delineation of the mechanisms underlying progression of urogenital cancers and alteration of tumor immuno-microenvironment associated with adiposity enhancement
Grant-in-Aid for Scientific Research(A)
Project Year： 2016.04 - 2021.03 Investigator(s): Habuchi Tomonori